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When a new treatment is considered for use, whether a pharmaceutical drug or a search engine ranking algorithm, a typical question that arises is, will its performance exceed that of the current treatment? The conventional way to answer…

Machine Learning · Computer Science 2016-10-27 Nir Rosenfeld , Yishay Mansour , Elad Yom-Tov

Estimation of treatment efficacy of real-world clinical interventions involves working with continuous outcomes such as time-to-death, re-hospitalization, or a composite event that may be subject to censoring. Counterfactual reasoning in…

Machine Learning · Computer Science 2022-08-11 Chirag Nagpal , Mononito Goswami , Keith Dufendach , Artur Dubrawski

A common statistical problem in econometrics is to estimate the impact of a treatment on a treated unit given a control sample with untreated outcomes. Here we develop a generative learning approach to this problem, learning the probability…

Machine Learning · Statistics 2019-10-17 Chirag Modi , Uros Seljak

Foundation models trained on web-scraped datasets propagate societal biases to downstream tasks. While counterfactual generation enables bias analysis, existing methods introduce artifacts by modifying contextual elements like clothing and…

Computer Vision and Pattern Recognition · Computer Science 2024-12-13 Kirill Sirotkin , Marcos Escudero-Viñolo , Pablo Carballeira , Mayug Maniparambil , Catarina Barata , Noel E. O'Connor

The growing integration of machine learning (ML) and artificial intelligence (AI) models into high-stakes domains such as healthcare and scientific research calls for models that are not only accurate but also interpretable. Among the…

Machine Learning · Computer Science 2025-10-23 Zhuo Cao , Xuan Zhao , Lena Krieger , Hanno Scharr , Ira Assent

This article studies the estimation of the causal effect of a time-varying treatment on time-to-an-event or on some other continuously distributed outcome. The paper applies to the situation where treatment is repeatedly adapted to…

Statistics Theory · Mathematics 2008-06-19 Judith J. Lok

We propose an interactive methodology for generating counterfactual explanations for univariate time series data in classification tasks by leveraging 2D projections and decision boundary maps to tackle interpretability challenges. Our…

Machine Learning · Computer Science 2024-08-21 Udo Schlegel , Julius Rauscher , Daniel A. Keim

Counterfactuals can explain classification decisions of neural networks in a human interpretable way. We propose a simple but effective method to generate such counterfactuals. More specifically, we perform a suitable diffeomorphic…

Machine Learning · Computer Science 2022-06-17 Ann-Kathrin Dombrowski , Jan E. Gerken , Klaus-Robert Müller , Pan Kessel

Deep generative models can emulate the perceptual properties of complex image datasets, providing a latent representation of the data. However, manipulating such representation to perform meaningful and controllable transformations in the…

Machine Learning · Computer Science 2019-12-13 Michel Besserve , Arash Mehrjou , Rémy Sun , Bernhard Schölkopf

Counterfactual explanations suggest what should be different in the input instance to change the outcome of an AI system. When dealing with counterfactual explanations in the field of Predictive Process Monitoring, however, control flow…

Artificial Intelligence · Computer Science 2025-08-26 Andrei Buliga , Chiara Di Francescomarino , Chiara Ghidini , Ivan Donadello , Fabrizio Maria Maggi

Data-driven decision making frequently relies on predicting counterfactual outcomes. In practice, researchers commonly train counterfactual prediction models on a source dataset to inform decisions on a possibly separate target population.…

Machine Learning · Statistics 2026-04-07 Keith Barnatchez , Kevin P. Josey , Rachel C. Nethery , Giovanni Parmigiani

Time series forecasting is crucial for many fields, such as disaster warning, weather prediction, and energy consumption. The Transformer-based models are considered to have revolutionized the field of sequence modeling. However, the…

Machine Learning · Computer Science 2022-11-01 Junlong Tong , Liping Xie , Wankou Yang , Kanjian Zhang

We describe Countersynth, a conditional generative model of diffeomorphic deformations that induce label-driven, biologically plausible changes in volumetric brain images. The model is intended to synthesise counterfactual training data…

Computer Vision and Pattern Recognition · Computer Science 2021-12-01 Guilherme Pombo , Robert Gray , Jorge Cardoso , Sebastien Ourselin , Geraint Rees , John Ashburner , Parashkev Nachev

Counterfactual learning has become promising for understanding and modeling causality in complex and dynamic systems. This paper presents a novel method for counterfactual learning in the context of multivariate time series analysis and…

Machine Learning · Computer Science 2026-03-03 Gianlucca Zuin , Adriano Veloso

Balanced representation learning methods have been applied successfully to counterfactual inference from observational data. However, approaches that account for survival outcomes are relatively limited. Survival data are frequently…

Machine Learning · Statistics 2021-03-04 Paidamoyo Chapfuwa , Serge Assaad , Shuxi Zeng , Michael J. Pencina , Lawrence Carin , Ricardo Henao

Diffusion models offer stable training and state-of-the-art performance for deep generative modeling tasks. Here, we consider their use in the context of multivariate subsurface modeling and probabilistic inversion. We first demonstrate…

Computer Vision and Pattern Recognition · Computer Science 2026-01-28 Roberto Miele , Niklas Linde

In this paper, we propose a new and unified approach for nonparametric regression and conditional distribution learning. Our approach simultaneously estimates a regression function and a conditional generator using a generative learning…

Machine Learning · Statistics 2023-06-28 Shanshan Song , Tong Wang , Guohao Shen , Yuanyuan Lin , Jian Huang

Wearable sensor data offer opportunities for personalized health monitoring, yet deriving actionable insights from their complex, longitudinal data streams is challenging. This paper introduces a framework to learn personalized…

Machine Learning · Computer Science 2025-08-21 Ajan Subramanian , Amir M. Rahmani

Counterfactual explanations provide individuals with cost-optimal recommendations to achieve their desired outcomes. However, when a significant number of individuals seek similar state modifications, this individual-centric approach can…

Machine Learning · Computer Science 2025-10-01 Ahmad-Reza Ehyaei , Ali Shirali , Samira Samadi

Counterfactual prediction methods are required when a model will be deployed in a setting where treatment policies differ from the setting where the model was developed, or when a model provides predictions under hypothetical interventions…

Methodology · Statistics 2025-08-13 Christopher B. Boyer , Issa J. Dahabreh , Jon A. Steingrimsson