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We consider the problem of recovering the three-dimensional atomic structure of a flexible macromolecule from a heterogeneous cryo-EM dataset. The dataset contains noisy tomographic projections of the electrostatic potential of the…

Image and Video Processing · Electrical Eng. & Systems 2023-02-08 Carlos Esteve-Yagüe , Willem Diepeveen , Ozan Öktem , Carola-Bibiane Schönlieb

Cryo-electron microscopy (cryo-EM) enables single-particle analysis of biological macromolecules under strict low-dose imaging conditions, but the resulting micrographs often exhibit extremely low signal-to-noise ratios and weak particle…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Xiaoqi Wu , Xueying Zhan , Wen Li , Junhao Wu , Xin Huang , Min Xu

Cryo-electron microscopy (cryo-EM) has emerged as a powerful technique for resolving the three-dimensional structures of macromolecules. A key challenge in cryo-EM is characterizing continuous heterogeneity, where molecules adopt a…

Machine Learning · Statistics 2026-02-20 Roey Yadgar , Roy R. Lederman , Yoel Shkolnisky

As an increasing amount of image and video content will be analyzed by machines, there is demand for a new codec paradigm that is capable of compressing visual input primarily for the purpose of computer vision inference, while secondarily…

Image and Video Processing · Electrical Eng. & Systems 2023-01-12 Ezgi Ozyilkan , Mateen Ulhaq , Hyomin Choi , Fabien Racape

Supervised approaches to 3D pose estimation from single images are remarkably effective when labeled data is abundant. However, as the acquisition of ground-truth 3D labels is labor intensive and time consuming, recent attention has shifted…

Computer Vision and Pattern Recognition · Computer Science 2022-06-30 Soumava Kumar Roy , Leonardo Citraro , Sina Honari , Pascal Fua

3D scene reconstruction is a long-standing vision task. Existing approaches can be categorized into geometry-based and learning-based methods. The former leverages multi-view geometry but can face catastrophic failures due to the reliance…

Computer Vision and Pattern Recognition · Computer Science 2023-08-11 Guangkai Xu , Wei Yin , Hao Chen , Chunhua Shen , Kai Cheng , Feng Zhao

Cryo-electron tomography (cryo-ET) provides direct 3D visualization of macromolecules inside the cell, enabling analysis of their in situ morphology. This morphology can be regarded as an SE(3)-invariant, denoised volumetric representation…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Mostofa Rafid Uddin , Mahek Vora , Qifeng Wu , Muyuan Chen , Min Xu

Cryo-Electron Microscopy (cryo-EM) has emerged as a key technology to determine the structure of proteins, particularly large protein complexes and assemblies in recent years. A key challenge in cryo-EM data analysis is to automatically…

Biomolecules · Quantitative Biology 2023-04-04 Nabin Giri , Raj S. Roy , Jianlin Cheng

Current 6D object pose methods consist of deep CNN models fully optimized for a single object but with its architecture standardized among objects with different shapes. In contrast to previous works, we explicitly exploit each object's…

Computer Vision and Pattern Recognition · Computer Science 2020-09-04 Pedro Castro , Anil Armagan , Tae-Kyun Kim

The Cryo-EM 3D particle reconstruction is essential for identifying protein and uncover the biological mechanism of the macro-molecules. In this paper, we use Kam method for reconstruction. Kam method is \textit{ab-initio}, and it assumes…

Quantitative Methods · Quantitative Biology 2019-06-21 Yin Xian

Cryo-electron tomography (Cryo-ET) is a powerful tool in structural biology for 3D visualization of cells and biological systems at resolutions sufficient to identify individual proteins in situ. The measurements are collected by tilting…

Signal Processing · Electrical Eng. & Systems 2025-09-03 Vinith Kishore , Valentin Debarnot , AmirEhsan Khorashadizadeh , Ivan Dokmanić

3-D pose estimation of instruments is a crucial step towards automatic scene understanding in robotic minimally invasive surgery. Although robotic systems can potentially directly provide joint values, this information is not commonly…

Robotics · Computer Science 2021-03-02 Luca Sestini , Benoit Rosa , Elena De Momi , Giancarlo Ferrigno , Nicolas Padoy

Virtual beam diagnostics relies on computationally intensive beam dynamics simulations where high-dimensional charged particle beams evolve through the accelerator. We propose Latent Evolution Model (LEM), a hybrid machine learning…

Accelerator Physics · Physics 2026-02-27 Mahindra Rautela , Alexander Scheinker

In the past decade, deep conditional generative models have revolutionized the generation of realistic images, extending their application from entertainment to scientific domains. Single-particle cryo-electron microscopy (cryo-EM) is…

Computer Vision and Pattern Recognition · Computer Science 2024-10-01 Jiakai Zhang , Qihe Chen , Yan Zeng , Wenyuan Gao , Xuming He , Zhijie Liu , Jingyi Yu

Enhancing cryogenic electron microscopy (cryo-EM) 3D density maps at intermediate resolution (4-8 {\AA}) is crucial in protein structure determination. Recent advances in deep learning have led to the development of automated approaches for…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Chenwei Zhang , Khanh Dao Duc

RGB-based 3D pose estimation methods have been successful with the development of deep learning and the emergence of high-quality 3D pose datasets. However, most existing methods do not operate well for testing images whose distribution is…

Computer Vision and Pattern Recognition · Computer Science 2025-02-26 Hansoo Park , Chanwoo Kim , Jihyeon Kim , Hoseong Cho , Nhat Nguyen Bao Truong , Taehwan Kim , Seungryul Baek

Restoring images degraded by adverse weather remains a significant challenge due to the highly non-uniform and spatially heterogeneous nature of weather-induced artifacts, e.g., fine-grained rain streaks versus widespread haze. Accurately…

Computer Vision and Pattern Recognition · Computer Science 2025-10-24 Hainuo Wang , Qiming Hu , Xiaojie Guo

We introduce the first learning-based dense matching algorithm, termed Equirectangular Projection-Oriented Dense Kernelized Feature Matching (EDM), specifically designed for omnidirectional images. Equirectangular projection (ERP) images,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Dongki Jung , Jaehoon Choi , Yonghan Lee , Somi Jeong , Taejae Lee , Dinesh Manocha , Suyong Yeon

Reconstruction of 3D neural fields from posed images has emerged as a promising method for self-supervised representation learning. The key challenge preventing the deployment of these 3D scene learners on large-scale video data is their…

Computer Vision and Pattern Recognition · Computer Science 2023-06-02 Cameron Smith , Yilun Du , Ayush Tewari , Vincent Sitzmann

Structural flexibility and/or dynamic interactions with other molecules is a critical aspect of protein function. CryoEM provides direct visualization of individual macromolecules sampling different conformational and compositional states.…

Biomolecules · Quantitative Biology 2021-08-04 Muyuan Chen , Steven Ludtke