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Knowing brain connectivity is of great importance both in basic research and for clinical applications. We are proposing a method to infer directed connectivity from zero-lag covariances of neuronal activity recorded at multiple sites. This…

Neurons and Cognition · Quantitative Biology 2018-04-10 Jonathan Schiefer , Alexander Niederbühl , Volker Pernice , Carolin Lennartz , Pierre LeVan , Jürgen Henning , Stefan Rotter

Objective: Schizophrenia seriously affects the quality of life. To date, both simple (linear discriminant analysis) and complex (deep neural network) machine learning methods have been utilized to identify schizophrenia based on functional…

Machine Learning · Computer Science 2021-05-11 Tian Wang , Anastasios Bezerianos , Andrzej Cichocki , Junhua Li

The transmission or reception of packets passing between computers can be represented in terms of time-stamped events and the resulting activity understood in terms of point-processes. Interestingly, in the disparate domain of neuroscience,…

Applications · Statistics 2017-11-28 Alex Gibberd , Jordan Noble , Edward Cohen

Some evidence suggests that people with autism spectrum disorder exhibit patterns of brain functional dysconnectivity relative to their typically developing peers, but specific findings have yet to be replicated. To facilitate this…

Methodology · Statistics 2025-03-03 Hyoshin Kim , Sujit K. Ghosh , Emily C. Hector

Identifying brain regions that exhibit altered functional connectivity across cognitive or emotional states is a key problem in neuroscience. Existing methods, such as edge-wise testing, seed-based psychophysiological interaction (PPI)…

Methodology · Statistics 2026-02-12 Shira Yoffe , Ziv Ben-Zion , Guy Gurevitch , Talma Hendler , Malka Gorfine , Ariel Jaffe

Overparameterized neural networks often contain many removable neurons, yet what makes a neuron redundant remains poorly understood. Existing pruning criteria commonly rely on local quantities such as weight magnitude, activation strength,…

Machine Learning · Computer Science 2026-05-21 Yongyu Wang

Inferring a binary connectivity graph from resting-state fMRI data for a single subject requires making several methodological choices and assumptions that can significantly affect the results. In this study, we investigate the robustness…

Methodology · Statistics 2025-03-20 Alice Chevaux , Ali Fahkar , Kévin Polisano , Irène Gannaz , Sophie Achard

The wide variety of brain imaging technologies allows us to exploit information inherent to different data modalities. The richness of multimodal datasets may increase predictive power and reveal latent variables that otherwise would have…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 Alvaro Ulloa , Sergey Plis , Vince Calhoun

Recent advancements in measurement techniques have resulted in an increasing amount of data on neural activities recorded in parallel, revealing largely heterogeneous correlation patterns across neurons. Yet, the mechanistic origin of this…

Disordered Systems and Neural Networks · Physics 2024-04-26 Moritz Layer , Moritz Helias , David Dahmen

Several data-driven approaches based on information theory have been proposed for analyzing high-order interactions involving three or more components of a network system. Most of these methods are defined only in the time domain and rely…

Applications · Statistics 2025-03-18 Yuri Antonacci , Chiara Bara' , Laura Sparacino , Gorana Mijatovic , Ludovico Minati , Luca Faes

The primary goal of this paper is to develop a method that quantifies how activity in one brain region can explain future activity in another region. Here, we propose the mixed effects spectral vector-autoregressive (ME-SpecVar) model to…

Applications · Statistics 2022-10-07 Anastasiia Malinovskaia

Functional connectivity (FC) studies have demonstrated the overarching value of studying the brain and its disorders through the undirected weighted graph of fMRI correlation matrix. Most of the work with the FC, however, depends on the way…

Neurons and Cognition · Quantitative Biology 2021-12-09 Usman Mahmood , Zening Fu , Vince Calhoun , Sergey Plis

Network neuroscience shed some light on the functional and structural modifications occurring to the brain associated with the phenomenology of schizophrenia. In particular, resting-state functional networks have helped our understanding of…

Neurons and Cognition · Quantitative Biology 2021-04-30 Rossana Mastrandrea , Fabrizio Piras , Andrea Gabrielli , Nerisa Banaj , Guido Caldarelli , Gianfranco Spalletta , Tommaso Gili

Schizophrenia (SZ) is a brain disorder leading to detached mind's normally integrated processes. Hence, the exploration of the symptoms in relation to functional connectivity (FC) had great relevance in the field. FC can be investigated on…

Neurons and Cognition · Quantitative Biology 2026-04-08 Davide Coluzzi , Giuseppe Baselli

This work considers a continuous framework to characterize the population-level variability of structural connectivity. Our framework assumes the observed white matter fiber tract endpoints are driven by a latent random function defined…

Computation · Statistics 2022-07-19 William Consagra , Martin Cole , Zhengwu Zhang

There has been increasing interests in learning resting-state brain functional connectivity of autism disorders using functional magnetic resonance imaging (fMRI) data. The data in a standard brain template consist of over 200,000 voxel…

Methodology · Statistics 2016-03-22 Jichun Xie , Jian Kang

An increasingly important brain function analysis modality is functional connectivity analysis which regards connections as statistical codependency between the signals of different brain regions. Graph-based analysis of brain connectivity…

Signal Processing · Electrical Eng. & Systems 2024-01-08 Fengfan Zhao , Ercan Engin Kuruoglu

In neuroscience, functional brain connectivity describes the connectivity between brain regions that share functional properties. Neuroscientists often characterize it by a time series of covariance matrices between functional measurements…

Methodology · Statistics 2019-07-09 Zhenhua Lin , Dehan Kong , Qiang Sun

We use methods from computational algebraic topology to study functional brain networks, in which nodes represent brain regions and weighted edges encode the similarity of fMRI time series from each region. With these tools, which allow one…

Quantitative Methods · Quantitative Biology 2020-08-27 Bernadette J. Stolz , Tegan Emerson , Satu Nahkuri , Mason A. Porter , Heather A. Harrington

The counter-intuitive phenomenon of coherence resonance describes a non-monotonic behavior of the regularity of noise-induced oscillations in the excitable regime, leading to an optimal response in terms of regularity of the excited…

Adaptation and Self-Organizing Systems · Physics 2021-03-24 Emre Baspinar , Leonhard Schülen , Simona Olmi , Anna Zakharova