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All Resolutions Inference (ARI) is a post hoc inference method for functional Magnetic Resonance Imaging (fMRI) data analysis that provides valid lower bounds on the proportion of truly active voxels within any, possibly data-driven,…

Statistics Theory · Mathematics 2025-11-05 Nils Peyrouset , Pierre Neuvial , Bertrand Thirion

Cluster-level inference procedures are widely used for brain mapping. These methods compare the size of clusters obtained by thresholding brain maps to an upper bound under the global null hypothesis, computed using Random Field Theory or…

Methodology · Statistics 2022-07-27 Alexandre Blain , Bertrand Thirion , Pierre Neuvial

The most widely used task fMRI analyses use parametric methods that depend on a variety of assumptions. While individual aspects of these fMRI models have been evaluated, they have not been evaluated in a comprehensive manner with empirical…

Applications · Statistics 2016-07-14 Anders Eklund , Thomas Nichols , Hans Knutsson

Decision making can be a complex process requiring the integration of several attributes of choice options. Understanding the neural processes underlying (uncertain) investment decisions is an important topic in neuroeconomics. We analyzed…

Applications · Statistics 2025-01-08 Piotr Majer , Peter N. C. Mohr , Hauke R. Heekeren , Wolfgang K. Härdle

Functional magnetic resonance imaging (fMRI) produces data about activity inside the brain, from which spatial maps can be extracted by independent component analysis (ICA). In datasets, there are n spatial maps that contain p voxels. The…

Computational Engineering, Finance, and Science · Computer Science 2016-11-17 Tuomo Sipola , Fengyu Cong , Tapani Ristaniemi , Vinoo Alluri , Petri Toiviainen , Elvira Brattico , Asoke K. Nandi

In computational neuroscience, it is important to estimate well the proportion of signal variance in the total variance of neural activity measurements. This explainable variance measure helps neuroscientists assess the adequacy of…

Applications · Statistics 2014-01-14 Yuval Benjamini , Bin Yu

We propose a method that combines signals from many brain regions observed in functional Magnetic Resonance Imaging (fMRI) to predict the subject's behavior during a scanning session. Such predictions suffer from the huge number of brain…

Computer Vision and Pattern Recognition · Computer Science 2011-04-29 Vincent Michel , Alexandre Gramfort , Gaël Varoquaux , Evelyn Eger , Christine Keribin , Bertrand Thirion

This thesis is dedicated to the statistical analysis of multi-sub ject fMRI data, with the purpose of identifying bain structures involved in certain cognitive or sensori-motor tasks, in a reproducible way across sub jects. To overcome…

Applications · Statistics 2010-05-19 Merlin Keller , Alexis Roche , Marc Lavielle

Voxel-based lesion-symptom mapping (VLSM) is an important method for basic and translational human neuroscience research. VLSM leverages modern neuroimaging analysis techniques to build on the classic approach of examining the relationship…

Recent reports of inflated false positive rates (FPRs) in FMRI group analysis tools by Eklund et al. (2016) have become a large topic within (and outside) neuroimaging. They concluded that: existing parametric methods for determining…

Quantitative Methods · Quantitative Biology 2017-02-17 Robert W. Cox , Gang Chen , Daniel R. Glen , Richard C. Reynolds , Paul A. Taylor

Functional connectivity (FC) derived from functional magnetic resonance imaging (fMRI) data offers vital insights for understanding brain function and neurological and psychiatric disorders. Unsupervised clustering methods are desired to…

Methodology · Statistics 2025-12-04 Yixi Xu , Yi Zhao

Classical cluster inference is hampered by the spatial specificity paradox. Given the null-hypothesis of no active voxels, the alternative hypothesis states that there is at least one active voxel in a cluster. Hence, the larger the cluster…

Methodology · Statistics 2023-05-12 Xu Chen , Jelle J. Goeman , Thijmen J. P. Krebs , Rosa J. Meijer , Wouter D. Weeda

We consider the simultaneous clustering of rows and columns of a matrix and more particularly the ability to measure the agreement between two co-clustering partitions. The new criterion we developed is based on the Adjusted Rand Index and…

Applications · Statistics 2020-12-16 Valerie Robert , Yann Vasseur , Vincent Brault

Variable importance assessment has become a crucial step in machine-learning applications when using complex learners, such as deep neural networks, on large-scale data. Removal-based importance assessment is currently the reference…

Machine Learning · Computer Science 2023-10-27 Ahmad Chamma , Denis A. Engemann , Bertrand Thirion

Functional magnetic resonance imaging (fMRI) aims to locate activated regions in human brains when specific tasks are performed. The conventional tool for analyzing fMRI data applies some variant of the linear model, which is restrictive in…

Statistics Theory · Mathematics 2008-08-08 Chunming Zhang , Tao Yu

Evaluating clustering quality with reliable evaluation metrics like normalized mutual information (NMI) requires labeled data that can be expensive to annotate. We focus on the underexplored problem of estimating clustering quality with…

Machine Learning · Computer Science 2022-10-04 Nihal V. Nayak , Ethan R. Elenberg , Clemens Rosenbaum

Statistical inference on functional magnetic resonance imaging (fMRI) data is an important task in brain imaging. One major hypothesis is that the presence or not of a psychiatric disorder can be explained by the differential clustering of…

Methodology · Statistics 2013-11-27 André Fujita , Daniel Y. Takahashi , Alexandre G. Patriota , João R. Sato

Cluster inference based on spatial extent thresholding is the most popular analysis method for finding activated brain areas in neuroimaging. However, the method has several well-known issues. While powerful for finding brain regions with…

Methodology · Statistics 2022-08-10 Jelle J. Goeman , Paweł\ Górecki , Ramin Monajemi , Xu Chen , Thomas E. Nichols , Wouter Weeda

We propose a permutation-based method for testing a large collection of hypotheses simultaneously. Our method provides lower bounds for the number of true discoveries in any selected subset of hypotheses. These bounds are simultaneously…

Applications · Statistics 2023-01-30 Angela Andreella , Jesse Hemerik , Wouter Weeda , Livio Finos , Jelle Goeman

In the partially-observed outcome setting, a recent set of proposals known as "prediction-powered inference" (PPI) involve (i) applying a pre-trained machine learning model to predict the response, and then (ii) using these predictions to…

Methodology · Statistics 2026-02-12 Runjia Zou , Daniela Witten , Brian Williamson
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