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Rapid integration of large language models (LLMs) in health care is sparking global discussion about their potential to revolutionize health care quality and accessibility. At a time when improving health care quality and access remains a…

Although large language models (LLMs) often produce impressive outputs, it remains unclear how they perform in real-world scenarios requiring strong reasoning skills and expert domain knowledge. We set out to investigate whether close- and…

The proliferation of Large Language Models (LLMs) in high-stakes applications such as medical (self-)diagnosis and preliminary triage raises significant ethical and practical concerns about the effectiveness, appropriateness, and possible…

The disruptive technology provided by large-scale pre-trained language models (LLMs) such as ChatGPT or GPT-4 has received significant attention in several application domains, often with an emphasis on high-level opportunities and…

The primary aim of this research was to address the limitations observed in the medical knowledge of prevalent large language models (LLMs) such as ChatGPT, by creating a specialized language model with enhanced accuracy in medical advice.…

People are increasingly seeking healthcare information from large language models (LLMs) via interactive chatbots, yet the nature and inherent risks of these conversations remain largely unexplored. In this paper, we filter large-scale…

The rapid evolution of LLMs represents an impactful paradigm shift in digital interaction and content engagement. While they encode vast amounts of human-generated knowledge and excel in processing diverse data types, they often face the…

Millions of patients are already using large language model (LLM) chatbots for medical advice on a regular basis, raising patient safety concerns. This physician-led red-teaming study compares the safety of four publicly available…

Recent studies have demonstrated promising performance of ChatGPT and GPT-4 on several medical domain tasks. However, none have assessed its performance using a large-scale real-world electronic health record database, nor have evaluated…

Machine learning methods are increasingly applied to analyze health-related public discourse based on large-scale data, but questions remain regarding their ability to accurately detect different types of health sentiments. Especially,…

This study explores the application of Large Language Models (LLMs), specifically GPT-4, in the analysis of classroom dialogue, a crucial research task for both teaching diagnosis and quality improvement. Recognizing the knowledge-intensive…

Since the release of ChatGPT and GPT-4, large language models (LLMs) and multimodal large language models (MLLMs) have attracted widespread attention for their exceptional capabilities in understanding, reasoning, and generation,…

Pre-trained large language models(LLMs) have attracted increasing attention in biomedical domains due to their success in natural language processing. However, the complex traits and heterogeneity of multi-sources genomics data pose…

Large Language Models (LLMs) are transforming AI across industries, but their development and deployment remain complex. This survey reviews 16 key challenges in building and using LLMs and examines how these challenges are addressed by two…

Large language models (LLMs) have shown remarkable capabilities in various natural language tasks and are increasingly being applied in healthcare domains. This work demonstrates a new LLM-powered disease risk assessment approach via…

Large Language Models (LLMs), which simulate human users, are frequently employed to evaluate chatbots in applications such as tutoring and customer service. Effective evaluation necessitates a high degree of human-like diversity within…

Safety lies at the core of the development of Large Language Models (LLMs). There is ample work on aligning LLMs with human ethics and preferences, including data filtering in pretraining, supervised fine-tuning, reinforcement learning from…

Deploying Large Language Models (LLMs) for question answering (QA) over lengthy contexts is a significant challenge. In industrial settings, this process is often hindered by high computational costs and latency, especially when multiple…

Forecasting the short-term spread of an ongoing disease outbreak is a formidable challenge due to the complexity of contributing factors, some of which can be characterized through interlinked, multi-modality variables such as…

Large language models (LLMs) are a special class of pretrained language models obtained by scaling model size, pretraining corpus and computation. LLMs, because of their large size and pretraining on large volumes of text data, exhibit…