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In this work, we propose a model-agnostic instance-based post-hoc explainability method for time series classification. The proposed algorithm, namely Time-CF, leverages shapelets and TimeGAN to provide counterfactual explanations for…

Machine Learning · Computer Science 2024-02-05 Qi Huang , Wei Chen , Thomas Bäck , Niki van Stein

Estimating counterfactual outcomes over time has the potential to unlock personalized healthcare by assisting decision-makers to answer ''what-iF'' questions. Existing causal inference approaches typically consider regular, discrete-time…

Machine Learning · Computer Science 2022-06-17 Nabeel Seedat , Fergus Imrie , Alexis Bellot , Zhaozhi Qian , Mihaela van der Schaar

Precision medicine has the potential to tailor treatment decisions to individual patients using machine learning (ML) and artificial intelligence (AI), but it faces significant challenges due to complex biases in clinical observational data…

Machine Learning · Computer Science 2024-11-26 Michael Vollenweider , Manuel Schürch , Chiara Rohrer , Gabriele Gut , Michael Krauthammer , Andreas Wicki

Reinforcement Learning (RL) has shown great promise in domains like healthcare and robotics but often struggles with adoption due to its lack of interpretability. Counterfactual explanations, which address "what if" scenarios, provide a…

Machine Learning · Computer Science 2025-05-20 Shuyang Dong , Shangtong Zhang , Lu Feng

The treatment effects of medications play a key role in guiding medical prescriptions. They are usually assessed with randomized controlled trials (RCTs), which are expensive. Recently, large-scale electronic health records (EHRs) have…

Machine Learning · Statistics 2019-08-20 Linying Zhang , Yixin Wang , Anna Ostropolets , Jami J. Mulgrave , David M. Blei , George Hripcsak

Response curves exhibit the magnitude of the response of a sensitive system to a varying stimulus. However, response of such systems may be sensitive to multiple stimuli (i.e., input features) that are not necessarily independent. As a…

Machine Learning · Computer Science 2023-04-14 Giorgio Morales , John Sheppard

With the introduction of the Electric Health Records, large amounts of digital data become available for analysis and decision support. When physicians are prescribing treatments to a patient, they need to consider a large range of data…

Machine Learning · Computer Science 2016-12-05 Yinchong Yang , Peter A. Fasching , Markus Wallwiener , Tanja N. Fehm , Sara Y. Brucker , Volker Tresp

Counterfactual explanations (CEs) offer interpretable insights into machine learning predictions by answering ``what if?" questions. However, in real-world settings where models are frequently updated, existing counterfactual explanations…

Machine Learning · Computer Science 2026-02-12 Jamie Duell , Xiuyi Fan

LLMs can be unpredictable, as even slight alterations to the prompt can cause the output to change in unexpected ways. Thus, the ability of models to accurately explain their behavior is critical, especially in high-stakes settings. One…

Computation and Language · Computer Science 2025-11-26 Marvin Limpijankit , Yanda Chen , Melanie Subbiah , Nicholas Deas , Kathleen McKeown

Counterfactual explanations utilize feature perturbations to analyze the outcome of an original decision and recommend an actionable recourse. We argue that it is beneficial to provide several alternative explanations rather than a single…

Machine Learning · Computer Science 2023-01-24 Natraj Raman , Daniele Magazzeni , Sameena Shah

Plausible counterfactual explanations (p-CFEs) are perturbations that minimally modify inputs to change classifier decisions while remaining plausible under the data distribution. In this study, we demonstrate that classifiers can be…

Machine Learning · Computer Science 2025-11-14 Shpresim Sadiku , Kartikeya Chitranshi , Hiroshi Kera , Sebastian Pokutta

A causal falling rule list (CFRL) is a sequence of if-then rules that specifies heterogeneous treatment effects, where (i) the order of rules determines the treatment effect subgroup a subject belongs to, and (ii) the treatment effect…

Artificial Intelligence · Computer Science 2017-07-06 Fulton Wang , Cynthia Rudin

Causal machine learning (ML) offers flexible, data-driven methods for predicting treatment outcomes including efficacy and toxicity, thereby supporting the assessment and safety of drugs. A key benefit of causal ML is that it allows for…

Counterfactual Explanations (CEs) help address the question: How can the factors that influence the prediction of a predictive model be changed to achieve a more favorable outcome from a user's perspective? Thus, they bear the potential to…

Machine Learning · Computer Science 2023-11-27 Xuan Zhao , Klaus Broelemann , Gjergji Kasneci

Counterfactual explanation is an important Explainable AI technique to explain machine learning predictions. Despite being studied actively, existing optimization-based methods often assume that the underlying machine-learning model is…

Artificial Intelligence · Computer Science 2022-06-01 Wenzhuo Yang , Jia Li , Caiming Xiong , Steven C. H. Hoi

Counterfactual explanations promote explainability in machine learning models by answering the question "how should an input instance be perturbed to obtain a desired predicted label?". The comparison of this instance before and after…

Machine Learning · Computer Science 2022-11-09 Jing Ma , Ruocheng Guo , Saumitra Mishra , Aidong Zhang , Jundong Li

Much research has been devoted to the problem of learning fair representations; however, they do not explicitly the relationship between latent representations. In many real-world applications, there may be causal relationships between…

Machine Learning · Computer Science 2023-12-19 Ziqi Xu , Jixue Liu , Debo Cheng , Jiuyong Li , Lin Liu , Ke Wang

Estimating an individual's potential outcomes under counterfactual treatments is a challenging task for traditional causal inference and supervised learning approaches when the outcome is high-dimensional (e.g. gene expressions, impulse…

Machine Learning · Statistics 2025-02-13 Yulun Wu , Layne C. Price , Zichen Wang , Vassilis N. Ioannidis , Robert A. Barton , George Karypis

Dynamic prediction of causal effects under different treatment regimes conditional on an individual's characteristics and longitudinal history is an essential problem in precision medicine. This is challenging in practice because outcomes…

Methodology · Statistics 2023-03-07 Yizhen Xu , Jisoo Kim , Laura K. Hummers , Ami A. Shah , Scott Zeger

Computational fluid dynamics (CFD) can be used to simulate vascular haemodynamics and analyse potential treatment options. CFD has shown to be beneficial in improving patient outcomes. However, the implementation of CFD for routine clinical…