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Discriminative analysis in neuroimaging by means of deep/machine learning techniques is usually tested with validation techniques, whereas the associated statistical significance remains largely under-developed due to their computational…

In this paper, we described a set of computational technologies for image analysis with applications in Brain Morphometry. The proposed technologies are based on a new Variational Principle which constructs a transformation with prescribed…

Computational Geometry · Computer Science 2018-10-31 Zicong Zhou , Ben Hildebrandt , Xi Chen , Guojun Liao

This paper studies analytic inference along two dimensions of clustering. In such setups, the commonly used approach has two drawbacks. First, the corresponding variance estimator is not necessarily positive. Second, inference is invalid in…

Econometrics · Economics 2026-02-20 Laurent Davezies , Xavier D'Haultfœuille , Yannick Guyonvarch

In settings where most deaths occur outside the healthcare system, verbal autopsies (VAs) are a common tool to monitor trends in causes of death (COD). VAs are interviews with a surviving caregiver or relative that are used to predict the…

Computation and Language · Computer Science 2024-04-04 Shuxian Fan , Adam Visokay , Kentaro Hoffman , Stephen Salerno , Li Liu , Jeffrey T. Leek , Tyler H. McCormick

Variational inference (VI) has become the method of choice for fitting many modern probabilistic models. However, practitioners are faced with a fragmented literature that offers a bewildering array of algorithmic options. First, the…

Machine Learning · Statistics 2018-11-29 Thang D. Bui , Cuong V. Nguyen , Siddharth Swaroop , Richard E. Turner

Explaining the decision process of machine learning algorithms is nowadays crucial for both model's performance enhancement and human comprehension. This can be achieved by assessing the variable importance of single variables, even for…

Machine Learning · Computer Science 2023-12-19 Ahmad Chamma , Bertrand Thirion , Denis A. Engemann

NORI performs probabilistic inference to resolve ambiguous mappings between experimental observations and biological entities orders of magnitude faster than state-of-the-art methods. This makes large-scale analysis and extensive…

Quantitative Methods · Quantitative Biology 2026-05-13 Simon Van de Vyver , Tibo Vande Moortele , Ben-Björn Binke , Pieter Verschaffelt , Peter Dawyndt , Bart Mesuere

Recently, Eklund et al. (2016) analyzed clustering methods in standard FMRI packages: AFNI (which we maintain), FSL, and SPM [1]. They claimed: 1) false positive rates (FPRs) in traditional approaches are greatly inflated, questioning the…

Quantitative Methods · Quantitative Biology 2022-06-08 Robert W. Cox , Gang Chen , Daniel R. Glen , Richard C. Reynolds , Paul A. Taylor

This paper introduces a novel nonparametric criterion for determining the appropriate number of clusters, which is derived from the spatial median. The method is constructed to reconcile two competing objectives of cluster analysis: the…

Computation · Statistics 2025-09-26 Hend Gabr , Brian H Willis , Mohammed Baragilly

In voxel-based neuroimage analysis, lesion features have been the main focus in disease prediction due to their interpretability with respect to the related diseases. However, we observe that there exists another type of features introduced…

Applications · Statistics 2017-06-13 Xinwei Sun , Lingjing Hu , Yuan Yao , Yizhou Wang

An improved image mining technique for brain tumor classification using pruned association rule with MARI algorithm is presented in this paper. The method proposed makes use of association rule mining technique to classify the CT scan brain…

Computer Vision and Pattern Recognition · Computer Science 2010-01-13 P. Rajendran , M. Madheswaran

One approach, for understanding human brain functioning, is to analyze the changes in the brain while performing cognitive tasks. Towards this, Functional Magnetic Resonance (fMR) images of subjects performing well-defined tasks are widely…

Computer Vision and Pattern Recognition · Computer Science 2016-04-20 Hariharan Ramasangu , Neelam Sinha

A conventional Bayesian approach to prediction uses the posterior distribution to integrate out parameters in a density for unobserved data conditional on the observed data and parameters. When the true posterior is intractable, it is…

Methodology · Statistics 2026-02-27 Lucas Kock , Scott A. Sisson , G. S. Rodrigues , David J. Nott

This paper presents an adaptive resonance theory predictive mapping (ARTMAP) model which uses incremental cluster validity indices (iCVIs) to perform unsupervised learning, namely iCVI-ARTMAP. Incorporating iCVIs to the decision-making and…

Machine Learning · Computer Science 2020-08-25 Leonardo Enzo Brito da Silva , Nagasharath Rayapati , Donald C. Wunsch

We are glad that our paper has generated intense discussions in the fMRI field, on how to analyze fMRI data and how to correct for multiple comparisons. The goal of the paper was not to disparage any specific fMRI software, but to point out…

Applications · Statistics 2017-05-31 Anders Eklund , Thomas Nichols , Hans Knutsson

This paper proposes a nonparametric Bayesian framework called VariScan for simultaneous clustering, variable selection, and prediction in high-throughput regression settings. Poisson-Dirichlet processes are utilized to detect…

Methodology · Statistics 2019-10-08 Subharup Guha , Veerabhadran Baladandayuthapani

The Adjusted Rand Index (ARI) is a widely used method for comparing hard clusterings, but requires a choice of random model that is often left implicit. Several recent works have extended the Rand Index to fuzzy clusterings, but the…

Machine Learning · Statistics 2025-02-17 Ryan DeWolfe , Jeffery L. Andrews

Multi-subject functional magnetic resonance imaging (fMRI) data has been increasingly used to study the population-wide relationship between human brain activity and individual biological or behavioral traits. A common method is to regress…

Applications · Statistics 2015-09-15 Fan Li , Tingting Zhang , Quanli Wang , Marlen Z. Gonzalez , Erin L. Maresh , James A. Coan

Replicability is a cornerstone of science. The partial conjunction (PC) hypothesis testing framework objectively quantifies replicability across disciplines. Although several statistical methodologies for testing PC hypotheses exist, it is…

Methodology · Statistics 2026-03-18 Monitirtha Dey , Anna Vesely , Thorsten Dickhaus

This article proposes a novel variance estimator for within-cluster resampling (WCR) and modified within-cluster resampling (MWCR) - two existing methods for analyzing longitudinal data. WCR is a simple but computationally intensive method,…

Methodology · Statistics 2019-12-02 Daniel Xu , Pamela Shaw , Ian Barnett