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Evolutionary dynamics is often viewed as a subtle process of change accumulation that causes a divergence among organisms and their genomes. However, this interpretation is an inheritance of a gradualistic view that has been challenged at…

Populations and Evolution · Quantitative Biology 2018-07-27 Jacobo Aguirre , Pablo Catalán , José A. Cuesta , Susanna Manrubia

Biological systems encode function not primarily in steady states, but in the structure of transient responses elicited by time-varying stimuli. Overshoots, biphasic dynamics, adaptation kinetics, fold-change detection, entrainment, and…

Quantitative Methods · Quantitative Biology 2026-01-05 Eduardo D. Sontag

Adaptive network dynamical systems describe the co-evolution of dynamical quantities on the nodes as well as dynamics of the network connections themselves. For dense networks of many nodes, the resulting dynamics are typically…

Adaptation and Self-Organizing Systems · Physics 2025-09-18 Erik Andreas Martens , Christian Bick

In this work, we investigate a model of an adaptive networked dynamical system, where the coupling strengths among phase oscillators coevolve with the phase states. It is shown that in this model the oscillators can spontaneously…

Disordered Systems and Neural Networks · Physics 2010-11-02 Menghui Li , Shuguang Guan , C. -H. Lai

Complex dynamical systems are often modeled as networks, with nodes representing dynamical units which interact through the network's links. Gene regulatory networks, responsible for the production of proteins inside a cell, are an example…

Statistical Mechanics · Physics 2009-09-30 Zoran Levnajić

We show that a neural network originally designed for language processing can learn the dynamical rules of a stochastic system by observation of a single dynamical trajectory of the system, and can accurately predict its emergent behavior…

Statistical Mechanics · Physics 2022-02-18 Corneel Casert , Isaac Tamblyn , Stephen Whitelam

Dynamical systems can autonomously adapt their organization so that the required target dynamics is reproduced. In the previous Rapid Communication [Phys. Rev. E 90,030901(R) (2014)], it was shown how such systems can be designed using…

Adaptation and Self-Organizing Systems · Physics 2016-11-04 Pablo Kaluza , Alexander S. Mikhailov

A macroscopic theory for describing cellular states during steady-growth is presented, which is based on the consistency between cellular growth and molecular replication, as well as the robustness of phenotypes against perturbations.…

Populations and Evolution · Quantitative Biology 2021-02-08 Kunihiko Kaneko , Chikara Furusawa

We study a genetic regulatory network model developed to demonstrate that genetic robustness can evolve through stabilizing selection for optimal phenotypes. We report preliminary results on whether such selection could result in a…

Molecular Networks · Quantitative Biology 2010-12-07 Volkan Sevim , Per Arne Rikvold

We study the multiscale structure of the Jain-Krishna adaptive network model. This model describes the co-evolution of a set of continuous-time autocatalytic ordinary differential equations and its underlying discrete-time graph structure.…

Dynamical Systems · Mathematics 2019-03-04 Christian Kuehn

Living systems adapt to various environmental conditions by changing their internal states. Inspired by gene expression and epigenetic modification dynamics, we herein propose a generic mechanism for adaptation by combining fast oscillatory…

Quantitative Methods · Quantitative Biology 2022-09-23 Yuuki Matsushita , Kunihiko Kaneko

The basic mechanics of evolution have been understood since Darwin. But debate continues over whether macroevolutionary phenomena are driven primary by the fitness structure of genotype space or by ecological interaction. In this paper we…

Populations and Evolution · Quantitative Biology 2012-10-22 David V. Foster , Mary M. Rorick , Tanja Gesell , Laura Feeney , Jacob G. Foster

Biological functions are generated as a result of developmental dynamics that form phenotypes governed by genotypes. The dynamical system for development is shaped through genetic evolution following natural selection based on the fitness…

Populations and Evolution · Quantitative Biology 2009-11-13 Kunihiko Kaneko

We analyze a nonlocal PDE model describing the dynamics of adaptation of a phenotypically structured population, under the effects of mutation and selection, in a changing environment. Previous studies have analyzed the large-time behavior…

Analysis of PDEs · Mathematics 2020-09-25 Lionel Roques , Florian Patout , Olivier Bonnefon , Guillaume Martin

Self-adaptive dynamics occurs in many physical systems such as socio-economics, neuroscience, or biophysics. We formalize a self-adaptive modeling approach, where adaptation takes place within a set of strategies based on the history of the…

Adaptation and Self-Organizing Systems · Physics 2022-04-01 Konstantin Clauß , Christian Kuehn

We present a model of adaptive regulatory networks consisting of a simple biologically-motivated rewiring procedure coupled to an elementary stability criterion. The resulting networks exhibit a characteristic stationary heavy-tailed degree…

Physics and Society · Physics 2020-08-05 Ben D. MacArthur , Rubén J. Sánchez-García , Avi Ma'ayan

Biological systems must be robust for stable function against perturbations, but robustness alone is not sufficient. The ability to switch between appropriate states (phenotypes) in response to different conditions is essential for…

Populations and Evolution · Quantitative Biology 2023-04-25 Ayaka Sakata , Kunihiko Kaneko

Multi-agent systems often operate under feedback, adaptation, and non-stationarity, yet many simulation studies retain static decision rules and fixed control parameters. This paper introduces a general adaptive multi-agent learning…

Multiagent Systems · Computer Science 2025-11-26 Roberto Garrone

Understanding how gene regulatory networks (GRNs) give rise to stable and dynamic cellular states remains a central challenge in theoretical biology, particularly when slow epigenetic feedback reshapes the underlying regulatory landscape.…

Molecular Networks · Quantitative Biology 2026-04-15 Sascha H. Hauck , Sandip Saha , Narsis A. Kiani , Jesper N. Tegner

We study the evolution of artificial learning systems by means of selection. Genetic programming is used to generate a sequence of populations of algorithms which can be used by neural networks for supervised learning of a rule that…

Biological Physics · Physics 2009-11-07 Juan Pablo Neirotti , Nestor Caticha
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