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Low-dose computed tomography (LDCT) reduces patient radiation exposure but introduces substantial noise that degrades image quality and hinders diagnostic accuracy. Existing denoising approaches often require many diffusion steps, limiting…

Medical Physics · Physics 2025-10-29 Qiang Li , Mojtaba Safari , Shansong Wang , Huiqiao Xie , Jie Ding , Tonghe Wang , Xiaofeng Yang

The purpose of this study is to present and compare three denoising diffusion probabilistic models (DDPMs) that generate 3D $T_1$-weighted MRI human brain images. Three DDPMs were trained using 80,675 image volumes from 42,406 subjects…

Image and Video Processing · Electrical Eng. & Systems 2025-11-03 Samuel W. Remedios , Aaron Carass , Jerry L. Prince , Blake E. Dewey

Recently, more and more attention is drawn to the field of medical image synthesis across modalities. Among them, the synthesis of computed tomography (CT) image from T1-weighted magnetic resonance (MR) image is of great importance,…

Computer Vision and Pattern Recognition · Computer Science 2017-11-10 Lei Xiang , Qian Wang , Xiyao Jin , Dong Nie , Yu Qiao , Dinggang Shen

In this work, we address the challenge of multi-task image generation with limited data for denoising diffusion probabilistic models (DDPM), a class of generative models that produce high-quality images by reversing a noisy diffusion…

Machine Learning · Computer Science 2023-11-29 Delaram Pirhayatifard , Mohammad Taha Toghani , Guha Balakrishnan , César A. Uribe

We propose a novel pipeline for the generation of synthetic ultrasound images via Denoising Diffusion Probabilistic Models (DDPMs) guided by cardiac semantic label maps. We show that these synthetic images can serve as a viable substitute…

Image and Video Processing · Electrical Eng. & Systems 2023-08-16 David Stojanovski , Uxio Hermida , Pablo Lamata , Arian Beqiri , Alberto Gomez

Low-dose computed tomography (LDCT) is an important topic in the field of radiology over the past decades. LDCT reduces ionizing radiation-induced patient health risks but it also results in a low signal-to-noise ratio (SNR) and a potential…

Image and Video Processing · Electrical Eng. & Systems 2022-10-03 Wenjun Xia , Qing Lyu , Ge Wang

Computed tomography (CT) involves a patient's exposure to ionizing radiation. To reduce the radiation dose, we can either lower the X-ray photon count or down-sample projection views. However, either of the ways often compromises image…

Image and Video Processing · Electrical Eng. & Systems 2023-10-12 Wenjun Xia , Yongyi Shi , Chuang Niu , Wenxiang Cong , Ge Wang

Generative artificial intelligence (AI) has been playing an important role in various domains. Leveraging its high capability to generate high-fidelity and diverse synthetic data, generative AI is widely applied in diagnostic tasks, such as…

Computer Vision and Pattern Recognition · Computer Science 2025-11-24 Yifan Jiang , Ahmad Shariftabrizi , Venkata SK. Manem

This paper strives to generate a synthetic computed tomography (CT) image from a magnetic resonance (MR) image. The synthetic CT image is valuable for radiotherapy planning when only an MR image is available. Recent approaches have made…

Image and Video Processing · Electrical Eng. & Systems 2021-07-20 Zenglin Shi , Pascal Mettes , Guoyan Zheng , Cees Snoek

Detecting anomalies in brain MRI scans using supervised deep learning methods presents challenges due to anatomical diversity and labor-intensive requirement of pixel-level annotations. Generative models like Denoising Diffusion…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Vivek Kumar Trivedi , Bheeshm Sharma , P. Balamurugan

Magnetic resonance imaging (MRI) is a common and life-saving medical imaging technique. However, acquiring high signal-to-noise ratio MRI scans requires long scan times, resulting in increased costs and patient discomfort, and decreased…

Image and Video Processing · Electrical Eng. & Systems 2023-02-07 Tiange Xiang , Mahmut Yurt , Ali B Syed , Kawin Setsompop , Akshay Chaudhari

As acquiring MRIs is expensive, neuroscience studies struggle to attain a sufficient number of them for properly training deep learning models. This challenge could be reduced by MRI synthesis, for which Generative Adversarial Networks…

Image and Video Processing · Electrical Eng. & Systems 2023-09-08 Wei Peng , Ehsan Adeli , Tomas Bosschieter , Sang Hyun Park , Qingyu Zhao , Kilian M. Pohl

Attenuation correction is an essential requirement of positron emission tomography (PET) image reconstruction to allow for accurate quantification. However, attenuation correction is particularly challenging for PET-MRI as neither PET nor…

This study aims to improve photon counting CT (PCCT) image resolution using denoising diffusion probabilistic models (DDPM). Although DDPMs have shown superior performance when applied to various computer vision tasks, their effectiveness…

Computer Vision and Pattern Recognition · Computer Science 2024-08-29 Chuang Niu , Christopher Wiedeman , Mengzhou Li , Jonathan S Maltz , Ge Wang

Ultra-high resolution images are desirable in photon counting CT (PCCT), but resolution is physically limited by interactions such as charge sharing. Deep learning is a possible method for super-resolution (SR), but sourcing paired training…

Image and Video Processing · Electrical Eng. & Systems 2024-02-27 Christopher Wiedeman , Chuang Niu , Mengzhou Li , Bruno De Man , Jonathan S Maltz , Ge Wang

MRI-guided radiation treatment planning is widely applied because of its superior soft-tissue contrast and no ionization radiation compared to CT-based planning. In this regard, synthetic CT (sCT) images should be generated from the…

Medical Physics · Physics 2021-05-14 Abbas Bahrami , Alireza Karimian , Hossein Arabi

Accurate MRI-to-CT synthesis could enable MR-only pelvic workflows by providing CT-like images with bone details while avoiding additional ionizing radiation. In this work, we investigate recently proposed drifting models for synthesizing…

Image and Video Processing · Electrical Eng. & Systems 2026-04-07 Qing Lyu , Jianxu Wang , Jeremy Hudson , Ge Wang , Chirstopher T. Whitlow

The scarcity of publicly available medical imaging data limits the development of effective AI models. This work proposes a memory-efficient patch-wise denoising diffusion probabilistic model (DDPM) for generating synthetic medical images,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-17 Kathrin Khadra , Utku Türkbey

This paper proposes a novel approach to spectral computed tomography (CT) material decomposition that uses the recent advances in generative diffusion models (DMs) for inverse problems. Spectral CT and more particularly photon-counting CT…

Purpose: This study aims to develop and validate a method for synthesizing 3D nephrographic phase images in CT urography (CTU) examinations using a diffusion model integrated with a Swin Transformer-based deep learning approach. Materials…