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Noncontact label-free biomechanical imaging is a crucial tool for unraveling the mechanical properties of biological systems, which play critical roles in the fields of engineering, physics, biology and medicine; yet, it represents a…

Biological Physics · Physics 2020-09-29 Itay Remer , Netta Shemsesh , Anat Ben-Zvi , Alberto Bilenca

The biomechanical properties of cells and tissues play an important role in our fundamental understanding of the structures and functions of biological systems at both the cellular and subcellular levels. Recently, Brillouin microscopy,…

Brillouin microscopy is an emerging optical elastography technique that can be used to assess mechanical properties of biological samples in a 3D, all-optical and hence non-contact fashion. However, the low cross-section of spontaneous…

Optics · Physics 2024-09-04 Carlo Bevilacqua , Robert Prevedel

Brillouin microscopy is an emerging technique for all-optical biomechanical imaging without the need for physical contact with the sample or for an external mechanical stimulus. However, Brillouin microscopy often retrieves a single,…

Optics · Physics 2024-02-27 Roni Shaashoua , Tal Levy , Barak Rotblat , Alberto Bilenca

Mass density is a vital property for improved biophysical understanding of and within biological samples. It is increasingly attracting active investigation, but still lacks reliable, non-contact techniques to accurately characterize it in…

Soft Condensed Matter · Physics 2025-08-12 Conrad Möckel , Jiarui Li , Giulia Zanini , Jochen Guck , Giuliano Scarcelli

Brillouin spectroscopy and imaging are emerging techniques in analytical science, biophotonics and biomedicine. They are based on Brillouin light scattering from acoustic waves or phonons in the GHz range, providing a nondestructive…

Biological Physics · Physics 2021-10-12 Francesca Palombo , Daniele Fioretto

Brillouin and Raman scattering spectroscopy are established techniques for the nondestructive contactless and label-free readout of mechanical, chemical and structural properties of condensed matter. Brillouin-Raman investigations currently…

Stimulated Brillouin scattering (SBS) microscopy enables label-free biomechanical imaging, with Brillouin gain serving as a critical contrast parameter for quantitative analysis. However, the influence of sample-induced refractive index…

Optics · Physics 2026-04-03 Meng Xu , Zixuan Du , Yun Qi , Jinrui Zhang , Shuai Yao , Robert Prevedel , Fan Yang

Frequency- and time-domain Brillouin scattering spectroscopy are powerful tools to read out the mechanical properties of complex systems in material and life sciences. Indeed, coherent acoustic phonons in the time-domain method offer…

Optics · Physics 2023-01-06 Ayumu Ishijima , Shinga Okabe , Ichiro Sakuma , Keiichi Nakagawa

Brillouin microscopy, which maps elastic modulus from the frequency shift of scattered light, has evolved to a faster speed for the investigation of rapid biomechanical changes. Impulsive stimulated Brillouin scattering (ISBS) spectroscopy…

Optics · Physics 2023-12-07 Jiarui Li , Taoran Le , Hongyuan Zhang , Haoyun Wei , Yan Li

Brillouin imaging is an emerging optical elastography technique able to generate maps of the mechanical properties at microscale, with great potential in biophysical and biomedical fields. A key parameter is its spatial resolution, which is…

Optics · Physics 2020-02-28 Silvia Caponi , Daniele Fioretto , Maurizio Mattarelli

The role and importance of mechanical properties of cells and tissues in cellular function, development as well as disease has widely been acknowledged, however standard techniques currently used to assess them exhibit intrinsic…

Biological Physics · Physics 2019-01-09 Robert Prevedel , Alba Diz-Muñoz , Giancarlo Ruocco , Giuseppe Antonacci

The notion that Stimulated Brillouin Scattering (SBS) is primarily defined by bulk material properties has been overturned by recent work on nanoscale waveguides. It is now understood that boundary forces of radiation pressure and…

Optics · Physics 2015-10-21 Nathan Dostart , Seunghwi Kim , Gaurav Bahl

Brillouin spectroscopy is a century-old technique that has recently received renewed interest, as modern instrumentation has transformed it into a powerful contactless and label-free probe of micromechanical properties for biomedical…

Instrumentation and Detectors · Physics 2020-05-27 YuChen Xiang , Carin Basirun , Joshua Chou , Majid E. Warkiani , Peter Török , Yingying Wang , Shoufei Gao , Irina V. Kabakova

Confocal Brillouin microscopy enables high-resolution mechanical imaging but has low acquisition speed, partly due to its pixel-by-pixel mapping strategy. Line-scanning Brillouin microscopy (LSBM) significantly improves imaging speed by…

Optics · Physics 2026-04-21 Chenjun Shi , Jitao Zhang

Time-domain Brillouin scattering is an opto-acousto-optical probe technique for the evaluation of the transparent materials. Ultrashort pump laser pulses via optoacoustic conversion launch in the sample picosecond coherent acoustic pulses.…

Applied Physics · Physics 2020-06-15 Vitalyi E. Gusev

Stimulated Brillouin scattering (SBS) offers among the highest nonlinear gains in solid materials and has demonstrated advanced photonics functionalities in waveguides. The large compressibility of gases suggests that SBS may gain in…

Optics · Physics 2020-12-22 Fan Yang , Flavien Gyger , Luc Thévenaz

Stimulated Brillouin interaction between sound and light, known to be the strongest optical nonlinearity common to all amorphous and crystalline dielectrics, has been widely studied in fibers and bulk materials but rarely in optical…

Optics · Physics 2011-09-13 Gaurav Bahl , John Zehnpfennig , Matthew Tomes , Tal Carmon

Stimulated Brillouin scattering (SBS) is a very fundamental interaction between light and travelling acoustic waves, which is mainly attributed to the electrostriction and photoelastic effects with the interaction strength being orders of…

Optics · Physics 2015-06-22 Chun-Hua Dong , Zhen Shen , Chang-Ling Zou , Yan-Lei Zhang , Wei Fu , Guang-Can Guo
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