Related papers: Motility induced phase separation of deformable ce…
Liquid-liquid phase separation is the mechanism underlying the formation of biomolecular condensates. Disordered protein regions often drive phase separation, but molecular interactions of disordered protein regions are not well understood,…
Biological mixtures such as the cytosol may consist of thousands of distinct components. There is now a substantial body of evidence showing that, under physiological conditions, intracellular mixtures can phase separate into spatially…
We present a comprehensive study of a model system of repulsive self-propelled disks in two dimensions with ferromagnetic and nematic velocity alignment interactions. We characterize the phase behavior of the system as a function of the…
The self-organization of proteins into enriched compartments and the formation of complex patterns are crucial processes for life on the cellular level. Liquid-liquid phase separation is one mechanism for forming such enriched compartments.…
The development of complex multicellular organisms from a single parent cell is a highly orchestrated process that cells conduct collectively without central guidance, creating intricate dynamic patterns essential for development and…
Self-propulsion in run-and-tumble particles (RTPs) generates effective attractive interactions that can drive motility-induced phase separation (MIPS), a phenomenon absent in passive systems. Here, we investigate RTPs in the presence of…
The morphogenesis of cells and tissues involves an interplay between chemical signals and active forces on their surrounding surface layers. The complex interaction of hydrodynamics and material flows on such active surfaces leads to…
We study motility-induced phase separation (MIPS) in symmetric and asymmetric active binary mixtures. We start with the coarse-grained run-and-tumble bacterial model that provides evolution equations for the density fields $\rho_i(\vec r,…
The effect of curvature on an ensemble of repulsive active Brownian particles (ABPs) moving on a spherical surface is studied. Surface curvature strongly affects the dynamics of ABPs, as it introduces a new time scale $\tau=R/v_0$, with…
Many types of mammalian cells exert active contractile forces and mechanically deform their elastic substrate, to accomplish biological functions such as cell migration. These substrate deformations provide a mechanism by which cells can…
Cell motility in dense cell collectives is pivotal in various diseases like cancer metastasis and asthma. A central aspect in these phenomena is the heterogeneity in cell motility, but identifying the motility of individual cells is…
The size and shape of a large variety of polymeric particles, including biological cells, star polymers, dendrimes, and microgels, depend on the applied stresses as the particles are extremely soft. In high-density suspensions these…
We study motility-induced phase separation~(MIPS) in active AB binary mixtures undergoing the chemical reaction $A \rightleftharpoons B$. Starting from the evolution equations for the density fields $\rho_i(\vec r, t)$ describing MIPS, we…
Multiphase field models have emerged as an important computational tool for understanding biological tissue while resolving single-cell properties. While they have successfully reproduced many experimentally observed behaviors of living…
One of the most intriguing phenomena in active matter has been the gas-liquid like motility induced phase separation (MIPS) observed in repulsive active particles. However, experimentally no particle can be a perfect sphere, and the…
Self-propelled particle (SPP) systems are intrinsically out of equilibrium systems, where each individual particle converts energy into work to move in a dissipative medium. When interacting through a velocity alignment mechanism, and the…
In this paper, phase field models are developed for multi-component vesicle membranes with different lipid compositions and membranes with free boundary. These models are used to simulate the deformation of membranes under the elastic…
In this article, we investigate the impact of self-alignment and anti-self-alignment on collective phenomena in dense active matter. These mechanisms correspond to effective torques that align or anti-align a particles orientation with its…
Understanding how microscopic motility shapes emergent collective behaviors is a challenging task in active matter, especially when self-propulsion is regulated by external cues or via quorum-sensing interactions. To address this problem,…
Phase separation of intrinsically disordered proteins is important for the formation of membraneless organelles, or biomolecular condensates, which play key roles in the regulation of biochemical processes within cells. In this work, we…