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Many applications in genetic analyses utilize sampling distributions, which describe the probability of observing a sample of DNA sequences randomly drawn from a population. In the one-locus case with special models of mutation such as the…

Probability · Mathematics 2012-07-25 Anand Bhaskar , John A. Kamm , Yun S. Song

Consider an urn filled with balls, each labeled with one of several possible collective decisions. Now, let a random voter draw two balls from the urn and pick her more preferred as the collective decision. Relabel the losing ball with the…

Theoretical Economics · Economics 2024-03-28 Florian Brandl , Felix Brandt

The gambler's ruin problem for correlated random walks (CRW), both with and without delays, is addressed using the Optional Stopping Theorem for martingales. We derive closed-form expressions for the ruin probabilities and the expected game…

Probability · Mathematics 2025-06-03 Vladimir Pozdnyakov

Mathematical models of the real world are simplified representations of complex systems. A caveat to using mathematical models is that predicted causal effects and conditional independences may not be robust under model extensions, limiting…

Methodology · Statistics 2022-08-30 Tineke Blom , Joris M. Mooij

Maximum entropy random walks (MERWs) are maximally dispersing and play a key role in optimizing information spreading in various contexts. However, building MERWs comes at the cost of knowing beforehand the global structure of the network,…

Statistical Mechanics · Physics 2023-01-24 Gabriele Di Bona , Leonardo Di Gaetano , Vito Latora , Francesco Coghi

Mutations sometimes increase contagiousness for evolving pathogens. During an epidemic, scientists use viral genome data to infer a shared evolutionary history and connect this history to geographic spread. We propose a model that directly…

Populations and Evolution · Quantitative Biology 2021-09-14 Andrew J. Holbrook , Xiang Ji , Marc A. Suchard

We consider P\'olya urns with infinitely many colours that are of a random walk type, in two related version. We show that the colour distribution a.s., after rescaling, converges to a normal distribution, assuming only second moments on…

Probability · Mathematics 2018-03-13 Svante Janson

Computational models for the simulation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic evolution would be extremely useful to support authorities in designing healthcare policies and lockdown measures to…

Populations and Evolution · Quantitative Biology 2020-04-20 Marco Paggi

We study the distribution of entries of a random permutation matrix under a "randomized basis," i.e., we conjugate the random permutation matrix by an independent random orthogonal matrix drawn from Haar measure. It is shown that under…

Probability · Mathematics 2019-05-08 Benjamin Tsou

Mendelian randomization (MR) is a powerful method that uses genetic variants as instrumental variables (IVs) to infer the causal effect of a modifiable exposure on an outcome. Although recent years have seen many extensions of basic MR…

Methodology · Statistics 2022-03-15 Sai Li , Ting Ye

In Mendelian randomization (MR) studies, genetic variants are used as instrumental variables (IVs) to investigate causal relationships between exposures and outcomes based on observational data. However, numerous genetic studies have shown…

Methodology · Statistics 2026-04-10 Julien St-Pierre , Archer Y. Yang , Mireille E. Schnitzer , Marc-André Legault

The inverse probability weighting (IPW) method is used to handle attrition in association analyses derived from cohort studies. It consists in weighting the respondents at a given follow-up by their inverse probability to participate.…

Applications · Statistics 2021-05-05 Marie-Astrid Metten , Nathalie Costet , J. -F. Viel , Guillaume Chauvet

We describe an new algorithm for visualizing an alignment of biological sequences according to a probabilistic model of evolution. The resulting data array is readily interpreted by the human eye and amenable to digital image techniques. We…

Populations and Evolution · Quantitative Biology 2007-05-23 Lawren Smithline

We calculate the probability distribution of repetitions of ancestors in a genealogical tree for simple neutral models of a closed population with sexual reproduction and non-overlapping generations. Each ancestor at generation g in the…

Condensed Matter · Physics 2009-10-31 B. Derrida , S. C. Manrubia , D. H. Zanette

Randomized smoothing (RS) is one of the prominent techniques to ensure the correctness of machine learning models, where point-wise robustness certificates can be derived analytically. While RS is well understood for classification, its…

Machine Learning · Computer Science 2025-09-22 Emmanouil Seferis , Changshun Wu , Stefanos Kollias , Saddek Bensalem , Chih-Hong Cheng

We consider the problem of model building for rare events prediction in longitudinal follow-up studies. In this paper, we compare several resampling methods to improve standard regression models on a real life example. We evaluate the…

Methodology · Statistics 2023-06-21 Pierre Druilhet , Mathieu Berthe , Stéphanie Léger

We consider weighted negatively reinforced urn schemes with finitely many colours. An urn scheme is called negatively reinforced, if the selection probability for a colour is proportional to the weight $w$ of the colour proportion, where…

Probability · Mathematics 2019-05-28 Gursharn Kaur

In this note, we show how the penalization method, introduced in order to describe some non-trivial changes of the Wiener measure, can be applied to the study of some simple polymer models such as the pinning model. The bulk of the analysis…

Probability · Mathematics 2007-09-18 Mihai Gradinaru , Samy Tindel

Micro-randomized trials are commonly conducted for optimizing mobile health interventions such as push notifications for behavior change. In analyzing such trials, causal excursion effects are often of primary interest, and their estimation…

Methodology · Statistics 2024-08-19 Yihan Bao , Lauren Bell , Elizabeth Williamson , Claire Garnett , Tianchen Qian

The numerical stochastic perturbation method based on Parisi-Wu quantisation is applied to a suite of simple models to test its validity at high orders. Large deviations from normal distribution for the basic estimators are systematically…

High Energy Physics - Lattice · Physics 2009-10-31 R. Alfieri , F. Di Renzo , E. Onofri , L. Scorzato