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Accurate instance-level segmentation of organelles in electron microscopy (EM) is critical for quantitative analysis of subcellular morphology and inter-organelle interactions. However, current benchmarks, based on small, curated datasets,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Yanrui Lu , Danyang Chen , Haowen Xiao , Jiarui Zhu , Fukang Ge , Binqian Zou , Jiali Guan , Jiayin Liang , Yuting Wang , Ziqian Guan , Xiangcheng Bao , Jinhao Bi , Lin Gu , Jun He , Yingying Zhu

We present Glioma C6, a new open dataset for instance segmentation of glioma C6 cells, designed as both a benchmark and a training resource for deep learning models. The dataset comprises 75 high-resolution phase-contrast microscopy images…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Roman Malashin , Svetlana Pashkevich , Daniil Ilyukhin , Arseniy Volkov , Valeria Yachnaya , Andrey Denisov , Maria Mikhalkova

Biological cells, by definition, are the basic units which contain the fundamental molecules of life of which all living things are composed. Understanding how they function and differentiating cells from one another therefore is of…

Signal Processing · Electrical Eng. & Systems 2021-01-07 Hassan Raji , Muhammad Tayyab , Jianye Sui , Seyed Reza Mahmoodi , Mehdi Javanmard

Semantic segmentation of medical images aims to associate a pixel with a label in a medical image without human initialization. The success of semantic segmentation algorithms is contingent on the availability of high-quality imaging data…

Semantic segmentation is the task of assigning a label to each pixel in the image.In recent years, deep convolutional neural networks have been driving advances in multiple tasks related to cognition. Although, DCNNs have resulted in…

Machine Learning · Computer Science 2017-12-12 Aditya Ganeshan

Two successful approaches for the segmentation of biomedical images are (1) the selection of segment candidates from a merge-tree, and (2) the clustering of small superpixels by solving a Multi-Cut problem. In this paper, we introduce a…

Computer Vision and Pattern Recognition · Computer Science 2017-07-05 Jan Funke , Chong Zhang , Tobias Pietzsch , Stephan Saalfeld

Accurate cell counting is essential in various biomedical research and clinical applications, including cancer diagnosis, stem cell research, and immunology. Manual counting is labor-intensive and error-prone, motivating automation through…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Abdurahman Ali Mohammed , Catherine Fonder , Ying Wei , Wallapak Tavanapong , Donald S Sakaguchi , Qi Li , Surya K. Mallapragada

In the last decade, research on artificial intelligence has seen rapid growth with deep learning models, especially in the field of medical image segmentation. Various studies demonstrated that these models have powerful prediction…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Dominik Müller , Iñaki Soto-Rey , Frank Kramer

In this paper, we propose a hybrid approach for multi-object microbial cell segmentation. The approach combines an ML-based detection with a geometry-aware variational-based segmentation using B-splines that are parametrized based on a…

Computer Vision and Pattern Recognition · Computer Science 2022-05-04 Karina Ruzaeva , Katharina Nöh , Benjamin Berkels

We propose a software platform that integrates methods and tools for multi-objective parameter auto- tuning in tissue image segmentation workflows. The goal of our work is to provide an approach for improving the accuracy of nucleus/cell…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-10-09 Luis F. R. Taveira , Tahsin Kurc , Alba C. M. A. Melo , Jun Kong , Erich Bremer , Joel H. Saltz , George Teodoro

Single cell segmentation is critical and challenging in live cell imaging data analysis. Traditional image processing methods and tools require time-consuming and labor-intensive efforts of manually fine-tuning parameters. Slight variations…

Quantitative Methods · Quantitative Biology 2019-04-24 Weikang Wang , David A. Taft , Yi-Jiun Chen , Jingyu Zhang , Callen T. Wallace , Min Xu , Simon C. Watkins , Jianhua Xing

Starting from a variational formulation, we present a model for image segmentation that employs both region statistics and edge information. This combination allows for improved flexibility, making the proposed model suitable to process a…

Analysis of PDEs · Mathematics 2019-10-15 Carlos M. Paniagua Mejia

Transfer learning is a critical technique in training deep neural networks for the challenging medical image segmentation task that requires enormous resources. With the abundance of medical image data, many research institutions release…

Computer Vision and Pattern Recognition · Computer Science 2023-07-25 Yuncheng Yang , Meng Wei , Junjun He , Jie Yang , Jin Ye , Yun Gu

Extracting single-cell information from microscopy data requires accurate instance-wise segmentations. Obtaining pixel-wise segmentations from microscopy imagery remains a challenging task, especially with the added complexity of…

Computer Vision and Pattern Recognition · Computer Science 2024-01-02 Christoph Reich , Tim Prangemeier , André O. Françani , Heinz Koeppl

Multi-modal medical image segmentation plays an essential role in clinical diagnosis. It remains challenging as the input modalities are often not well-aligned spatially. Existing learning-based methods mainly consider sharing trainable…

Computer Vision and Pattern Recognition · Computer Science 2021-01-06 Jingkun Chen , Wenqi Li , Hongwei Li , Jianguo Zhang

Pathological cell semantic segmentation is a fundamental technology in computational pathology, essential for applications like cancer diagnosis and effective treatment. Given that multiple cell types exist across various organs, with…

Computer Vision and Pattern Recognition · Computer Science 2024-12-05 Qing Zhang , Hang Guo , Siyuan Yang , Qingli Li , Yan Wang

Image segmentation, the process of partitioning an image into meaningful regions, plays a pivotal role in computer vision and medical imaging applications. Unsupervised segmentation, particularly in the absence of labeled data, remains a…

Computer Vision and Pattern Recognition · Computer Science 2024-05-13 Kovvuri Sai Gopal Reddy , Bodduluri Saran , A. Mudit Adityaja , Saurabh J. Shigwan , Nitin Kumar

This paper proposes a novel method for segmentation of images by hierarchical multilevel thresholding. The method is global, agglomerative in nature and disregards pixel locations. It involves the optimization of the ratio of the unbiased…

Computer Vision and Pattern Recognition · Computer Science 2007-12-27 Sreechakra Goparaju , Jayadev Acharya , Ajoy K. Ray , Jaideva C. Goswami

Medical image segmentation aims to identify anatomical structures at the voxel-level. Segmentation accuracy relies on distinguishing voxel differences. Compared to advancements achieved in studies of the inter-class variance, the…

Image and Video Processing · Electrical Eng. & Systems 2025-03-19 Yali Bi , Enyu Che , Yinan Chen , Yuanpeng He , Jingwei Qu

The rapid development of deep learning has made a great progress in image segmentation, one of the fundamental tasks of computer vision. However, the current segmentation algorithms mostly rely on the availability of pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2023-02-16 Wei Shen , Zelin Peng , Xuehui Wang , Huayu Wang , Jiazhong Cen , Dongsheng Jiang , Lingxi Xie , Xiaokang Yang , Qi Tian