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High-resolution functional imaging is providing increasingly rich measurements of brain activity in animals and humans. A major challenge is to leverage such data to gain insight into the brain's computational mechanisms. The first step is…

Neurons and Cognition · Quantitative Biology 2016-08-09 Nikolaus Kriegeskorte , Jörn Diedrichsen

In this work we focus on examination and comparison of whole-brain functional connectivity patterns measured with fMRI across experimental conditions. Direct examination and comparison of condition-specific matrices is challenging due to…

Applications · Statistics 2013-01-02 Svetlana V. Shinkareva , Vladimir Gudkov , Jing Wang

Many analyses of functional magnetic resonance imaging (fMRI) examine functional connectivity (FC), or the statistical dependencies among distant brain regions. These analyses are typically exploratory, guiding future confirmatory research.…

Applications · Statistics 2025-10-20 Kyle Stanley , Nicole Lazar , Matthew Reimherr

Cognitive brain imaging is accumulating datasets about the neural substrate of many different mental processes. Yet, most studies are based on few subjects and have low statistical power. Analyzing data across studies could bring more…

Machine Learning · Statistics 2021-05-20 Arthur Mensch , Julien Mairal , Bertrand Thirion , Gaël Varoquaux

A suitable feature representation that can both preserve the data intrinsic information and reduce data complexity and dimensionality is key to the performance of machine learning models. Deeply rooted in algebraic topology, persistent…

Algebraic Topology · Mathematics 2018-11-02 Chi Seng Pun , Kelin Xia , Si Xian Lee

The extent to which different biological and artificial neural systems rely on equivalent internal representations to support similar tasks remains a central question in neuroscience and machine learning. Prior work typically compares…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Jialin Wu , Shreya Saha , Yiqing Bo , Meenakshi Khosla

There is a growing body of work that leverages features extracted via topological data analysis to train machine learning models. While this field, sometimes known as topological machine learning (TML), has seen some notable successes, an…

Machine Learning · Computer Science 2022-11-16 Sarah McGuire , Shane Jackson , Tegan Emerson , Henry Kvinge

Functional MRI (fMRI) is crucial for studying brain function and diagnosing neurological disorders. However, existing analysis methods suffer from reproducibility and transferability challenges due to complex preprocessing pipelines and…

Representation learning on graphs is a fundamental problem that can be crucial in various tasks. Graph neural networks, the dominant approach for graph representation learning, are limited in their representation power. Therefore, it can be…

Machine Learning · Computer Science 2025-01-17 Zuoyu Yan , Qi Zhao , Ze Ye , Tengfei Ma , Liangcai Gao , Zhi Tang , Yusu Wang , Chao Chen

Functional magnetic resonance imaging (fMRI) is a neuroimaging technique that records neural activations in the brain by capturing the blood oxygen level in different regions based on the task performed by a subject. Given fMRI data, the…

Computer Vision and Pattern Recognition · Computer Science 2021-09-21 Ashish Jaiswal , Ashwin Ramesh Babu , Mohammad Zaki Zadeh , Fillia Makedon , Glenn Wylie

Structural magnetic resonance imaging (sMRI) provides accurate estimates of the brain's structural organization and learning invariant brain representations from sMRI is an enduring issue in neuroscience. Previous deep representation…

Computer Vision and Pattern Recognition · Computer Science 2023-06-21 Ning Jiang , Gongshu Wang , Tianyi Yan

The vast majority of fMRI studies of task-related brain activity utilize common levels of task demands and analyses that rely on the central tendencies of the data. This approach does not take into account perceived difficulty nor regional…

Neurons and Cognition · Quantitative Biology 2021-10-14 Jason Steffener , Chris Habeck , Dylan Franklin , Meghan Lau , Yara Yakoub , Maryse Gad

Functional magnetic resonance imaging (fMRI) is a powerful tool for investigating human brain function. However, the high cost of data acquisition and the inherent subjectivity of psychiatric rating scales often lead to datasets with small…

Machine Learning · Computer Science 2026-05-29 Jiyao Wang , Peiyu Duan , Nicha C. Dvornek , Lawrence H. Staib , Denis Sukhodolsky , Pamela Ventola , James S. Duncan

Neural networks can be thought of as applying a transformation to an input dataset. The way in which they change the topology of such a dataset often holds practical significance for many tasks, particularly those demanding non-homeomorphic…

Machine Learning · Computer Science 2024-06-05 Kosio Beshkov , Gaute T. Einevoll

Whole brain neuroanatomy using tera-voxel light-microscopic data sets is of much current interest. A fundamental problem in this field is the mapping of individual brain data sets to a reference space. Previous work has not rigorously…

Neurons and Cognition · Quantitative Biology 2019-04-18 Brian C. Lee , Meng Kuan Lin , Yan Fu , Junichi Hata , Michael I. Miller , Partha P. Mitra

Functional Magnetic Resonance Imaging~(fMRI) is widely used to study activation in the human brain. In most cases, data are commonly used to construct activation maps corresponding to a given paradigm. Results can be very variable, hence…

Applications · Statistics 2022-05-04 Ranjan Maitra

Interactions between the brain and body are of fundamental importance for human behavior and health. Functional magnetic resonance imaging (fMRI) captures whole-brain activity noninvasively, and modeling how fMRI signals interact with…

We analyze functional magnetic resonance imaging (fMRI) data from the Human Connectome Project (HCP) to match brain activities during a range of cognitive tasks. Our findings demonstrate that even basic linear machine learning models can…

Neurons and Cognition · Quantitative Biology 2025-10-08 Valeriya Kirova , Dzerassa Kadieva , Daniil Vlasenko , Isak B. Blank , Fedor Ratnikov

All neuroimaging modalities have their own strengths and limitations. A current trend is toward interdisciplinary approaches that use multiple imaging methods to overcome limitations of each method in isolation. At the same time…

Methodology · Statistics 2023-03-30 Pratim Guha Niyogi , Martin A. Lindquist , Tapabrata Maiti

Functional magnetic resonance imaging (fMRI) is widely used for studying and diagnosing brain disorders, with functional connectivity (FC) matrices providing powerful representations of large-scale neural interactions. However, existing…

Tissues and Organs · Quantitative Biology 2026-04-17 Qianyu Chen , Shujian Yu