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Biophysical models of diffusion in white matter are based on what is now commonly referred to as the "Standard Model" (SM) of non-exchanging anisotropic Gaussian compartments. In this work, we focus on diffusion MRI in gray matter, which…

Purpose: Double diffusion encoding (DDE) MRI enables the estimation of microscopic diffusion anisotropy, yielding valuable information on tissue microstructure. A recent study proposed that the acquisition of rotationally invariant DDE…

Medical Physics · Physics 2019-11-05 Leevi Kerkelä , Rafael Neto Henriques , Matt G. Hall , Chris A. Clark , Noam Shemesh

Biophysical models in diffusion MRI (dMRI) hold promise for characterizing gray matter tissue microstructure. Yet, the reliability of their parameter estimates remains largely under-studied, especially in models that incorporate water…

Magnetic Resonance cardiac diffusion tensor imaging (cDTI) and cardiac intravoxel incoherent motion imaging enables probing of in vivo myofiber architecture and myocardial perfusion surrogates. To study the impact of experimental parameters…

Diffusion MRI (dMRI) is a unique imaging technique for in vivo characterization of tissue microstructure and white matter pathways. However, its relatively long acquisition time implies greater motion artifacts when imaging, for example,…

Medical Physics · Physics 2020-02-26 Yoonmi Hong , Wei-Tang Chang , Geng Chen , Ye Wu , Weili Lin , Dinggang Shen , Pew-Thian Yap

Magnetic resonance diffusion tensor imaging (DTI) is a critical tool for neural disease diagnosis. However, long scan time greatly hinders the widespread clinical use of DTI. To accelerate image acquisition, a feature-enhanced joint…

Image and Video Processing · Electrical Eng. & Systems 2024-05-28 Lang Zhang , Jinling He , Dong Liang , Hairong Zheng , Yanjie Zhu

We develop a flexible framework for modeling high-dimensional imaging data observed longitudinally. The approach decomposes the observed variability of repeatedly measured high-dimensional observations into three additive components: a…

This paper investigates the impact of cell body (soma) size and branching of cellular projections on diffusion MR imaging (dMRI) and spectroscopy (dMRS) signals for both standard single diffusion encoding (SDE) and more advanced double…

Medical Physics · Physics 2021-07-26 Andrada Ianus , Daniel C. Alexander , Hui Zhang , Marco Palombo

Monitoring time-dependence with diffusion MRI yields observables sensitive to compartment sizes (restricted diffusion) and membrane permeability (water exchange). However, restricted diffusion and exchange have opposite effects on the…

Diffusion Magnetic Resonance Imaging (dMRI) plays a critical role in studying microstructural changes in the brain. It is, therefore, widely used in clinical practice; yet progress in learning general-purpose representations from dMRI has…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Gustavo Chau Loo Kung , Mohammad Abbasi , Camila Blank , Juze Zhang , Alan Q. Wang , Sophie Ostmeier , Akshay Chaudhari , Kilian Pohl , Ehsan Adeli

In vivo cardiac diffusion tensor imaging (cDTI) is a promising Magnetic Resonance Imaging (MRI) technique for evaluating the micro-structure of myocardial tissue in the living heart, providing insights into cardiac function and enabling the…

In diffusion-based communication, as for molecular systems, the achievable data rate is low due to the stochastic nature of diffusion which exhibits a severe inter-symbol-interference (ISI). Multiple-Input Multiple-Output (MIMO)…

Information Theory · Computer Science 2019-04-26 S. M. Reza Rouzegar , Umberto Spagnolini

Diffusion MRI (dMRI) is essential for studying brain microstructure, but high-resolution imaging remains challenging due to the inherent trade-offs between acquisition time and signal-to-noise ratio (SNR). Conventional methods often…

Image and Video Processing · Electrical Eng. & Systems 2025-05-20 Yinzhe Wu , Jiahao Huang , Fanwen Wang , Mengze Gao , Congyu Liao , Guang Yang , Kawin Setsompop

The K\"arger model and its derivatives have been widely used to incorporate transcytolemmal water exchange rate, an essential characteristic of living cells, into analyses of diffusion MRI (dMRI) signals from tissues. The K\"arger model…

Medical Physics · Physics 2024-11-08 Diwei Shi , Fan Liu , Sisi Li , Li Chen , Xiaoyu Jiang , John C. Gore , Quanshui Zheng , Hua Guo , Junzhong Xu

Purpose: Eddy currents might lead to image distortions in diffusion weighted echo planar imaging. A method is proposed to reduce their effects on double diffusion encoding (DDE) MRI experiments and the thereby derived microscopic fractional…

Medical Physics · Physics 2021-04-20 Lars Mueller , Andreas Wetscherek , Tristan Anselm Kuder , Frederik Bernd Laun

Diffusion MRI (dMRI) provides contrast that reflect diffusing spins' interactions with microstructural features of biological systems, but its specificity remains limited due to the ambiguity of its relation to the underlying…

Medical Physics · Physics 2022-03-29 Jonas L. Olesen , Leif Østergaard , Noam Shemesh , Sune N. Jespersen

The dependence of the diffusion MRI signal on the diffusion time carries signatures of restricted diffusion and exchange. Here we seek to highlight these signatures in the human brain by performing experiments using free gradient waveforms…

Diffusion exchange spectroscopy (DEXSY) is a method to probe exchange between domains of varying confinement. Analyses of DEXSY signals typically assume Gaussian diffusion within distinct compartments and first-order exchange kinetics…

Materials Science · Physics 2026-03-31 Teddy X Cai , Nathan H Williamson , Peter J Basser

Monocular Depth Estimation (MDE) is a fundamental computer vision task with important applications in 3D vision. The current mainstream MDE methods employ an encoder-decoder architecture with multi-level/scale feature processing. However,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Huibin Bai , Shuai Li , Hanxiao Zhai , Yanbo Gao , Chong Lv , Yibo Wang , Haipeng Ping , Wei Hua , Xingyu Gao

Microscopic diffusion anisotropy ({\mu}A) has been recently gaining increasing attention for its ability to decouple the average compartment anisotropy from orientation dispersion. Advanced diffusion MRI sequences, such as double diffusion…