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In this paper we consider mathematical modeling of the dynamics of self-organized patterning of spatially confined human embryonic stem cells (hESCs) treated with BMP4 (gastruloids) described in recent experimental works. In the first part…

Analysis of PDEs · Mathematics 2021-01-12 Prajakta Bedekar , Ilya Timofeyev , Aryeh Warmflash , Misha Perepelitsa

Despite evidence for a hydrodynamic origin of flagellar synchronization between different eukaryotic cells, recent experiments have shown that in single multi-flagellated organisms, coordination hinges instead on direct basal body…

Biological Physics · Physics 2018-10-12 Yujie Liu , Rory Claydon , Marco Polin , Douglas R. Brumley

Cell migration is a fundamental process underlying the survival and function of both unicellular and multicellular organisms. Crawling motility in eukaryotic cells arises from cyclic protrusion and retraction driven by the cytoskeleton,…

Biological Physics · Physics 2025-11-04 Blaž Ivšić , Igor Weber , Piotr Nowakowski , Ana-Sunčana Smith

The hydrodynamic interactions among bacterial cell bodies, flagella, and surrounding boundaries are essential for understanding bacterial motility in complex environments. In this study, we demonstrate that each slender flagellum can be…

Soft Condensed Matter · Physics 2025-01-07 Baopi Liu , Lu Chen , Ji Zhang

We consider a reaction-diffusion process with retardation. The particles, immersed in traps initially, remain inactive until another particle is annihilated spontaneously with a rate $\lambda$ at a certain point $\vec x$. In that case the…

Statistical Mechanics · Physics 2015-06-25 Michael Schulz , Steffen Trimper , Knud Zabrocki

We examine a spatially discrete reaction diffusion model based on the interactions that create a periodic pattern in the Drosophila eye imaginal disc. This model is capable of generating a regular hexagonal pattern of gene expression behind…

Molecular Networks · Quantitative Biology 2010-01-26 Matthew W. Pennington , David K. Lubensky

Traditional locomotion strategies become ineffective at low Reynolds numbers, where viscous forces predominate over inertial forces. To adapt, microorganisms have evolved specialized structures like cilia and flagella for efficient…

Robotics · Computer Science 2024-12-10 Nnamdi C. Chikere , Sofia Lozano Voticky , Quang D. Tran , Yasemin Ozkan-Aydin

Cellular appendages such as cilia and flagella represent universal tools enabling cells and microbes, among other essential functionalities, to propel themselves in diverse environments. In its planktonic, i.e. freely swimming, state the…

The bundling of flagella is known to create a "run" phase, where the bacteria moves in a nearly straight line rather than making changes in direction. Historically, mechanical explanations for the bundling phenomenon intrigued many…

Robotics · Computer Science 2023-10-17 Sangmin Lim , Achyuta Yadunandan , Mohammad Khalid Jawed

Changes in calcium concentration along the sperm flagellum regulate sperm motility and hyperactivation, characterized by an increased flagellar bend amplitude and beat asymmetry, enabling the sperm to reach and penetrate the ovum (egg). The…

Numerical Analysis · Mathematics 2019-10-21 Lucia Carichino , Sarah D. Olson

It is now well established that nearby beating pairs of eukaryotic flagella or cilia typically synchronize in phase. A substantial body of evidence supports the hypothesis that hydrodynamic coupling between the active filaments, combined…

Soft Condensed Matter · Physics 2016-10-12 Raymond E. Goldstein , Eric Lauga , Adriana I. Pesci , Michael R. E. Proctor

Sperm swimming is crucial to fertilise the egg, in nature and in assisted reproductive technologies. Modelling the sperm dynamics involves elasticity, hydrodynamics, internal active forces, and out-of-equilibrium noise. Here we demonstrate…

Soft Condensed Matter · Physics 2023-06-26 C. Maggi , B. Nath , F. Saglimbeni , V. Carmona Sosa , R. Di Leonardo , A. Puglisi

Recent experiments on the green alga Chlamydomonas that swims using synchronized beating of a pair of flagella have revealed that it exhibits a run-and-tumble behavior similar to that of bacteria such as E. Coli. Using a simple purely…

Cell Behavior · Quantitative Biology 2015-06-12 Rachel R. Bennett , Ramin Golestanian

Flagellar motility is critical to natural and many forms of assisted reproduction. Rhythmic beating and wave propagation by the flagellum propels sperm through fluid and enables modulation between penetrative progressive motion, activated…

Biological Physics · Physics 2023-03-02 Meurig T Gallagher , Jackson C Kirkman-Brown , David J Smith

Brownian Dynamics algorithms are widely used for simulating soft-matter and biochemical systems. In recent times, their application has been extended to the simulation of coarse-grained models of cellular networks in simple organisms. In…

Quantitative Methods · Quantitative Biology 2009-11-13 Marco J. Morelli , Pieter Rein ten Wolde

The cellular environment, characterized by its intricate composition and spatial organization, hosts a variety of organelles, ranging from membrane-bound ones to membraneless structures that are formed through liquid-liquid phase…

Soft Condensed Matter · Physics 2026-03-09 Gregor Häfner , Marcus Müller

Cilia and flagella often exhibit synchronized behavior; this includes phase locking, as seen in {\it Chlamydomonas}, and metachronal wave formation in the respiratory cilia of higher organisms. Since the observations by Gray and Rothschild…

Soft Condensed Matter · Physics 2016-05-19 Kirsty Y. Wan , Raymond E. Goldstein

Sperm traverse their microenvironment through viscous fluid by propagating flagellar waves; the waveform emerges as a consequence of elastic structure, internal active moments, and low Reynolds number fluid dynamics. Engineered…

Fluid Dynamics · Physics 2015-02-19 Thomas Montenegro-Johnson , Hermes Gadelha , David J. Smith

Synchronisation is often observed in the swimming of flagellated cells, either for multiple appendages on the same organism or between the flagella of nearby cells. Beating cilia are also seen to synchronise their dynamics. In 1951, Taylor…

Biological Physics · Physics 2021-04-28 Weida Liao , Eric Lauga

Motivated by the swimming of sperm in the non-Newtonian fluids of the female mammalian reproductive tract, we examine the swimming of filaments in the nonlinear viscoelastic Upper Convected Maxwell model. We obtain the swimming velocity and…

Soft Condensed Matter · Physics 2009-11-13 Henry C. Fu , Thomas R. Powers , Charles W. Wolgemuth