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To improve the reliability of Large Language Models (LLMs) in clinical applications, retrieval-augmented generation (RAG) is extensively applied to provide factual medical knowledge. However, beyond general medical knowledge from open-ended…

Computation and Language · Computer Science 2025-05-29 Justice Ou , Tinglin Huang , Yilun Zhao , Ziyang Yu , Peiqing Lu , Rex Ying

Clinical trial records are variable resources or the analysis of patients and diseases. Information extraction from free text such as eligibility criteria and summary of results and conclusions in clinical trials would better support…

Computation and Language · Computer Science 2020-01-01 Yingcheng Sun , Kenneth Loparo

The past decade has seen an explosion in the amount of digital information stored in electronic health records (EHR). While primarily designed for archiving patient clinical information and administrative healthcare tasks, many researchers…

Machine Learning · Computer Science 2018-02-27 Benjamin Shickel , Patrick Tighe , Azra Bihorac , Parisa Rashidi

The large volume of text in electronic healthcare records often remains underused due to a lack of methodologies to extract interpretable content. Here we present an unsupervised framework for the analysis of free text that combines…

Motivation: Electronic health record (EHR) data provides a new venue to elucidate disease comorbidities and latent phenotypes for precision medicine. To fully exploit its potential, a realistic data generative process of the EHR data needs…

Machine Learning · Computer Science 2021-05-05 Ziyang Song , Xavier Sumba Toral , Yixin Xu , Aihua Liu , Liming Guo , Guido Powell , Aman Verma , David Buckeridge , Ariane Marelli , Yue Li

The paper presents a systematic review of state-of-the-art approaches to identify patient cohorts using electronic health records. It gives a comprehensive overview of the most commonly de-tected phenotypes and its underlying data sets.…

Machine Learning · Statistics 2017-07-25 Norman Hiob , Stefan Lessmann

The healthcare environment is commonly referred to as "information-rich" but also "knowledge poor". Healthcare systems collect huge amounts of data from various sources: lab reports, medical letters, logs of medical tools or programs,…

Computation and Language · Computer Science 2024-01-22 Elena-Simona Apostol , Ciprian-Octavian Truică

Objective: Social determinants of health (SDOH) impact health outcomes and are documented in the electronic health record (EHR) through structured data and unstructured clinical notes. However, clinical notes often contain more…

Computation and Language · Computer Science 2023-04-17 Kevin Lybarger , Nicholas J Dobbins , Ritche Long , Angad Singh , Patrick Wedgeworth , Ozlem Ozuner , Meliha Yetisgen

We present a new text-to-SQL dataset for electronic health records (EHRs). The utterances were collected from 222 hospital staff members, including physicians, nurses, and insurance review and health records teams. To construct the QA…

Computation and Language · Computer Science 2026-03-06 Gyubok Lee , Hyeonji Hwang , Seongsu Bae , Yeonsu Kwon , Woncheol Shin , Seongjun Yang , Minjoon Seo , Jong-Yeup Kim , Edward Choi

Causal inference is the process of estimating the effect or impact of a treatment on an outcome with other covariates as potential confounders (and mediators) that may need to be controlled. The vast majority of existing methods and systems…

Computation and Language · Computer Science 2022-05-05 Arun S. Maiya

Conventional machine learning models, particularly tree-based approaches, have demonstrated promising performance across various clinical prediction tasks using electronic health record (EHR) data. Despite their strengths, these models…

Computation and Language · Computer Science 2025-05-26 Sara Ketabi , Dhanesh Ramachandram

Electronic Health Records (EHRs) are typically stored as time-stamped encounter records. Observing temporal relationship between medical records is an integral part of interpreting the information. Hence, statistical analysis of EHRs…

Applications · Statistics 2020-07-29 Anne Woods , Craig Meyer , Brian Sauer , Beth Cohen

While randomized controlled trials (RCTs) are the gold-standard for establishing the efficacy and safety of a medical treatment, real-world evidence (RWE) generated from real-world data (RWD) has been vital in post-approval monitoring and…

Electronic Health Records (EHRs) provide vital contextual information to radiologists and other physicians when making a diagnosis. Unfortunately, because a given patient's record may contain hundreds of notes and reports, identifying…

Machine learning-based multi-label medical text classifications can be used to enhance the understanding of the human body and aid the need for patient care. We present a broad study on clinical natural language processing techniques to…

Information Retrieval · Computer Science 2020-04-02 Vithya Yogarajan , Jacob Montiel , Tony Smith , Bernhard Pfahringer

In this paper, we introduce EHR-SeqSQL, a novel sequential text-to-SQL dataset for Electronic Health Record (EHR) databases. EHR-SeqSQL is designed to address critical yet underexplored aspects in text-to-SQL parsing: interactivity,…

Computation and Language · Computer Science 2024-07-31 Jaehee Ryu , Seonhee Cho , Gyubok Lee , Edward Choi

Machine learning provides many powerful and effective techniques for analysing heterogeneous electronic health records (EHR). Administrative Health Records (AHR) are a subset of EHR collected for administrative purposes, and the use of…

Machine Learning · Computer Science 2023-08-29 Adrian Caruana , Madhushi Bandara , Katarzyna Musial , Daniel Catchpoole , Paul J. Kennedy

Electronic Health Records have become popular sources of data for secondary research, but their use is hampered by the amount of effort it takes to overcome the sparsity, irregularity, and noise that they contain. Modern learning…

Applications · Statistics 2025-02-28 Jacek M. Bajor , Diego A. Mesa , Travis J. Osterman , Thomas A. Lasko

Machine learning holds great promise for advancing the field of medicine, with electronic health records (EHRs) serving as a primary data source. However, EHRs are often sparse and contain missing data due to various challenges and…

Machine Learning · Computer Science 2026-02-25 Jun Han , Josue Nassar , Sanjit Singh Batra , Aldo Cordova-Palomera , Vijay Nori , Robert E. Tillman

There is increasing interest in combining information from experimental studies, including randomized and single-group trials, with information from external experimental or observational data sources. Such efforts are usually motivated by…

Methodology · Statistics 2026-04-23 Lawson Ung , Guanbo Wang , Sebastien Haneuse , Miguel A. Hernán , Issa J. Dahabreh
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