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Knowledge graphs and structural causal models have each proven valuable for organizing biomedical knowledge and estimating causal effects, but remain largely disconnected: knowledge graphs encode qualitative relationships focusing on facts…
Objective: To discover biomarkers and uncover the mechanism of Cold/Hot ZHENG (syndrome in traditional Chinese medicine) chronic gastritis (CG) and Cold/Hot herbs in traditional Chinese medicine (TCM) formulae on systematic biology.…
The sequential recommendation systems capture users' dynamic behavior patterns to predict their next interaction behaviors. Most existing sequential recommendation methods only exploit the local context information of an individual…
In order to model the evolution of user preference, we should learn user/item embeddings based on time-ordered item purchasing sequences, which is defined as Sequential Recommendation (SR) problem. Existing methods leverage sequential…
This paper details a technical plan for building a clinical case database for Traditional Chinese Medicine (TCM) using web scraping. Leveraging multiple platforms, including 360doc, we gathered over 5,000 TCM clinical cases, performed data…
Patient-Centric Knowledge Graphs (PCKGs) represent an important shift in healthcare that focuses on individualized patient care by mapping the patient's health information in a holistic and multi-dimensional way. PCKGs integrate various…
Drug recommendation (DR) systems aim to support healthcare professionals in selecting appropriate medications based on patients' medical conditions. State-of-the-art approaches utilize deep learning techniques for improving DR, but fall…
One of the challenges in healthcare processes, especially those related to multi-morbid patients who suffer from multiple disorders simultaneously, is not connecting the disorders in patients to process events and not linking events'…
Epilepsy is a prevalent neurological disease with millions of patients worldwide. Many patients have turned to alternative medicine due to the limited efficacy and side effects of conventional antiepileptic drugs. In this study, we…
Recent recommender system advancements have focused on developing sequence-based and graph-based approaches. Both approaches proved useful in modeling intricate relationships within behavioral data, leading to promising outcomes in…
Traditional Chinese medicine, as an essential component of traditional medicine, contains active ingredients that serve as a crucial source for modern drug development, holding immense therapeutic potential and development value. A…
It is a long-standing challenge in modern recommender systems to effectively make recommendations for new users, namely the cold-start problem. Cross-Domain Recommendation (CDR) has been proposed to address this challenge, but current ways…
We present an end-to-end, interpretable, deep-learning architecture to learn a graph kernel that predicts the outcome of chronic disease drug prescription. This is achieved through a deep metric learning collaborative with a Support Vector…
Recommendation system plays an important role in online web applications. Sequential recommender further models user short-term preference through exploiting information from latest user-item interaction history. Most of the sequential…
The integration of complementary medicine into oncology represents a paradigm shift that has seen to increasing adoption of Traditional Chinese Medicine (TCM) as an adjuvant to radiotherapy. About twenty-five years since the formal…
Traditional recommender systems estimate user preference on items purely based on historical interaction records, thus failing to capture fine-grained yet dynamic user interests and letting users receive recommendation only passively.…
Traditional Chinese medicine (TCM) has relied on specific combinations of herbs in prescriptions to treat various symptoms and signs for thousands of years. Predicting TCM prescriptions poses a fascinating technical challenge with…
A comprehensive pharmaceutical recommendation system was designed based on the patients and drugs features extracted from Drugs.com and Druglib.com. First, data from these databases were combined, and a dataset of patients and drug…
Background: Retrieval augmented generation (RAG) technology can empower large language models (LLMs) to generate more accurate, professional, and timely responses without fine tuning. However, due to the complex reasoning processes and…
Most of the existing medicine recommendation systems that are mainly based on electronic medical records (EMRs) are significantly assisting doctors to make better clinical decisions benefiting both patients and caregivers. Even though the…