Related papers: Joint regional uptake quantification of Thorium-22…
SPECT can enable the quantification of activity uptake in lesions and at-risk organs in {\alpha}-particle-emitting radiopharmaceutical therapies ({\alpha}-RPTs). But this quantification is challenged by the low photon counts, complicated…
Single-photon emission computed tomography (SPECT) provides a mechanism to estimate regional isotope uptake in lesions and at-risk organs after administration of {\alpha}-particle-emitting radiopharmaceutical therapies ({\alpha}-RPTs).…
SPECT provides a mechanism to perform absorbed-dose quantification tasks for $\alpha$-particle radiopharmaceutical therapies ($\alpha$-RPTs). However, quantitative SPECT for $\alpha$-RPT is challenging due to the low number of detected…
Radiopharmaceutical therapies (RPTs) present a major opportunity to improve cancer therapy. Although many current RPTs use the same injected activity for all patients, there is interest in using absorbed dose measurements to enable…
This work aims to investigate the accuracy of quantitative SPECT imaging of $^{177}$Lu in the presence of $^{90}$Y, which occurs in dual-isotope radiopharmaceutical therapy (RPT) involving both isotopes. We used the GATE Monte Carlo…
Introduction: Terbium-149 ($^{149}$Tb) is a promising radionuclide for targeted $\alpha$ therapy that has a non-zero branching ratio (BR) for positron decay. However, its relatively low positron branching fraction and multiple prompt…
Many clinical applications depend critically on the accurate differentiation and classification of different types of materials in patient anatomy. This work introduces a unified framework for accurate nonlinear material decomposition and…
Intensity-modulated proton therapy (IMPT) employs proton radiation rather than conventional X-rays to treat cancerous tumors. This approach offers significant advantages by minimizing the radiation exposure of surrounding healthy tissue,…
Prostate cancer is the most common disease in men and the second leading cause of death from cancer. Generic large imaging instruments used in cancer diagnosis have sensitivity, spatial resolution, and contrast inadequate for the task of…
Microdosimetry provides a superior characterization of the radiation field compared to conventional LET-based methodology, and for this reason it has become increasingly attractive for quality assurance in particle therapy. However, the…
Quantitative measures of dopamine transporter (DaT) uptake in caudate, putamen, and globus pallidus (GP) have potential as biomarkers for measuring the severity of Parkinson disease. Reliable quantification of this uptake requires accurate…
Proton radiography combined with X-ray computed tomography (CT) has been proposed to obtain a patient-specific calibration curve and reduce range uncertainties in cancer treatment with charged particles. The main aim of this study was to…
Improving the coincidence time resolution (CTR) of time-of-flight positron emission tomography (TOF-PET) systems to achieve a higher signal-to-noise ratio (SNR) gain or even direct positron emission imaging (dPEI) is of paramount importance…
Purpose: To present a methodology to analyze the variation of RBE with fractionation from clinical data of tumor control probability (TCP) and to apply it to study the response of prostate cancer to proton therapy. M&M: We analyzed the…
Charged particle beams are used in Particle Therapy (PT) to treat oncological patients due to their selective dose deposition in tissues and to their high biological effect in killing cancer cells with respect to photons and electrons used…
Positron emission tomography (PET) scans expose patients to radiation, which can be mitigated by reducing the dose, albeit at the cost of diminished quality. This makes low-dose (LD) PET recovery an active research area. Previous studies…
PET imaging is a non-invasive technique for particle range verification in proton therapy. It is based on measuring the beta+ annihilations caused by nuclear interactions of the protons in the patient. In this work we present measurements…
In SPECT imaging, the identification and detection of a lesion rely either on visual inspection of the reconstructed tomographic images or post-processing image analysis methods. Both approaches do not provide the capability to attribute a…
Multi-energy CT takes advantage of the non-linearly varying attenuation properties of elemental media with respect to energy, enabling more precise material identification than single-energy CT. The increased precision comes with the cost…
In this study, we introduce a Compton SPECT system for whole-body imaging of Actinium-225 (225Ac), one of the trending radionuclides for targeted alpha therapy (TAT). The Compton SPECT system enables multi-energy gamma photon detection with…