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Purpose: Diffusion MRI (dMRI) provides a diverse set of quantitative measures and derived datatypes to assess white matter microstructure and macrostructure. Coupled with the increasing size of imaging studies using dMRI, the number of…

We demonstrate a novel imaging approach and associated reconstruction algorithm for far-field coherent diffractive imaging, based on the measurement of a pair of laterally sheared diffraction patterns. The differential phase profile…

Optics · Physics 2018-05-23 G. S. M. Jansen , A. C. C. de Beurs , X. Liu , K. S. E. Eikema , S. Witte

Nonlinear computation is essential for various information processing tasks. Optical implementations are attractive because passive light propagation can manipulate high-dimensional signals with extreme throughput and parallelism; yet…

We report a monochrome multi-task diffractive network architecture that leverages illumination phase multiplexing to dynamically reconfigure its output function and accurately implement a large group of complex-valued linear transformations…

Optics · Physics 2025-12-09 Xiao Wang , Aydogan Ozcan

Oversmoothing remains a persistent problem when applying deep learning to off-axis quantitative phase imaging (QPI). End-to-end U-Nets favour low-frequency content and under-represent fine, diagnostic detail. We trace this issue to spectral…

Image and Video Processing · Electrical Eng. & Systems 2025-06-16 Yi Zhang

Conventional spectrometer and polarimeter systems rely on bulky optics, fundamentally limiting compact integration and hindering multi-dimensional optical sensing capabilities. Here, we propose a spectropolarimeter enabled by…

Optics · Physics 2026-04-13 Jumin Qiu , Tingting Liu , Chenxuan Xiang , Tianbao Yu , Qiegen Liu , Shuyuan Xiao

Protocols for processing of quantum information are the foundation of quantum technology, enabling to share secrets at a distance, teleport quantum states, and to implement quantum computation. While many protocols were realized, and even…

Quantum Physics · Physics 2024-11-21 Alon Eldan , Ofek Gilon , Asher Lagemi , Elai Fishman Furman , Avi Pe'er

We report the design of diffractive surfaces to all-optically perform arbitrary complex-valued linear transformations between an input (N_i) and output (N_o), where N_i and N_o represent the number of pixels at the input and output…

Optics · Physics 2021-09-27 Onur Kulce , Deniz Mengu , Yair Rivenson , Aydogan Ozcan

We report deep learning-based design of a massively parallel broadband diffractive neural network for all-optically performing a large group of arbitrarily-selected, complex-valued linear transformations between an input and output…

Neural and Evolutionary Computing · Computer Science 2023-01-10 Jingxi Li , Bijie Bai , Yi Luo , Aydogan Ozcan

Interferometry techniques are essential for extracting phase information from optical systems, enabling precise measurements of dispersion and highly sensitive detection of perturbations. While phase sensing offers enhanced sensitivity…

Quantum information offers the promise of being able to perform certain communication and computation tasks that cannot be done with conventional information technology (IT). Optical Quantum Information Processing (QIP) holds particular…

Quantum Physics · Physics 2009-11-11 W. J. Munro , Kae Nemoto , T. P. Spiller , S. D. Barrett , Pieter Kok , R. G. Beausoleil

Large field-of-view (FOV) microscopic imaging with high lateral resolution (1-2 microns for high space-bandwidth product) plays a pivotal role in biomedicine and biophotonics, especially within the label-free regime, e.g., for whole slide…

Measuring the phase of light is fundamental to optical imaging, sensing, and signal processing applications. Conventional optical phase measurements rely on multipath configurations, bulky interferometric setups, and computationally…

Vibrational micro-spectroscopy is a powerful optical tool, providing a non-invasive label-free chemically specific imaging for many chemical and biomedical applications. However, hyperspectral image produced by Raman micro-spectroscopy…

Computational Physics · Physics 2019-03-12 E. G. Lobanova , S. V. Lobanov

Quantum entanglement and squeezing have significantly improved phase estimation and imaging in interferometric settings beyond the classical limits. However, for a wide class of non-interferometric phase imaging/retrieval methods vastly…

Quantum imaging with undetected photons (QIUP) is an emerging technique that decouples the processes of illuminating an object and projecting its image. The properties of the illuminating and detected light can thus be simultaneously…

Quantitative phase microscopy (QPM) enables label-free measurement of local optical path length variations, providing critical insight into the structure and dynamics of transparent biological specimens. Here, a highly sensitive lateral…

Interferometric imaging is a well established method to image phase objects by mixing the image wavefront with a reference one on a CCD camera. It has also been applied to fast transient phenomena, mostly through the analysis of single…

We have proposed and developed a method to utilize attosecond pulses in diffraction imaging techniques applied to complex samples. In this study, the effects of the broadband properties of the wavefield owing to attosecond pulses are…

Optics · Physics 2023-12-01 G. N. Tran , Katsumi Midorikawa , Eiji J. Takahashi

Recovering both amplitude and phase information from a system is a fundamental goal of optical imaging. At the same time, it is crucial to operate at low photon doses to avoid altering the sample, particularly in biological applications.…

Quantum Physics · Physics 2026-01-15 Alberto Paniate , Giuseppe Ortolano , Sarika Soman , Marco Genovese , Ivano Ruo-Berchera