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In recent years, deep learning has made remarkable strides, surpassing human capabilities in tasks like strategy games, and it has found applications in complex domains, including protein folding. In the realm of quantum chemistry, machine…

Chemical Physics · Physics 2024-01-09 Rhyan Barrett , Julia Westermayr

Ising machines, hardware accelerators for combinatorial optimization and probabilistic sampling problems, have gained significant interest recently. A key element is stochasticity, which enables a wide exploration of configurations, thereby…

Disordered Systems and Neural Networks · Physics 2025-01-23 Kyle Lee , Shuvro Chowdhury , Kerem Y. Camsari

Recent developments in computational chemistry facilitate the automated quantum chemical exploration of chemical reaction networks for the in-silico prediction of synthesis pathways, yield, and selectivity. However, the underlying quantum…

Chemical Physics · Physics 2025-10-22 Marco Eckhoff , Markus Reiher

Many deep neural networks have been used to solve Ising models, including autoregressive neural networks, convolutional neural networks, recurrent neural networks, and graph neural networks. Learning a probability distribution of energy…

Statistical Mechanics · Physics 2024-11-20 Qunlong Ma , Zhi Ma , Jinlong Xu , Hairui Zhang , Ming Gao

Optimal MIMO detection has been one of the most challenging and computationally inefficient tasks in wireless systems. We show that the new analog computing techniques like Coherent Ising Machines (CIM) are promising candidates for…

Networking and Internet Architecture · Computer Science 2024-09-06 Abhishek Kumar Singh , Kyle Jamieson , Davide Venturelli , Peter McMahon

When tackling binary optimization problems using quantum algorithms, the conventional Ising representation and Quantum Approximate Optimization Algorithm (QAOA) encounter difficulties in efficiently handling errors for large-scale problems…

Quantum Physics · Physics 2023-05-16 Ke Wan , Yiwen Liu

The accurate computational determination of chemical, materials, biological, and atmospheric properties has critical impact on a wide range of health and environmental problems, but is deeply limited by the computational scaling of…

Chemical Physics · Physics 2021-06-09 Debadrita Saha , Srinivasan S. Iyengar , Philip Richerme , Jeremy M. Smith , Amr Sabry

Quantum computing (QC) provides a promising avenue toward enabling quantum chemistry calculations, which are classically impossible due to a computational complexity that increases exponentially with system size. As fully fault-tolerant…

In combinatorial optimization, probabilistic Ising machines (PIMs) have gained significant attention for their acceleration of Monte Carlo sampling with the potential to reduce time-to-solution in finding approximate ground states. However,…

Materials Science · Physics 2025-06-18 Shuhan Yang , Andrea Grimaldi , Youwei Bao , Eleonora Raimondo , Jia Si , Giovanni Finocchio , Hyunsoo Yang

Simulating chemical systems is highly sought after and computationally challenging, as the number of degrees of freedom increases exponentially with the size of the system. Quantum computers have been proposed as a computational means to…

Optimization algorithms play a central role in chemistry since optimization is the computational keystone of most molecular and electronic structure calculations. Herein, we introduce the iterative power algorithm (IPA) for global…

Quantum Physics · Physics 2021-05-19 Micheline B. Soley , Paul Bergold , Victor S. Batista

Variational methods offer a highly promising route to exploiting quantum computers for chemistry tasks. Here we employ methods described in a sister paper to the present report, entitled ab initio machine synthesis of quantum circuits, in…

Quantum Physics · Physics 2023-08-09 Cica Gustiani , Richard Meister , Simon C. Benjamin

For the investigation of chemical reaction networks, the identification of all relevant intermediates and elementary reactions is mandatory. Many algorithmic approaches exist that perform explorations efficiently and automatedly. These…

Chemical Physics · Physics 2019-05-24 Gregor N. Simm , Alain C. Vaucher , Markus Reiher

Transition states and minimum energy paths are essential to understand and predict chemical reactivity. Double-ended methods represent a standard approach for their determination. We introduce a new double-ended method that optimizes…

Chemical Physics · Physics 2020-02-18 Alain C. Vaucher , Markus Reiher

Quantum computing has emerged as a powerful tool to efficiently solve computational challenges, particularly in simulation and optimisation. However, hardware limitations prevent quantum computers from achieving the full theoretical…

Emerging Technologies · Computer Science 2025-05-01 Hugo Araujo , Xinyi Wang , Mohammad Mousavi , Shaukat Ali

Given the fundamental importance of combinatorial optimization across many diverse application domains, there has been widespread interest in the development of unconventional physical computing architectures that can deliver better…

Disordered Systems and Neural Networks · Physics 2023-09-18 Atsushi Yamamura , Hideo Mabuchi , Surya Ganguli

This study systematically benchmarks several non-fault-tolerant quantum computing algorithms across four distinct optimization problems: max-cut, number partitioning, knapsack, and quantum spin glass. Our benchmark includes noisy…

Quantum Physics · Physics 2024-10-31 Santaro Kikuura , Ryoya Igata , Yuta Shingu , Shohei Watabe

Current quantum annealing (QA) hardware suffers from practical limitations such as finite temperature, sparse connectivity, small qubit numbers, and control error. We propose new algorithms for mapping boolean constraint satisfaction…

Quantum Physics · Physics 2016-03-11 Zhengbing Bian , Fabian Chudak , Robert Israel , Brad Lackey , William G. Macready , Aidan Roy

Airfoil shape optimization presents a challenge where classical solvers frequently struggle with computational efficiency and local minima. In the promising paradigm of quantum computing, the coherent Ising machine (CIM), a specialized…

Quantum Physics · Physics 2026-03-12 Hao Ni , Qi Gao , Zhen Lu , Yue Yang

In the framework of risk assessment in nuclear accident analysis, best-estimatecomputer codes, associated to a probabilistic modeling of the uncertain input variables,are used to estimate safety margins. A first step in such uncertainty…

Computational Engineering, Finance, and Science · Computer Science 2021-08-30 A. Marrel , Bertrand Iooss , V Chabridon