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The advancement of Large Language Models (LLMs) has significantly impacted biomedical Natural Language Processing (NLP), enhancing tasks such as named entity recognition, relation extraction, event extraction, and text classification. In…

Computation and Language · Computer Science 2025-03-04 Zaifu Zhan , Shuang Zhou , Huixue Zhou , Jiawen Deng , Yu Hou , Jeremy Yeung , Rui Zhang

Despite the widespread success of self-supervised learning via masked language models (MLM), accurately capturing fine-grained semantic relationships in the biomedical domain remains a challenge. This is of paramount importance for…

Computation and Language · Computer Science 2021-04-08 Fangyu Liu , Ehsan Shareghi , Zaiqiao Meng , Marco Basaldella , Nigel Collier

Tokenizer adaptation plays an important role in adapting pre-trained language models to new domains or languages. In this work, we address two complementary aspects of this process: vocabulary extension and pruning. The common approach to…

Computation and Language · Computer Science 2026-03-24 Taido Purason , Pavel Chizhov , Ivan P. Yamshchikov , Mark Fishel

Masked language modeling (MLM) is one of the key sub-tasks in vision-language pretraining. In the cross-modal setting, tokens in the sentence are masked at random, and the model predicts the masked tokens given the image and the text. In…

Computation and Language · Computer Science 2021-09-07 Yonatan Bitton , Gabriel Stanovsky , Michael Elhadad , Roy Schwartz

Large Language Models (LLMs) have demonstrated remarkable performance across various domains, including healthcare. However, their ability to effectively represent structured non-textual data, such as the alphanumeric medical codes used in…

The availability of biomedical text data and advances in natural language processing (NLP) have made new applications in biomedical NLP possible. Language models trained or fine tuned using domain specific corpora can outperform general…

Computation and Language · Computer Science 2021-07-12 Usman Naseem , Adam G. Dunn , Matloob Khushi , Jinman Kim

Language models (LMs) have demonstrated remarkable capabilities in NLP, yet adapting them efficiently and robustly to specific tasks remains challenging. As their scale and complexity grow, fine-tuning LMs on labelled data often…

Computation and Language · Computer Science 2025-06-27 Zhengyan Shi

This paper investigates the challenges of developing large language models (LLMs) proficient in both multilingual understanding and medical knowledge. We demonstrate that simply translating medical data does not guarantee strong performance…

Computation and Language · Computer Science 2025-01-20 Nada Saadi , Tathagata Raha , Clément Christophe , Marco AF Pimentel , Ronnie Rajan , Praveen K Kanithi

Tokenization is a necessary component within the current architecture of many language mod-els, including the transformer-based large language models (LLMs) of Generative AI, yet its impact on the model's cognition is often overlooked. We…

Biomedical named entity recognition (BNER) serves as the foundation for numerous biomedical text mining tasks. Unlike general NER, BNER require a comprehensive grasp of the domain, and incorporating external knowledge beyond training data…

Computation and Language · Computer Science 2023-07-06 Junyi Bian , Rongze Jiang , Weiqi Zhai , Tianyang Huang , Hong Zhou , Shanfeng Zhu

The assumption across nearly all language model (LM) tokenization schemes is that tokens should be subwords, i.e., contained within word boundaries. While providing a seemingly reasonable inductive bias, is this common practice limiting the…

Computation and Language · Computer Science 2025-08-28 Alisa Liu , Jonathan Hayase , Valentin Hofmann , Sewoong Oh , Noah A. Smith , Yejin Choi

Pre-trained language models (PLMs), such as BERT and GPT, have revolutionized the field of NLP, not only in the general domain but also in the biomedical domain. Most prior efforts in building biomedical PLMs have resorted simply to domain…

Computation and Language · Computer Science 2022-03-03 Quan Wang , Songtai Dai , Benfeng Xu , Yajuan Lyu , Yong Zhu , Hua Wu , Haifeng Wang

Large language model (LLM) tokenizers act as structured compressors: by mapping text to discrete token sequences, they determine token count (and thus compute and context usage) and the statistical structure seen by downstream models.…

Information Theory · Computer Science 2026-01-15 Mete Erdogan , Abhiram Gorle , Shubham Chandak , Mert Pilanci , Tsachy Weissman

Large Language Models (LLMs) have been widely applied in various professional fields. By fine-tuning the models using domain specific question and answer datasets, the professional domain knowledge and Q\&A abilities of these models have…

Computation and Language · Computer Science 2024-07-17 Qimin Yang , Rongsheng Wang , Jiexin Chen , Runqi Su , Tao Tan

Deep transformer neural network models have improved the predictive accuracy of intelligent text processing systems in the biomedical domain. They have obtained state-of-the-art performance scores on a wide variety of biomedical and…

Computation and Language · Computer Science 2021-11-17 Milad Moradi , Matthias Samwald

Pre-trained language models (LMs) have become ubiquitous in solving various natural language processing (NLP) tasks. There has been increasing interest in what knowledge these LMs contain and how we can extract that knowledge, treating LMs…

Computation and Language · Computer Science 2021-09-16 Mujeen Sung , Jinhyuk Lee , Sean Yi , Minji Jeon , Sungdong Kim , Jaewoo Kang

The widespread application of pre-trained language models (PLMs) in natural language processing (NLP) has led to increasing concerns about their explainability. Selective rationalization is a self-explanatory framework that selects…

Computation and Language · Computer Science 2025-01-07 Libing Yuan , Shuaibo Hu , Kui Yu , Le Wu

Tokenization is fundamental to Natural Language Processing (NLP), directly impacting model efficiency and linguistic fidelity. While Byte Pair Encoding (BPE) is widely used in Large Language Models (LLMs), it often disregards morpheme…

Computation and Language · Computer Science 2025-02-04 Ehsaneddin Asgari , Yassine El Kheir , Mohammad Ali Sadraei Javaheri

Developing high-performance entity normalization algorithms that can alleviate the term variation problem is of great interest to the biomedical community. Although deep learning-based methods have been successfully applied to biomedical…

Information Retrieval · Computer Science 2019-08-12 Zongcheng Ji , Qiang Wei , Hua Xu

Extracting detailed clinical information from free-text medical narratives remains a practical challenge for researchers and healthcare systems. Terminology for immune-mediated and infectious diseases is especially inconsistent across…

Computation and Language · Computer Science 2026-05-29 Veysel Kocaman , Gursev Pirge , Yigit Gul , Ace Vo , Zhenya Nargizyan , David Talby
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