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Deep learning methods have contributed substantially to the rapid advancement of medical image segmentation, the quality of which relies on the suitable design of loss functions. Popular loss functions, including the cross-entropy and dice…

Image and Video Processing · Electrical Eng. & Systems 2022-11-07 Yucong Lin , Jinhua Su , Yuhang Li , Yuhao Wei , Hanchao Yan , Saining Zhang , Jiaan Luo , Danni Ai , Hong Song , Jingfan Fan , Tianyu Fu , Deqiang Xiao , Feifei Wang , Jue Hou , Jian Yang

This paper presents a study on the soft-Dice loss, one of the most popular loss functions in medical image segmentation, for situations where noise is present in target labels. In particular, the set of optimal solutions are characterized…

Computer Vision and Pattern Recognition · Computer Science 2023-05-05 Marcus Nordström , Henrik Hult , Atsuto Maki , Fredrik Löfman

Object segmentation plays an important role in the modern medical image analysis, which benefits clinical study, disease diagnosis, and surgery planning. Given the various modalities of medical images, the automated or semi-automated…

Image and Video Processing · Electrical Eng. & Systems 2020-06-01 Dong Yang , Holger Roth , Xiaosong Wang , Ziyue Xu , Andriy Myronenko , Daguang Xu

Image segmentation is critically important in almost all medical image analysis for automatic interpretations and processing. However, it is often challenging to perform image segmentation due to data imbalance between intra- and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Zhhengyong Huang , Yao Sui

Despite the success of deep learning methods in medical image segmentation tasks, the human-level performance relies on massive training data with high-quality annotations, which are expensive and time-consuming to collect. The fact is that…

Computer Vision and Pattern Recognition · Computer Science 2021-06-22 Jialin Shi , Ji Wu

Large annotated datasets inevitably contain noisy labels, which poses a major challenge for training deep neural networks as they easily memorize the labels. Noise-robust loss functions have emerged as a notable strategy to counteract this…

Machine Learning · Computer Science 2025-01-28 Max Staats , Matthias Thamm , Bernd Rosenow

Segmentation of pathological images is essential for accurate disease diagnosis. The quality of manual labels plays a critical role in segmentation accuracy; yet, in practice, the labels between pathologists could be inconsistent, thus…

Image and Video Processing · Electrical Eng. & Systems 2021-04-07 Li Xiao , Yinhao Li , Luxi Qv , Xinxia Tian , Yijie Peng , S. Kevin Zhou

We propose a generalized focal loss function based on the Tversky index to address the issue of data imbalance in medical image segmentation. Compared to the commonly used Dice loss, our loss function achieves a better trade off between…

Computer Vision and Pattern Recognition · Computer Science 2018-10-19 Nabila Abraham , Naimul Mefraz Khan

Learning segmentation from noisy labels is an important task for medical image analysis due to the difficulty in acquiring highquality annotations. Most existing methods neglect the pixel correlation and structural prior in segmentation,…

Computer Vision and Pattern Recognition · Computer Science 2021-07-22 Shuailin Li , Zhitong Gao , Xuming He

We propose Region-wise (RW) loss for biomedical image segmentation. Region-wise loss is versatile, can simultaneously account for class imbalance and pixel importance, and it can be easily implemented as the pixel-wise multiplication…

Image and Video Processing · Electrical Eng. & Systems 2022-03-30 Juan Miguel Valverde , Jussi Tohka

Label noise and class imbalance commonly coexist in real-world data. Previous works for robust learning, however, usually address either one type of the data biases and underperform when facing them both. To mitigate this gap, this work…

Machine Learning · Computer Science 2023-09-06 Shenwang Jiang , Jianan Li , Jizhou Zhang , Ying Wang , Tingfa Xu

The loss function is crucial to machine learning, especially in supervised learning frameworks. It is a fundamental component that controls the behavior and general efficacy of learning algorithms. However, despite their widespread use,…

Machine Learning · Computer Science 2026-02-09 Soumi Mahato , Lineesh M. C

This work presents a study on label noise in medical image segmentation by considering a noise model based on Gaussian field deformations. Such noise is of interest because it yields realistic looking segmentations and because it is…

Computer Vision and Pattern Recognition · Computer Science 2023-07-11 Marcus Nordström , Henrik Hult , Atsuto Maki

In medical image processing, accurate diagnosis is of paramount importance. Leveraging machine learning techniques, particularly top-rank learning, shows significant promise by focusing on the most crucial instances. However, challenges…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Xiaotong Ji , Ryoma Bise , Seiichi Uchida

Medical image segmentation is crucial in the field of medical imaging, aiding in disease diagnosis and surgical planning. Most established segmentation methods rely on supervised deep learning, in which clean and precise labels are…

Computer Vision and Pattern Recognition · Computer Science 2024-09-27 Jiahua Dong , Yue Zhang , Qiuli Wang , Ruofeng Tong , Shihong Ying , Shaolin Gong , Xuanpu Zhang , Lanfen Lin , Yen-Wei Chen , S. Kevin Zhou

Label noise is a critical problem in medical image segmentation, often arising from the inherent difficulty of manual annotation. Models trained on noisy data are prone to overfitting, which degrades their generalization performance. While…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Wesam Moustafa , Hossam Elsafty , Helen Schneider , Lorenz Sparrenberg , Rafet Sifa

Medical experts often manually segment images to obtain diagnostic statistics and discard the resulting annotations. We aim to train segmentation models to alleviate this burden, but constrained to the retained summary statistics (e.g., the…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Omkar Kulkarni , Edward Raff , Tim Oates

Deep-learning has proved in recent years to be a powerful tool for image analysis and is now widely used to segment both 2D and 3D medical images. Deep-learning segmentation frameworks rely not only on the choice of network architecture but…

Computer Vision and Pattern Recognition · Computer Science 2017-09-19 Carole H Sudre , Wenqi Li , Tom Vercauteren , Sébastien Ourselin , M. Jorge Cardoso

Dice loss is widely used for medical image segmentation, and many improvement loss functions based on such loss have been proposed. However, further Dice loss improvements are still possible. In this study, we reconsidered the use of Dice…

Image and Video Processing · Electrical Eng. & Systems 2022-07-19 Sota Kato , Kazuhiro Hotta

Versatile medical image segmentation (VMIS) targets the segmentation of multiple classes, while obtaining full annotations for all classes is often impractical due to the time and labor required. Leveraging partially labeled datasets (PLDs)…

Computer Vision and Pattern Recognition · Computer Science 2025-09-08 Shengqian Zhu , Jiafei Wu , Xiaogang Xu , Chengrong Yu , Ying Song , Zhang Yi , Guangjun Li , Junjie Hu
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