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Reliably predicting the products of chemical reactions presents a fundamental challenge in synthetic chemistry. Existing machine learning approaches typically produce a reaction product by sequentially forming its subparts or intermediate…

Chemical Physics · Physics 2021-06-16 Hangrui Bi , Hengyi Wang , Chence Shi , Connor Coley , Jian Tang , Hongyu Guo

Reaction prediction is a fundamental problem in computational chemistry. Existing approaches typically generate a chemical reaction by sampling tokens or graph edits sequentially, conditioning on previously generated outputs. These…

Chemical Physics · Physics 2021-02-08 Hangrui Bi , Hengyi Wang , Chence Shi , Jian Tang

While self-attention has been instrumental in the success of Transformers, it can lead to over-concentration on a few tokens during training, resulting in suboptimal information flow. Enforcing doubly-stochastic constraints in attention…

Machine Learning · Computer Science 2025-07-15 Ashkan Shahbazi , Elaheh Akbari , Darian Salehi , Xinran Liu , Navid Naderializadeh , Soheil Kolouri

The self-attention mechanism is central to the success of Transformer architectures. However, standard row-stochastic attention has been shown to suffer from significant signal degradation across layers. In particular, it can induce rank…

Machine Learning · Computer Science 2026-04-10 Michela Lapenna , Rita Fioresi , Bahman Gharesifard

Central to our understanding of chemical reactivity is the principle of mass conservation, which is fundamental for ensuring physical consistency, balancing equations, and guiding reaction design. However, data-driven computational models…

Machine Learning · Computer Science 2025-02-19 Joonyoung F. Joung , Mun Hong Fong , Nicholas Casetti , Jordan P. Liles , Ne S. Dassanayake , Connor W. Coley

The stochastic reaction network in which chemical species evolve through a set of reactions is widely used to model stochastic processes in physics, chemistry and biology. To characterize the evolving joint probability distribution in the…

Molecular Networks · Quantitative Biology 2023-02-08 Ying Tang , Jiayu Weng , Pan Zhang

In this article we consider one-dimensional random systems of hyperbolic conservation laws. We first establish existence and uniqueness of random entropy admissible solutions for initial value problems of conservation laws which involve…

Numerical Analysis · Mathematics 2020-03-16 Jan Giesselmann , Fabian Meyer , Christian Rohde

Attention based models such as Transformers involve pairwise interactions between data points, modeled with a learnable attention matrix. Importantly, this attention matrix is normalized with the SoftMax operator, which makes it row-wise…

Machine Learning · Computer Science 2022-01-25 Michael E. Sander , Pierre Ablin , Mathieu Blondel , Gabriel Peyré

The classical models for irreversible diffusion-influenced reactions can be derived by introducing absorbing boundary conditions to over-damped continuous Brownian motion (BM) theory. As there is a clear corresponding stochastic process,…

Statistical Mechanics · Physics 2016-10-13 Mauricio J. Del Razo , Hong Qian

We formulate an attention mechanism for continuous and ordered sequences that explicitly functions as an alignment model, which serves as the core of many sequence-to-sequence tasks. Standard scaled dot-product attention relies on…

Machine Learning · Computer Science 2025-09-19 Hyungjoon Soh , Junghyo Jo

Autoregressive models (ARMs) have become the workhorse for sequence generation tasks, since many problems can be modeled as next-token prediction. While there appears to be a natural ordering for text (i.e., left-to-right), for many data…

Machine Learning · Computer Science 2025-07-15 Zhe Wang , Jiaxin Shi , Nicolas Heess , Arthur Gretton , Michalis K. Titsias

Reinforcement learning algorithms rely on exploration to discover new behaviors, which is typically achieved by following a stochastic policy. In continuous control tasks, policies with a Gaussian distribution have been widely adopted.…

Machine Learning · Computer Science 2019-03-28 Dmytro Korenkevych , A. Rupam Mahmood , Gautham Vasan , James Bergstra

Retrosynthesis prediction is one of the fundamental challenges in organic chemistry and related fields. The goal is to find reactants molecules that can synthesize product molecules. To solve this task, we propose a new graph-to-graph…

Quantitative Methods · Quantitative Biology 2022-04-20 Zaiyun Lin , Shiqiu Yin , Lei Shi , Wenbiao Zhou , YingSheng Zhang

It is fundamental for science and technology to be able to predict chemical reactions and their properties. To achieve such skills, it is important to develop good representations of chemical reactions, or good deep learning architectures…

Machine Learning · Computer Science 2022-01-05 Mohammadamin Tavakoli , Alexander Shmakov , Francesco Ceccarelli , Pierre Baldi

The neural attention mechanism has been incorporated into deep neural networks to achieve state-of-the-art performance in various domains. Most such models use multi-head self-attention which is appealing for the ability to attend to…

Machine Learning · Computer Science 2021-10-26 Shujian Zhang , Xinjie Fan , Huangjie Zheng , Korawat Tanwisuth , Mingyuan Zhou

Reaction prediction, a critical task in synthetic chemistry, is to predict the outcome of a reaction based on given reactants. Generative models like Transformer have typically been employed to predict the reaction product. However, these…

Machine Learning · Computer Science 2025-11-13 Taicheng Guo , Changsheng Ma , Xiuying Chen , Bozhao Nan , Kehan Guo , Shichao Pei , Nitesh V. Chawla , Olaf Wiest , Xiangliang Zhang

Distributionally robust optimization (DRO) is a powerful technique to train robust models against data distribution shift. This paper aims to solve regularized nonconvex DRO problems, where the uncertainty set is modeled by a so-called…

Optimization and Control · Mathematics 2025-06-30 Yufeng Yang , Yi Zhou , Zhaosong Lu

Information asymmetry between the Distribution System Operator (DSO) and Distributed Energy Resource Aggregators (DERAs) obstructs designing effective incentives for voltage regulation. To capture this effect, we employ a Stackelberg…

Systems and Control · Electrical Eng. & Systems 2024-08-07 Zhirui Liang , Qi Li , Joshua Comden , Andrey Bernstein , Yury Dvorkin

Doubly-stochastic attention has emerged as a transport-based alternative to row-softmax attention, with recent Transformer variants using it to reduce attention sinks and rank collapse while improving performance. In this family, the…

Machine Learning · Computer Science 2026-05-14 Huy Tran , Max Milkert , David Hyde

The ability to accurately predict human behavior is central to the safety and efficiency of robot autonomy in interactive settings. Unfortunately, robots often lack access to key information on which these predictions may hinge, such as…

Robotics · Computer Science 2022-06-07 Haimin Hu , Jaime F. Fisac
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