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Brain imaging of mental health, neurodevelopmental and learning disorders has coupled with machine learning to identify patients based only on their brain activation, and ultimately identify features that generalize from smaller samples of…
Pathological brain appearances may be so heterogeneous as to be intelligible only as anomalies, defined by their deviation from normality rather than any specific pathological characteristic. Amongst the hardest tasks in medical imaging,…
For the brain to recognize local orientations within images, neurons must spontaneously break the translation and rotation symmetry of their response functions -- an archetypal example of unsupervised learning. The dominant framework for…
Unsupervised anomaly detection in brain imaging is challenging. In this paper, we propose self-supervised masked mesh learning for unsupervised anomaly detection on 3D cortical surfaces. Our framework leverages the intrinsic geometry of the…
In clinical practice, medical segmentation datasets are often limited and heterogeneous, with variations in modalities, protocols, and anatomical targets across institutions. Existing deep learning models struggle to jointly learn from such…
Hippocampal atrophy in Alzheimer's disease (AD) is asymmetric and spatially inhomogeneous. While extensive work has been done on volume and shape analysis of atrophy of the hippocampus in AD, less attention has been given to hippocampal…
Synthetic training has recently advanced brain MRI segmentation by enabling contrast-agnostic models trained entirely on generated data. However, most existing approaches rely on hundreds of automatically labeled templates, introducing…
We explore encoding brain symmetry into a neural network for a brain tumor segmentation task. A healthy human brain is symmetric at a high level of abstraction, and the high-level asymmetric parts are more likely to be tumor regions. Paying…
To study neurodegenerative diseases, longitudinal studies are carried on volunteer patients. During a time span of several months to several years, they go through regular medical visits to acquire data from different modalities, such as…
Human bodies exhibit various shapes for different identities or poses, but the body shape has certain similarities in structure and thus can be embedded in a low-dimensional space. This paper presents an autoencoder-like network…
Radiomic representations can quantify properties of regions of interest in medical image data. Classically, they account for pre-defined statistics of shape, texture, and other low-level image features. Alternatively, deep learning-based…
Catastrophic forgetting is a critical challenge in training deep neural networks. Although continual learning has been investigated as a countermeasure to the problem, it often suffers from the requirements of additional network components…
Melanoma brain metastases (MBM) are common and spatially heterogeneous lesions, complicating cohort-level analyses due to anatomical variability and differing MRI protocols. We propose a fully differentiable, deep-learning-based deformable…
The differential diagnosis of neurodegenerative diseases, characterized by overlapping symptoms, may be challenging. Brain imaging coupled with artificial intelligence has been previously proposed for diagnostic support, but most of these…
Brain lesions, including stroke and tumours, have a high degree of variability in terms of location, size, intensity and form, making automatic segmentation difficult. We propose an improvement to existing segmentation methods by exploiting…
Autism Spectrum Disorder(ASD) is a set of neurodevelopmental conditions that affect patients' social abilities. In recent years, many studies have employed deep learning to diagnose this brain dysfunction through functional MRI (fMRI).…
Machine learning-based medical anomaly detection is an important problem that has been extensively studied. Numerous approaches have been proposed across various medical application domains and we observe several similarities across these…
Anomaly detection on attributed networks aims at finding nodes whose patterns deviate significantly from the majority of reference nodes, which is pervasive in many applications such as network intrusion detection and social spammer…
Quantifying similarity between neural representations -- e.g. hidden layer activation vectors -- is a perennial problem in deep learning and neuroscience research. Existing methods compare deterministic responses (e.g. artificial networks…
We develop a Bayesian bivariate spatial model for multivariate regression analysis applicable to studies examining the influence of genetic variation on brain structure. Our model is motivated by an imaging genetics study of the Alzheimer's…