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The first step in Multiple Instance Learning (MIL) algorithms for Whole Slide Image (WSI) classification consists of tiling the input image into smaller patches and computing their feature vectors produced by a pre-trained feature extractor…

Computer Vision and Pattern Recognition · Computer Science 2024-03-11 Juan I. Pisula , Katarzyna Bozek

Fine-grained classification of whole slide images (WSIs) is essential in precision oncology, enabling precise cancer diagnosis and personalized treatment strategies. The core of this task involves distinguishing subtle morphological…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Cheng Jin , Luyang Luo , Huangjing Lin , Jun Hou , Hao Chen

Multiple instance learning (MIL) stands as a powerful approach in weakly supervised learning, regularly employed in histological whole slide image (WSI) classification for detecting tumorous lesions. However, existing mainstream MIL methods…

Image and Video Processing · Electrical Eng. & Systems 2024-07-08 Wenhui Zhu , Xiwen Chen , Peijie Qiu , Aristeidis Sotiras , Abolfazl Razi , Yalin Wang

Recently, a number of image-mixing-based augmentation techniques have been introduced to improve the generalization of deep neural networks. In these techniques, two or more randomly selected natural images are mixed together to generate an…

Computer Vision and Pattern Recognition · Computer Science 2024-05-27 Khawar Islam , Muhammad Zaigham Zaheer , Arif Mahmood , Karthik Nandakumar

Multiple Instance Learning (MIL) and transformers are increasingly popular in histopathology Whole Slide Image (WSI) classification. However, unlike human pathologists who selectively observe specific regions of histopathology tissues under…

Computer Vision and Pattern Recognition · Computer Science 2023-07-18 Conghao Xiong , Hao Chen , Joseph J. Y. Sung , Irwin King

Multiple instance learning (MIL) has become the leading approach for extracting discriminative features from whole slide images (WSIs) in computational pathology. Attention-based MIL methods can identify key patches but tend to overlook…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Lubin Gan , Xiaoman Wu , Jing Zhang , Zhifeng Wang , Linhao Qu , Siying Wu , Xiaoyan Sun

Mixup~\cite{zhang2017mixup} is a recently proposed method for training deep neural networks where additional samples are generated during training by convexly combining random pairs of images and their associated labels. While simple to…

Machine Learning · Statistics 2020-01-08 Sunil Thulasidasan , Gopinath Chennupati , Jeff Bilmes , Tanmoy Bhattacharya , Sarah Michalak

In recent years, the availability of digitized Whole Slide Images (WSIs) has enabled the use of deep learning-based computer vision techniques for automated disease diagnosis. However, WSIs present unique computational and algorithmic…

Image and Video Processing · Electrical Eng. & Systems 2021-06-15 Yash Sharma , Aman Shrivastava , Lubaina Ehsan , Christopher A. Moskaluk , Sana Syed , Donald E. Brown

We propose a new formulation of Multiple-Instance Learning (MIL), in which a unit of data consists of a set of instances called a bag. The goal is to find a good classifier of bags based on the similarity with a "shapelet" (or pattern),…

Machine Learning · Computer Science 2020-10-14 Daiki Suehiro , Kohei Hatano , Eiji Takimoto , Shuji Yamamoto , Kenichi Bannai , Akiko Takeda

While deep neural networks achieve great performance on fitting the training distribution, the learned networks are prone to overfitting and are susceptible to adversarial attacks. In this regard, a number of mixup based augmentation…

Machine Learning · Computer Science 2021-01-01 Jang-Hyun Kim , Wonho Choo , Hyun Oh Song

Training deep neural networks requires datasets with a large number of annotated examples. The collection and annotation of these datasets is not only extremely expensive but also faces legal and privacy problems. These factors are a…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Christoph Reinders , Frederik Schubert , Bodo Rosenhahn

In the application of Multiple Instance Learning (MIL) methods for Whole Slide Image (WSI) classification, attention mechanisms often focus on a subset of discriminative instances, which are closely linked to overfitting. To mitigate…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Yunlong Zhang , Honglin Li , Yuxuan Sun , Sunyi Zheng , Chenglu Zhu , Lin Yang

Multiple instance learning (MIL) problem is currently solved from either bag-classification or instance-classification perspective, both of which ignore important information contained in some instances and result in limited performance.…

Computer Vision and Pattern Recognition · Computer Science 2024-08-12 Yingfan Ma , Xiaoyuan Luo , Mingzhi Yuan , Xinrong Chen , Manning Wang

Large deep networks have demonstrated competitive performance in single image super-resolution (SISR), with a huge volume of data involved. However, in real-world scenarios, due to the limited accessible training pairs, large models exhibit…

Computer Vision and Pattern Recognition · Computer Science 2019-06-13 Ruicheng Feng , Jinjin Gu , Yu Qiao , Chao Dong

The recently advanced unsupervised learning approaches use the siamese-like framework to compare two "views" from the same image for learning representations. Making the two views distinctive is a core to guarantee that unsupervised methods…

Computer Vision and Pattern Recognition · Computer Science 2022-02-18 Zhiqiang Shen , Zechun Liu , Zhuang Liu , Marios Savvides , Trevor Darrell , Eric Xing

Multiple instance learning (MIL) was a weakly supervised learning approach that sought to assign binary class labels to collections of instances known as bags. However, due to their weak supervision nature, the MIL methods were susceptible…

Computer Vision and Pattern Recognition · Computer Science 2024-05-27 Wenhui Zhu , Peijie Qiu , Xiwen Chen , Oana M. Dumitrascu , Yalin Wang

Recently contrastive learning has shown significant progress in learning visual representations from unlabeled data. The core idea is training the backbone to be invariant to different augmentations of an instance. While most methods only…

Computer Vision and Pattern Recognition · Computer Science 2021-11-05 Xiaoyang Guo , Tianhao Zhao , Yutian Lin , Bo Du

Data augmentation improves the generalization power of deep learning models by synthesizing more training samples. Sample-mixing is a popular data augmentation approach that creates additional data by combining existing samples. Recent…

Computer Vision and Pattern Recognition · Computer Science 2024-03-20 Tsz-Him Cheung , Dit-Yan Yeung

Masked Image Modeling (MIM) has achieved promising progress with the advent of Masked Autoencoders (MAE) and BEiT. However, subsequent works have complicated the framework with new auxiliary tasks or extra pre-trained models, inevitably…

Computer Vision and Pattern Recognition · Computer Science 2023-03-27 Yuan Liu , Songyang Zhang , Jiacheng Chen , Kai Chen , Dahua Lin

Data mixing augmentation have proved to be effective in improving the generalization ability of deep neural networks. While early methods mix samples by hand-crafted policies (e.g., linear interpolation), recent methods utilize saliency…

Computer Vision and Pattern Recognition · Computer Science 2022-09-23 Zicheng Liu , Siyuan Li , Di Wu , Zihan Liu , Zhiyuan Chen , Lirong Wu , Stan Z. Li
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