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Many existing models for clinical trial outcome prediction are optimized using task-specific loss functions on trial phase-specific data. While this scheme may boost prediction for common diseases and drugs, it can hinder learning of…

Machine Learning · Computer Science 2025-05-27 Yiqing Zhang , Xiaozhong Liu , Fabricio Murai

Nowadays, the screening methods for the early detection of lung cancer struggle with several limitations such as many false positive results and low sensitivity. The detection of specific biomarkers is of high interest to complement these…

Quantitative Methods · Quantitative Biology 2021-02-19 Juul Goossens , Jente Gieghase , Elien Derveaux , Peter Adriaensens

Tumor heterogeneity is a challenge to designing effective and targeted therapies. Glioma-type identification depends on specific molecular and histological features, which are defined by the official WHO classification CNS. These guidelines…

Applications · Statistics 2023-05-23 Roberta Coletti , Mónica L. Mendonça , Susana Vinga , Marta B. Lopes

Breast cancer (BC) remains a significant global health challenge, with personalized treatment selection complicated by the disease's molecular and clinical heterogeneity. BC treatment decisions rely on various patient-specific clinical…

Applications · Statistics 2025-07-10 Md Nahid Hasan , Md Monzur Murshed , Md Mahadi Hasan , Faysal A. Chowdhury

Linear mixed models (LMM) are widely adopted in genome-wide association studies (GWAS) to account for population stratification and cryptic relatedness. However, the parameter estimation of LMMs imposes substantial computational burdens due…

Computation · Statistics 2025-08-08 Zhibin Pu , Shufei Ge , Shijia Wang

The Gromov-Wasserstein (GW) variant of optimal transport, designed to compare probability densities defined over distinct metric spaces, has emerged as an important tool for the analysis of data with complex structure, such as ensembles of…

Machine Learning · Statistics 2025-08-15 Mary Chriselda Antony Oliver , Emmanuel Hartman , Tom Needham

Most recently, the pathology diagnosis of cancer is shifting to integrating molecular makers with histology features. It is a urgent need for digital pathology methods to effectively integrate molecular markers with histology, which could…

Image and Video Processing · Electrical Eng. & Systems 2023-06-28 Xiaofei Wang , Stephen Price , Chao Li

With the advancement of high-throughput biotechnologies, we increasingly accumulate biomedical data about diseases, especially cancer. There is a need for computational models and methods to sift through, integrate, and extract new…

Quantitative Methods · Quantitative Biology 2020-07-03 Thomas Gaudelet , Noel Malod-Dognin , Natasa Przulj

The use of diverse modalities, such as omics, medical images, and clinical data can not only improve the performance of prognostic models but also deepen an understanding of disease mechanisms and facilitate the development of novel…

Image and Video Processing · Electrical Eng. & Systems 2025-08-14 Maria Boyko , Aleksandra Beliaeva , Dmitriy Kornilov , Alexander Bernstein , Maxim Sharaev

We consider joint beamforming and stream allocation to maximize the weighted sum rate (WSR) for non-coherent joint transmission (NCJT) in user-centric cell-free MIMO networks, where distributed access points (APs) are organized in clusters…

Signal Processing · Electrical Eng. & Systems 2024-02-29 Xi Wang , Xiaotong Zhao , Juncheng Wang , You Li , Qingjiang Shi

Local feature matching is an essential component in many visual applications. In this work, we propose OAMatcher, a Tranformer-based detector-free method that imitates humans behavior to generate dense and accurate matches. Firstly,…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Kun Dai , Tao Xie , Ke Wang , Zhiqiang Jiang , Ruifeng Li , Lijun Zhao

Survival prediction is a complicated ordinal regression task that aims to predict the ranking risk of death, which generally benefits from the integration of histology and genomic data. Despite the progress in joint learning from pathology…

Computer Vision and Pattern Recognition · Computer Science 2023-09-12 Yingxue Xu , Hao Chen

In clinical practice, there is significant interest in integrating novel biomarkers with existing clinical data to construct interpretable and robust decision rules. Motivated by the need to improve decision-making for early disease…

Methodology · Statistics 2026-02-23 Albert Osom , Camden Lopez , Ashley Alexander , Suresh Chari , Ziding Feng , Ying-Qi Zhao

Purpose: We aimed to develop a data-driven multiomics approach integrating radiomics, dosiomics, and delta features to predict treatment response at an earlier stage (intra-treatment) for brain metastases (BMs) patients treated with PULSAR.…

High-resolution radar sensors are critical for autonomous systems but pose significant challenges to traditional tracking algorithms due to the generation of multiple measurements per object and the presence of multipath effects. Existing…

Signal Processing · Electrical Eng. & Systems 2026-03-10 Guanhua Ding , Qinchen Wu , Jinping Sun , Yanping Wang , Bing Zhu , Guoqiang Mao

This paper introduces the use of unbalanced optimal transport methods as a similarity measure for diffeomorphic matching of imaging data. The similarity measure is a key object in diffeomorphic registration methods that, together with the…

Numerical Analysis · Mathematics 2017-06-19 Jean Feydy , Benjamin Charlier , François-Xavier Vialard , Gabriel Peyré

It was shown recently that CSMA (Carrier Sense Multiple Access)-like distributed algorithms can achieve the maximal throughput in wireless networks (and task processing networks) under certain assumptions. One important, but idealized…

Networking and Internet Architecture · Computer Science 2016-11-18 Libin Jiang , Jean Walrand

We introduce a new framework for efficient sampling from complex probability distributions, using a combination of optimal transport maps and the Metropolis-Hastings rule. The core idea is to use continuous transportation to transform…

Computation · Statistics 2019-06-11 Matthew Parno , Youssef Marzouk

Medical decision-making requires integrating diverse medical information, from imaging to clinical narratives. These medical modalities are often acquired in a many-to-many manner. However, current medical vision-language pretraining models…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Yuan Gao , Sangwook Kim , Jianzhong You , Chris McIntosh