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Finding optimal policies to reduce the morbidity and mortality of the ongoing pandemic is a top public health priority. Using a compartmental model with age structure and vaccination status, we examined the effect of age specific scheduling…

Populations and Evolution · Quantitative Biology 2012-02-29 Diána Knipl , Gergely Röst

This paper considers a mathematical model based on the transmission dynamics of hepatitis C virus (HCV) infection. In addition to the usual compartments for susceptible, exposed, and infected individuals, this model includes compartments…

Populations and Evolution · Quantitative Biology 2017-12-25 Daniah Tahir , Abid Ali Lashari , Kazeem Oare Okosun

Global strategies to contain a pandemic, such as social distancing and protective measures, are designed to reduce the overall transmission rate between individuals. Despite such measures, essential institutions, including hospitals,…

Populations and Evolution · Quantitative Biology 2022-09-07 Roberto Morán-Tovar , Henning Gruell , Florian Klein , Michael Lässig

We consider the interplay of vaccination and migration rates on disease persistence in epidemiological systems. We show that short-term and long-term migration can inhibit disease persistence. As a result, we show how migration changes how…

Biological Physics · Physics 2012-05-22 Jackson Burton , Lora Billings , Derek A. T. Cummings , Ira B. Schwartz

We consider optimal vaccination protocol where the vaccine is in short supply. In this case, disease extinction results from a large and rare fluctuation. We show that the probability of such fluctuation can be exponentially increased by…

Populations and Evolution · Quantitative Biology 2013-05-29 M. Khasin , M. I. Dykman , B. Meerson

Voluntary vaccination is essential to protect oneself from infection and suppress the spread of infectious diseases. Voluntary vaccination behavior is influenced by factors such as age and interaction patterns. Differences in health…

Physics and Society · Physics 2024-12-11 Yanyi Nie , Tao Lin , Yanbing Liu , Wei Wang

Efficient testing and vaccination protocols are critical aspects of epidemic management. To study the optimal allocation of limited testing and vaccination resources in a heterogeneous contact network of interacting susceptible, recovered,…

Populations and Evolution · Quantitative Biology 2026-05-12 Mingtao Xia , Lucas Böttcher , Tom Chou

The COVID-19 pandemic led to widespread interest in epidemiological models. In this context the role of vaccination in influencing the spreading of the disease is of particular interest. There has also been a lot of debate on the role of…

Dynamical Systems · Mathematics 2023-07-25 Aytül Gökçe , Burcu Gürbüz , Alan D. Rendall

In previous articles, we formalized the problem of optimal allocation strategies for a (perfect) vaccine in an infinite-dimensional metapopulation model. The aim of the current paper is to illustrate this theoretical framework with multiple…

Optimization and Control · Mathematics 2021-12-17 Jean-François Delmas , Dylan Dronnier , Pierre-André Zitt

Given limited supply of approved vaccines and constrained medical resources, design of a vaccination strategy to control a pandemic is an economic problem. We use time-series and panel methods with real-world country-level data to estimate…

General Economics · Economics 2022-01-19 Dongwoo Kim , Young Jun Lee

During the Covid-19 pandemic a key role is played by vaccination to combat the virus. There are many possible policies for prioritizing vaccines, and different criteria for optimization: minimize death, time to herd immunity, functioning of…

Populations and Evolution · Quantitative Biology 2022-03-18 Qi Luo , Ryan Weightman , Sean T. McQuade , Mateo Diaz , Emmanuel Trélat , William Barbour , Dan Work , Samitha Samaranayake , Benedetto Piccoli

We consider a SIR model with temporary immunity and time dependent transmission rate. We assume time dependent vaccination which confers the same immunity as natural infection. We study two types of vaccination strategies: i) optimal…

Populations and Evolution · Quantitative Biology 2016-04-06 Paulo Doutor , Paula Rodrigues , Maria do Céu Soares , Fabio A. C. C. Chalub

The containment of epidemic spreading is a major challenge in science. Vaccination, whenever available, is the best way to prevent the spreading, because it eventually immunizes individuals. However, vaccines are not perfect, and total…

A new age-distributed immuno-epidemiological model with information-based vaccine uptake suggested in this work represents a system of integro-differential equations for the numbers of susceptible individuals, infected individuals,…

Populations and Evolution · Quantitative Biology 2024-04-02 Samiran Ghosh , Malay Banerjee , Vitaly Volpert

Celebrities can significantly influence the public towards any desired outcome. In a bid to tackle an infectious disease, a leader (government) exploits such influence towards motivating a fraction of public to get vaccinated, sufficient…

Optimization and Control · Mathematics 2023-04-07 Vartika Singh , Veeraruna Kavitha

We propose a system theoretic approach to select and stabilize the endemic equilibrium of an SIRS epidemic model in which the decisions of a population of strategically interacting agents determine the transmission rate. Specifically, the…

Dynamical Systems · Mathematics 2022-01-26 Nuno C. Martins , Jair Certorio , Richard J. La

The effectiveness of vaccination highly depends on the choice of individuals to vaccinate, even if the same number of individuals are vaccinated. Vaccinating individuals with high centrality measures such as betweenness centrality (BC) and…

Physics and Society · Physics 2021-12-30 Bukyoung Jhun

This paper is a survey paper on stochastic epidemic models. A simple stochastic epidemic model is defined and exact and asymptotic model properties (relying on a large community) are presented. The purpose of modelling is illustrated by…

Probability · Mathematics 2009-11-05 Tom Britton

We study in a general mathematical framework the optimal allocation of vaccine in an heterogeneous population. We cast the problem of optimal vaccination as a bi-objective minimization problem min(C($\eta$),L($\eta$)), where C and L stand…

Optimization and Control · Mathematics 2025-03-21 Jean-François Delmas , Dylan Dronnier , Pierre-André Zitt

We use analytical methods to investigate a continuous vaccination strategy effects on the infectious disease dynamics in a closed population and a demographically open population. The methodology and key assumptions are based on Breda et al…

Populations and Evolution · Quantitative Biology 2020-09-24 Aubain Nzokem , Neal Madras