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A major open challenge in neuroscience is the ability to measure and perturb neural activity in vivo from well-defined neural sub-populations at cellular resolution anywhere in the brain. However, limitations posed by scattering and…

Biological Physics · Physics 2017-11-10 Shay Ohayon , Antonio Miguel Caravaca-Aguirre , Rafael Piestun , James J. DiCarlo

Multimode fibers (MMFs) are attractive ultra-thin replacements for state-of-the-art endoscopes, but the phase randomization in propagation through MMFs poses a major hurdle for imaging and focusing of light. Recently, this challenge has…

Optics · Physics 2015-06-30 Shamir Rosen , Doron Gilboa , Ori Katz , Yaron Silberberg

Progress in neuroscience constantly relies on the development of new techniques to investigate the complex dynamics of neuronal networks. An ongoing challenge is to achieve minimally-invasive and high-resolution observations of neuronal…

Multimode fibers (MMF) are an example of a highly scattering medium which scramble the coherent light propagating within them and produce seemingly random patterns. Thus, for applications such as imaging and image projection through a MMF,…

Multimode fibers (MMFs) can transmit multiple guided modes simultaneously, making them a promising platform for high-resolution biomedical imaging, endoscopy and high-bandwidth optical communication. However, their complex modal behavior,…

Optics · Physics 2026-05-28 Dvir Marsh , Lior Fridman , Stav Lotan , Amit Kam , Shie Mannor , Guy Bartal

Endoscopic optical imaging using a single multimode fiber (MMF) has emerged as a promising approach for highly compact, minimally invasive, and high-resolution imaging. Unlike conventional fiber bundles, MMF-based endomicroscopes exploit…

Multimode optical fibers (MMFs) have gained renewed interest in the past decade, emerging as a way to boost optical communication data-rates in the context of an expected saturation of current single-mode fiber-based networks. They are also…

Multimode fibres (MMF) are remarkable high-capacity information channels owing to the large number of transmitting fibre modes, and have recently attracted significant renewed interest in applications such as optical communication, imaging,…

Optics · Physics 2018-08-27 Pengfei Fan , Tianrui Zhao , Lei Su

The ability to form images through hair-thin optical fibres promises to open up new applications from biomedical imaging to industrial inspection. Unfortunately, deployment has been limited because small changes in mechanical deformation…

In today's information age, advanced fiber optic transmission technology is of paramount importance. Multimode fibers (MMFs) using space-division multiplexing (SDM) are promising for improved transmission capacity, connection flexibility,…

Conventional endoscopes comprise a bundle of optical fibers, associating one fiber for each pixel in the image. In principle, this can be reduced to a single multimode optical fiber (MMF), the width of a human hair, with one fiber…

Image and Video Processing · Electrical Eng. & Systems 2023-07-13 Abdullah Abdulaziz , Simon Peter Mekhail , Yoann Altmann , Miles J. Padgett , Stephen McLaughlin

Recently, fluorescence-based optical techniques have emerged as a powerful tool to probe information in the mammalian brain. However, tissue heterogeneities prevent clear imaging of deep neuron bodies due to light scattering. While several…

Fluorescence is a powerful mean to probe information processing in the mammalian brain. However, neuronal tissues are highly heterogeneous and thus opaque to light. A wide set of non-invasive or invasive techniques for scattered light…

Optics · Physics 2020-05-11 Claudio Moretti , Sylvain Gigan

Multimode fibres are becoming increasingly attractive in optical endoscopy as they promise to enable unparalleled miniaturisation, spatial resolution and cost as compared to conventional fibre bundle-based counterpart. However, achieving…

Medical Physics · Physics 2024-06-05 Tianrui Zhao , Michelle T. Ma , Sebastien Ourselin , Tom Vercauteren , Wenfeng Xia

Imaging through optical multimode fibers (MMFs) has the potential to enable hair-thin endoscopes that reduce the invasiveness of imaging deep inside tissues and organs. Current approaches predominantly require active wavefront shaping and…

Optics · Physics 2021-12-13 Szu-Yu Lee , Vicente J. Parot , Brett E. Bouma , Martin Villiger

Multimode fibers (MMFs) offer a cost-effective connection solution for small and medium length networks. However, data rates through multimode fibers are traditionally limited by modal dispersion. Signal processing and Multiple-Input…

Optics · Physics 2011-10-06 Kumar Appaiah , Sagi Zisman , Sriram Vishwanath , Seth R. Bank

In this work we demonstrate 3D imaging using two-photon excitation through a 20 cm long multimode optical fiber (MMF) of 350 micrometers diameter. The imaging principle is similar to single photon fluorescence through a MMF, except that a…

Optics · Physics 2016-01-20 Edgar E. Morales-Delgado , Demetri Psaltis , Christophe Moser

Understanding how networks of neurons process information is one of the key challenges in modern neuroscience. A necessary step to achieve this goal is to be able to observe the dynamics of large populations of neurons over a large area of…

Image and Video Processing · Electrical Eng. & Systems 2022-03-09 Pingfan Song , Herman Verinaz Jadan , Carmel L. Howe , Amanda J. Foust , Pier Luigi Dragotti

Confocal and multi-photon microscopy are widely used for in-vivo fluorescence imaging of biological tissues such as the brain, offering non-invasive access up to ~1 mm depth without major loss in performance. A recently-developed…

Super-resolution microscopy normally requiring complex and cumbersome optics is not applicable for in situ imaging through a narrow channel. Here, we demonstrate single hair-thin multimode fiber (MMF) endoscope (less than 250 ${\mu}m$) for…

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