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Pre-trained large language models(LLMs) have attracted increasing attention in biomedical domains due to their success in natural language processing. However, the complex traits and heterogeneity of multi-sources genomics data pose…

Computation and Language · Computer Science 2025-11-25 Yanjun Lyu , Zihao Wu , Lu Zhang , Jing Zhang , Yiwei Li , Wei Ruan , Zhengliang Liu , Zeyu Zhang , Xiang Li , Rongjie Liu , Chao Huang , Wentao Li , Tianming Liu , Dajiang Zhu

Pre-training on larger datasets with ever increasing model size is now a proven recipe for increased performance across almost all NLP tasks. A notable exception is information retrieval, where additional pre-training has so far failed to…

Graph neural networks (GNNs) are shown to be successful in modeling applications with graph structures. However, training an accurate GNN model requires a large collection of labeled data and expressive features, which might be inaccessible…

Machine Learning · Computer Science 2019-06-03 Ziniu Hu , Changjun Fan , Ting Chen , Kai-Wei Chang , Yizhou Sun

Modeling genomic sequences faces two unsolved challenges: the information density varies widely across different regions, while there is no clearly defined minimum vocabulary unit. Relying on either four primitive bases or independently…

Genomics · Quantitative Biology 2025-11-20 Siyuan Li , Kai Yu , Anna Wang , Zicheng Liu , Chang Yu , Jingbo Zhou , Qirong Yang , Yucheng Guo , Xiaoming Zhang , Stan Z. Li

We propose pre-finetuning, an additional large-scale learning stage between language model pre-training and fine-tuning. Pre-finetuning is massively multi-task learning (around 50 datasets, over 4.8 million total labeled examples), and is…

Computation and Language · Computer Science 2021-01-28 Armen Aghajanyan , Anchit Gupta , Akshat Shrivastava , Xilun Chen , Luke Zettlemoyer , Sonal Gupta

Learning time-series representations for discriminative tasks, such as classification and regression, has been a long-standing challenge in the healthcare domain. Current pre-training methods are limited in either unidirectional next-token…

Artificial Intelligence · Computer Science 2024-08-27 Ziyang Song , Qincheng Lu , He Zhu , David Buckeridge , Yue Li

Foundation models are large-scale machine learning models that are pre-trained on massive amounts of data and can be adapted for various downstream tasks. They have been extensively applied to tasks in Natural Language Processing and…

In the global challenge of understanding and characterizing biodiversity, short species-specific genomic sequences known as DNA barcodes play a critical role, enabling fine-grained comparisons among organisms within the same kingdom of…

The rapid advancement of Large Language Models (LLMs) has revolutionized various sectors by automating routine tasks, marking a step toward the realization of Artificial General Intelligence (AGI). However, they still struggle to…

Machine Learning · Computer Science 2024-02-21 Zihao Tang , Zheqi Lv , Shengyu Zhang , Fei Wu , Kun Kuang

In this work, we investigate multi-task learning as a way of pre-training models for classification tasks in digital pathology. It is motivated by the fact that many small and medium-size datasets have been released by the community over…

Image and Video Processing · Electrical Eng. & Systems 2020-05-19 Romain Mormont , Pierre Geurts , Raphaël Marée

Heterogeneous graph learning aims to capture complex relationships and diverse relational semantics among entities in a heterogeneous graph to obtain meaningful representations for nodes and edges. Recent advancements in heterogeneous graph…

Computation and Language · Computer Science 2024-05-21 Jiabin Tang , Yuhao Yang , Wei Wei , Lei Shi , Long Xia , Dawei Yin , Chao Huang

This paper introduces ClimateGPT, a model family of domain-specific large language models that synthesize interdisciplinary research on climate change. We trained two 7B models from scratch on a science-oriented dataset of 300B tokens. For…

In the backdrop of increasing data requirements of Deep Neural Networks for object recognition that is growing more untenable by the day, we present Developmental PreTraining (DPT) as a possible solution. DPT is designed as a…

Machine Learning · Computer Science 2023-12-04 Niranjan Rajesh , Debayan Gupta

With the urgent demand for generalized deep models, many pre-trained big models are proposed, such as BERT, ViT, GPT, etc. Inspired by the success of these models in single domains (like computer vision and natural language processing), the…

Computer Vision and Pattern Recognition · Computer Science 2024-04-11 Xiao Wang , Guangyao Chen , Guangwu Qian , Pengcheng Gao , Xiao-Yong Wei , Yaowei Wang , Yonghong Tian , Wen Gao

Recently, graph neural networks (GNNs) have been shown powerful capacity at modeling structural data. However, when adapted to downstream tasks, it usually requires abundant task-specific labeled data, which can be extremely scarce in…

Machine Learning · Computer Science 2022-03-04 Yupeng Hou , Binbin Hu , Wayne Xin Zhao , Zhiqiang Zhang , Jun Zhou , Ji-Rong Wen

Graph pre-training strategies have been attracting a surge of attention in the graph mining community, due to their flexibility in parameterizing graph neural networks (GNNs) without any label information. The key idea lies in encoding…

Machine Learning · Computer Science 2022-08-23 Dawei Zhou , Lecheng Zheng , Dongqi Fu , Jiawei Han , Jingrui He

ChatGPT is one of the most popular language models which achieve amazing performance on various natural language tasks. Consequently, there is also an urgent need to detect the texts generated ChatGPT from human written. One of the…

Computation and Language · Computer Science 2023-10-04 Han Xu , Jie Ren , Pengfei He , Shenglai Zeng , Yingqian Cui , Amy Liu , Hui Liu , Jiliang Tang

Generative, pre-trained transformers (GPTs, a.k.a. "Foundation Models") have reshaped natural language processing (NLP) through their versatility in diverse downstream tasks. However, their potential extends far beyond NLP. This paper…

Machine Learning · Computer Science 2023-06-22 Matthew B. A. McDermott , Bret Nestor , Peniel Argaw , Isaac Kohane

Foundational models, pretrained on a large scale, have demonstrated substantial success across non-medical domains. However, training these models typically requires large, comprehensive datasets, which contrasts with the smaller and more…

Computer Vision and Pattern Recognition · Computer Science 2023-11-17 Raphael Schäfer , Till Nicke , Henning Höfener , Annkristin Lange , Dorit Merhof , Friedrich Feuerhake , Volkmar Schulz , Johannes Lotz , Fabian Kiessling

The upsurge in pre-trained large models started by ChatGPT has swept across the entire deep learning community. Such powerful models demonstrate advanced generative ability and multimodal understanding capability, which quickly set new…

Computer Vision and Pattern Recognition · Computer Science 2025-02-28 Ning Ding , Yehui Tang , Zhongqian Fu , Chao Xu , Kai Han , Yunhe Wang