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The increased availability of time series genetic variation data from experimental evolution studies and ancient DNA samples has created new opportunities to identify genomic regions under selective pressure and to estimate their associated…

Populations and Evolution · Quantitative Biology 2015-01-27 Matthias Steinrücken , Anand Bhaskar , Yun S. Song

According to the No Free Lunch (NFL) theorems all black-box algorithms perform equally well when compared over the entire set of optimization problems. An important problem related to NFL is finding a test problem for which a given…

Neural and Evolutionary Computing · Computer Science 2021-09-29 Mihai Oltean

We consider the problem of estimating a low-rank matrix from a noisy observed matrix. Previous work has shown that the optimal method depends crucially on the choice of loss function. In this paper, we use a family of weighted loss…

Statistics Theory · Mathematics 2021-04-08 William Leeb

In this paper we study the complexity of quantum query algorithms computing the value of Boolean function and its relation to the degree of algebraic polynomial representing this function. We pay special attention to Boolean functions with…

Quantum Physics · Physics 2012-03-24 Alina Dubrovska Vasilieva , Taisija Mischenko-Slatenkova

The paper studies machine learning problems where each example is described using a set of Boolean features and where hypotheses are represented by linear threshold elements. One method of increasing the expressiveness of learned hypotheses…

Machine Learning · Computer Science 2011-09-13 R. Khardon , D. Roth , R. A. Servedio

We study combinatorial properties of plateaued functions $F \colon \mathbb{F}_p^n \rightarrow \mathbb{F}_p^m$. All quadratic functions, bent functions and most known APN functions are plateaued, so many cryptographic primitives rely on…

Combinatorics · Mathematics 2026-03-26 Lukas Kölsch , Alexandr Polujan

The capability of accurate prediction of protein functions and properties is essential in the biotechnology industry, e.g. drug development and artificial protein synthesis, etc. The main challenges of protein function prediction are the…

Quantitative Methods · Quantitative Biology 2021-12-02 Wei-Cheng Tseng , Po-Han Chi , Jia-Hua Wu , Min Sun

We investigate how classifiers for Boolean networks (BNs) can be constructed and modified under constraints. A typical constraint is to observe only states in attractors or even more specifically steady states of BNs. Steady states of BNs…

Commutative Algebra · Mathematics 2021-08-20 Robert Schwieger , Matías R. Bender , Heike Siebert , Christian Haase

We develop a method for training neural networks on Boolean data in which the values at all nodes are strictly $\pm 1$, and the resulting models are typically equivalent to networks whose nonzero weights are also $\pm 1$. The method…

Machine Learning · Computer Science 2026-02-20 Veit Elser , Manish Krishan Lal

In this paper, by mapping datasets to a set of non-linear coherent states, the process of encoding inputs in quantum states as a non-linear feature map is re-interpreted. As a result of this fact that the Radial Basis Function is recovered…

Quantum Physics · Physics 2020-07-17 Prayag Tiwari , Shahram Dehdashti , Abdul Karim Obeid , Massimo Melucci , Peter Bruza

Gene regulatory networks (GRNs) are increasingly used for explaining biological processes with complex transcriptional regulation. A GRN links the expression levels of a set of genes via regulatory controls that gene products exert on one…

Molecular Networks · Quantitative Biology 2016-06-21 Guy Karlebach

We propose a flexible nonparametric regression method for ultrahigh-dimensional data. As a first step, we propose a fast screening method based on the favored smoothing bandwidth of the marginal local constant regression. Then, an iterative…

Methodology · Statistics 2018-07-30 Yang Feng , Yichao Wu , Leonard Stefanski

In this paper, we consider functionals based on moments and non-linear entropies which have a linear growth in time in case of source-type so-lutions to the fast diffusion or porous medium equations, that are also known as Barenblatt…

Analysis of PDEs · Mathematics 2015-01-16 Jean Dolbeault , Giuseppe Toscani

By removing irrelevant and redundant features, feature selection aims to find a good representation of the original features. With the prevalence of unlabeled data, unsupervised feature selection has been proven effective in alleviating the…

Machine Learning · Computer Science 2024-03-25 Ziyuan Lin , Deanna Needell

We have developed an algorithm for non-parametric fitting and extraction of statistically significant peaks in the presence of statistical and systematic uncertainties. Applications of this algorithm for analysis of high-energy collision…

Data Analysis, Statistics and Probability · Physics 2020-03-20 S. Chekanov , M. Erickson

Genotype-to-phenotype mappings translate genotypic variations such as mutations into phenotypic changes. Neutrality is the observation that some mutations do not lead to phenotypic changes. Studying the search trajectories in genotypic and…

Populations and Evolution · Quantitative Biology 2023-06-26 Ting Hu , Gabriela Ochoa , Wolfgang Banzhaf

In the drug discovery process, where experiments can be costly and time-consuming, computational models that predict drug-target interactions are valuable tools to accelerate the development of new therapeutic agents. Estimating the…

Machine Learning · Computer Science 2024-07-22 Hannah Rosa Friesacher , Ola Engkvist , Lewis Mervin , Yves Moreau , Adam Arany

Motivation: Gene selection has become a common task in most gene expression studies. The objective of such research is often to identify the smallest possible set of genes that can still achieve good predictive performance. The problem of…

Effectively modeling phenomena present in highly nonlinear dynamical systems whilst also accurately quantifying uncertainty is a challenging task, which often requires problem-specific techniques. We present a novel, domain-agnostic…

Machine Learning · Statistics 2021-10-26 Thomas M. McDonald , Mauricio A. Álvarez

Large language models with a huge number of parameters, when trained on near internet-sized number of tokens, have been empirically shown to obey neural scaling laws: specifically, their performance behaves predictably as a power law in…

Machine Learning · Computer Science 2022-11-01 Alexander Maloney , Daniel A. Roberts , James Sully