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High stakes decision-making often requires a continuous interplay between evolving evidence and shifting hypotheses, a dynamic that is not well supported by current AI decision support systems. In this paper, we introduce a mixed-initiative…

Human-Computer Interaction · Computer Science 2025-04-23 Chengbo Zheng , Tim Miller , Alina Bialkowski , H Peter Soyer , Monika Janda

This study introduces a novel and accurate approach to breast cancer classification using histopathology images. It systematically compares leading Convolutional Neural Network (CNN) models across varying image datasets, identifies their…

Computer Vision and Pattern Recognition · Computer Science 2024-10-07 Gary Murphy , Raghubir Singh

Statistical models for describing the probability distribution over the states of biological systems are commonly used for dimensional reduction. Among these models, pairwise models are very attractive in part because they can be fit using…

Quantitative Methods · Quantitative Biology 2009-11-30 Yasser Roudi , Erik Aurell , John Hertz

Commonly, AI or machine learning (ML) models are evaluated on benchmark datasets. This practice supports innovative methodological research, but benchmark performance can be poorly correlated with performance in real-world applications -- a…

Machine Learning · Computer Science 2024-06-18 Olivier Binette , Jerome P. Reiter

Several machine learning techniques for accurate detection of skin cancer from medical images have been reported. Many of these techniques are based on pre-trained convolutional neural networks (CNNs), which enable training the models based…

Computer Vision and Pattern Recognition · Computer Science 2021-05-18 Aqsa Saeed Qureshi , Teemu Roos

Histopathological analysis is the present gold standard for precancerous lesion diagnosis. The goal of automated histopathological classification from digital images requires supervised training, which requires a large number of expert…

Image and Video Processing · Electrical Eng. & Systems 2021-11-15 Yuan Xue , Jiarong Ye , Qianying Zhou , Rodney Long , Sameer Antani , Zhiyun Xue , Carl Cornwell , Richard Zaino , Keith Cheng , Xiaolei Huang

Cell detection and segmentation are integral parts of automated systems in digital pathology. Encoder-decoder networks have emerged as a promising solution for these tasks. However, training of these networks has typically required full…

The histological assessment of human tissue has emerged as the key challenge for detection and treatment of cancer. A plethora of different data sources ranging from tissue microarray data to gene expression, proteomics or metabolomics data…

Computer Vision and Pattern Recognition · Computer Science 2016-01-05 Thomas J. Fuchs , Joachim M. Buhmann

Melanoma represents a critical health risk due to its aggressive progression and high mortality, underscoring the need for early, interpretable diagnostic tools. While deep learning has advanced in skin lesion classification, most existing…

Computer Vision and Pattern Recognition · Computer Science 2025-07-28 Ciro Listone , Aniello Murano

With the development of natural language processing techniques(NLP), automatic diagnosis of eye diseases using ophthalmology electronic medical records (OEMR) has become possible. It aims to evaluate the condition of both eyes of a patient…

Computation and Language · Computer Science 2023-01-12 Xu Ye , Meng Xiao , Zhiyuan Ning , Weiwei Dai , Wenjuan Cui , Yi Du , Yuanchun Zhou

The quantification of biomarkers on immunohistochemistry breast cancer images is essential for defining appropriate therapy for breast cancer patients, as well as for extracting relevant information on disease prognosis. This is an arduous…

Image and Video Processing · Electrical Eng. & Systems 2023-11-27 Blanca Maria Priego-Torresa , Barbara Lobato-Delgado , Lidia Atienza-Cuevas , Daniel Sanchez-Morillo

Pathology image analysis plays a pivotal role in medical diagnosis, with deep learning techniques significantly advancing diagnostic accuracy and research. While numerous studies have been conducted to address specific pathological tasks,…

Image and Video Processing · Electrical Eng. & Systems 2025-03-31 Dankai Liao , Sicheng Chen , Nuwa Xi , Qiaochu Xue , Jieyu Li , Lingxuan Hou , Zeyu Liu , Chang Han Low , Yufeng Wu , Yiling Liu , Yanqin Jiang , Dandan Li , Shangqing Lyu

An automated method to detect and analyze the melanoma is presented to improve diagnosis which will leads to the exact treatment. Image processing techniques such as segmentation, feature descriptors and classification models are involved…

Computer Vision and Pattern Recognition · Computer Science 2017-03-02 G Wiselin Jiji , P Johnson Durai Raj

We introduce a comprehensive framework for modeling single cell transcriptomic responses to perturbations, aimed at standardizing benchmarking in this rapidly evolving field. Our approach includes a modular and user-friendly model…

Recent breakthroughs in self-supervised learning have enabled the use of large unlabeled datasets to train visual foundation models that can generalize to a variety of downstream tasks. While this training paradigm is well suited for the…

Language model benchmarks are pervasive and computationally-efficient proxies for real-world performance. However, many recent works find that benchmarks often fail to predict real utility. Towards bridging this gap, we introduce benchmark…

Artificial Intelligence · Computer Science 2026-05-28 Marco Gutierrez , Xinyi Leng , Hannah Cyberey , Jonathan Richard Schwarz , Ahmed Alaa , Thomas Hartvigsen

Bayesian inference involves two main computational challenges. First, in estimating the parameters of some model for the data, the posterior distribution may well be highly multi-modal: a regime in which the convergence to stationarity of…

Instrumentation and Methods for Astrophysics · Physics 2019-12-10 F. Feroz , M. P. Hobson , E. Cameron , A. N. Pettitt

Foundation models have emerged as a powerful paradigm in computational pathology (CPath), enabling scalable and generalizable analysis of histopathological images. While early developments centered on uni-modal models trained solely on…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Xiaohui Chen , Yi He , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

Video frame interpolation, the task of synthesizing new frames in between two or more given ones, is becoming an increasingly popular research target. However, the current evaluation of frame interpolation techniques is not ideal. Due to…

Computer Vision and Pattern Recognition · Computer Science 2024-03-27 Simon Kiefhaber , Simon Niklaus , Feng Liu , Simone Schaub-Meyer

Assessing image quality is crucial in image processing tasks such as compression, super-resolution, and denoising. While subjective assessments involving human evaluators provide the most accurate quality scores, they are impractical for…

Multimedia · Computer Science 2025-03-26 Shima Mohammadi , João Ascenso