From viral evolution to spatial contagion: a biologically modulated Hawkes model
Abstract
Mutations sometimes increase contagiousness for evolving pathogens. During an epidemic, scientists use viral genome data to infer a shared evolutionary history and connect this history to geographic spread. We propose a model that directly relates a pathogen's evolution to its spatial contagion dynamics -- effectively combining the two epidemiological paradigms of phylogenetic inference and self-exciting process modeling -- and apply this \emph{phylogenetic Hawkes process} to a Bayesian analysis of 23,422 viral cases from the 2014-2016 Ebola outbreak in West Africa. The proposed model is able to detect individual viruses with significantly elevated rates of spatiotemporal propagation for a subset of 1,610 samples that provide genome data. Finally, to facilitate model application in big data settings, we develop massively parallel implementations for the gradient and Hessian of the log-likelihood and apply our high performance computing framework within an adaptively preconditioned Hamiltonian Monte Carlo routine.
Cite
@article{arxiv.2103.03348,
title = {From viral evolution to spatial contagion: a biologically modulated Hawkes model},
author = {Andrew J. Holbrook and Xiang Ji and Marc A. Suchard},
journal= {arXiv preprint arXiv:2103.03348},
year = {2021}
}