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Large Language Models (LLMs) show promise in biomedicine but lack true causal understanding, relying instead on correlations. This paper envisions causal LLM agents that integrate multimodal data (text, images, genomics, etc.) and perform…

Artificial Intelligence · Computer Science 2025-05-23 Adib Bazgir , Amir Habibdoust Lafmajani , Yuwen Zhang

Large Language Models (LLMs) have demonstrated remarkable capabilities in various reasoning and generation tasks. However, their proficiency in complex causal reasoning, discovery, and estimation remains an area of active development, often…

Artificial Intelligence · Computer Science 2025-09-03 Adib Bazgir , Amir Habibdoust , Yuwen Zhang , Xing Song

In this paper, we propose the use of causal inference techniques for survival function estimation and prediction for subgroups of the data, upto individual units. Tree ensemble methods, specifically random forests were modified for this…

Econometrics · Economics 2018-03-23 Vikas Ramachandra

Current machine learning approaches to medical diagnosis often rely on correlational patterns between symptoms and diseases, risking misdiagnoses when symptoms are ambiguous or common across multiple conditions. In this work, we move beyond…

Machine Learning · Computer Science 2025-03-26 Mehul Shetty , Connor Jordan

Breast cancer is the most common cancers and early detection from mammography screening is crucial in improving patient outcomes. Assessing mammographic breast density is clinically important as the denser breasts have higher risk and are…

Image and Video Processing · Electrical Eng. & Systems 2022-06-27 Charles Lu , Ken Chang , Praveer Singh , Jayashree Kalpathy-Cramer

Breast cancer remains the most commonly diagnosed malignancy among women in the developed world. Early detection through mammography screening plays a pivotal role in reducing mortality rates. While computer-aided diagnosis (CAD) systems…

Computer Vision and Pattern Recognition · Computer Science 2025-10-30 Shunjie-Fabian Zheng , Hyeonjun Lee , Thijs Kooi , Ali Diba

In healthcare, it is essential to explain the decision-making process of machine learning models to establish the trustworthiness of clinicians. This paper introduces BI-RADS-Net, a novel explainable deep learning approach for cancer…

Computer Vision and Pattern Recognition · Computer Science 2021-10-11 Boyu Zhang , Aleksandar Vakanski , Min Xian

Breast cancer is one of the two cancers responsible for the most deaths in women, with about 42,000 deaths each year in the US. That there are over 300,000 breast cancers newly diagnosed each year suggests that only a fraction of the…

Machine Learning · Computer Science 2024-08-30 Xia Jiang , Yijun Zhou , Alan Wells , Adam Brufsky

Estimating causal interactions in complex dynamical systems is an important problem encountered in many fields of current science. While a theoretical solution for detecting the causal interactions has been previously formulated in the…

Data Analysis, Statistics and Probability · Physics 2020-01-20 Jakub Kořenek , Jaroslav Hlinka

Causal reasoning is viewed as crucial for achieving human-level machine intelligence. Recent advances in language models have expanded the horizons of artificial intelligence across various domains, sparking inquiries into their potential…

Computation and Language · Computer Science 2024-05-02 Sirui Chen , Bo Peng , Meiqi Chen , Ruiqi Wang , Mengying Xu , Xingyu Zeng , Rui Zhao , Shengjie Zhao , Yu Qiao , Chaochao Lu

In this paper, we describe a dataset relating to cellular and physical conditions of patients who are operated upon to remove colorectal tumours. This data provides a unique insight into immunological status at the point of tumour removal,…

Machine Learning · Computer Science 2016-11-15 Chris Roadknight , Uwe Aickelin , John Scholefield , Lindy Durrant

In this paper we present a comprehensive view of prominent causal discovery algorithms, categorized into two main categories (1) assuming acyclic and no latent variables, and (2) allowing both cycles and latent variables, along with…

Artificial Intelligence · Computer Science 2017-09-13 Karamjit Singh , Garima Gupta , Vartika Tewari , Gautam Shroff

A precise assessment of the risk of breast lesions can greatly lower it and assist physicians in choosing the best course of action. To categorise breast lesions, the majority of current computer-aided systems only use characteristics from…

Image and Video Processing · Electrical Eng. & Systems 2025-08-25 Muhaisin Tiyumba Nantogmah , Abdul-Barik Alhassan , Salamudeen Alhassan

Collectively, lung cancer, breast cancer and melanoma was diagnosed in over 535,340 people out of which, 209,400 deaths were reported [13]. It is estimated that over 600,000 people will be diagnosed with these forms of cancer in 2015. Most…

Machine Learning · Computer Science 2015-09-29 Mohnish Chakravarti , Tanay Kothari

The biological literature is rich with sentences that describe causal relations. Methods that automatically extract such sentences can help biologists to synthesize the literature and even discover latent relations that had not been…

Information Retrieval · Computer Science 2019-04-04 Justin Wood , Nicholas J. Matiasz , Alcino J. Silva , William Hsu , Alexej Abyzov , Wei Wang

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

Cancer is one of the diseases that kill the most women in the world, with breast cancer being responsible for the highest number of cancer cases and consequently deaths. However, it can be prevented by early detection and, consequently,…

Machine Learning · Computer Science 2025-09-23 João Manoel Herrera Pinheiro , Marcelo Becker

The advent of large scale, high-throughput genomic screening has introduced a wide range of tests for diagnostic purposes. Prominent among them are tests using miRNA expression levels. Genomics and proteomics now provide expression levels…

Genomics · Quantitative Biology 2016-11-08 Neerja Garikipati

Improved computational power has enabled different disciplines to predict causal relationships among modeled variables using Bayesian network inference. While many alternative algorithms have been proposed to improve the efficiency and…

Machine Learning · Statistics 2025-08-19 Habibolla Latifizadeh , Anika C. Pirkey , Alanna Gould , David J. Klinke

This article presents a novel method for causal discovery with generalized structural equation models suited for analyzing diverse types of outcomes, including discrete, continuous, and mixed data. Causal discovery often faces challenges…

Methodology · Statistics 2023-10-26 Minjie Wang , Xiaotong Shen , Wei Pan