First experimental proof of PET imaging based on multi-anode MCP-PMTs with Cherenkov radiator-integrated window
Abstract
Improving the coincidence time resolution (CTR) of time-of-flight positron emission tomography (TOF-PET) systems to achieve a higher signal-to-noise ratio (SNR) gain or even direct positron emission imaging (dPEI) is of paramount importance for many advanced new clinical applications of PET imaging. This places higher demands on the timing performance of all aspects of PET systems. One effective approach is to use microchannel plate photomultiplier tubes (MCP-PMTs) for prompt Cherenkov photon detection. In this study, we developed a dual-module Cherenkov PET imaging experimental platform, utilising our proprietary 8 * 8-anode Cherenkov radiator-integrated window MCP-PMTs in combination with custom-designed multi-channel electronics, and designed a specific calibration and correction method for the platform. Using this platform, a CTR of 103 ps FWHM was achieved. We overcame the limitations of single-anode detectors in previous experiments, significantly enhanced imaging efficiency and achieved module-level Cherenkov PET imaging for the first time. Imaging experiments involving radioactive sources and phantoms of various shapes and types were conducted, which preliminarily validated the feasibility and advancement of this imaging method. In addition, the effects of normalisation correction and the interaction probability between the gamma rays and the MCP on the images and experimental results were analysed and verified.
Keywords
Cite
@article{arxiv.2502.07195,
title = {First experimental proof of PET imaging based on multi-anode MCP-PMTs with Cherenkov radiator-integrated window},
author = {Weiyan Pan and Lingyue Chen and Guorui Huang and Jun Hu and Wei Hou and Xianchao Huang and Xiaorou Han and Xiaoshan Jiang and Zhen Jin and Daowu Li and Jingwen Li and Shulin Liu and Zehong Liang and Lishuang Ma and Zhe Ning and Sen Qian and Ling Ren and Jianning Sun and Shuguang Si and Yunhua Sun and Long Wei and Ning Wang and Qing Wei and Qi Wu and Tianyi Wang and Xin Wang and Xingchao Wang and Yangfu Wang and Yifang Wang and Yingjie Wang and Zhi Wang and Hang Yuan and Jingbo Ye and Xiongbo Yan and Meiling Zhu and Zhiming Zhang},
journal= {arXiv preprint arXiv:2502.07195},
year = {2025}
}
Comments
12 pages, 12 figures, manuscript has been submitted to Physics in Medicine & Biology and is under review