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Over the past few decades, neuroscience experiments have become increasingly complex and naturalistic. Experimental design has in turn become more challenging, as experiments must conform to an ever-increasing diversity of design…

Neurons and Cognition · Quantitative Biology 2020-12-07 Storm Slivkoff , Jack L. Gallant

We present an integrated prediction-optimization (PredOpt) framework to efficiently solve sequential decision-making problems by predicting the values of binary decision variables in an optimal solution. We address the key issues of…

Machine Learning · Computer Science 2023-11-14 Dogacan Yilmaz , İ. Esra Büyüktahtakın

Online prediction methods are typically presented as serial algorithms running on a single processor. However, in the age of web-scale prediction problems, it is increasingly common to encounter situations where a single processor cannot…

Machine Learning · Computer Science 2012-02-01 Ofer Dekel , Ran Gilad-Bachrach , Ohad Shamir , Lin Xiao

Designing faster algorithms for solving Mixed-Integer Linear Programming (MILP) problems is highly desired across numerous practical domains, as a vast array of complex real-world challenges can be effectively modeled as MILP formulations.…

Artificial Intelligence · Computer Science 2026-01-23 Ruizhi Liu , Liming Xu , Xulin Huang , Jingyan Sui , Shizhe Ding , Boyang Xia , Chungong Yu , Dongbo Bu

Basis path testing is a cornerstone of structural testing, yet traditional automated methods, relying on greedy graph-traversal algorithms (e.g., DFS/BFS), often generate sub-optimal paths. This structural inferiority is not a trivial…

Software Engineering · Computer Science 2026-01-12 Chao Wei , Xinyi Peng , Yawen Yan , Mao Luo , Ting Cai

Ensemble learning combines multiple classifiers in the hope of obtaining better predictive performance. Empirical studies have shown that ensemble pruning, that is, choosing an appropriate subset of the available classifiers, can lead to…

Large Neighborhood Search (LNS) is a combinatorial optimization heuristic that starts with an assignment of values for the variables to be optimized, and iteratively improves it by searching a large neighborhood around the current…

Optimization and Control · Mathematics 2022-05-23 Nicolas Sonnerat , Pengming Wang , Ira Ktena , Sergey Bartunov , Vinod Nair

Mixed-integer nonlinear programs (MINLPs) arise in domains such as energy systems, process engineering, and transportation, and are notoriously difficult to solve at scale due to the interplay of discrete decisions and nonlinear…

Machine Learning · Computer Science 2025-12-16 Bo Tang , Elias B. Khalil , Ján Drgoňa

This paper proposes a multi-step probabilistic forecasting framework using a single neural-network based model to generate simultaneous point and interval forecasts. Our approach ensures non-crossing prediction intervals (PIs) through a…

Machine Learning · Computer Science 2026-04-21 Worachit Amnuaypongsa , Yotsapat Suparanonrat , Pana Wanitchollakit , Jitkomut Songsiri

In this paper, we describe a comprehensive algorithmic framework for solving mixed integer bilevel linear optimization problems (MIBLPs) using a generalized branch-and-cut approach. The framework presented merges features from existing…

Optimization and Control · Mathematics 2021-04-20 Sahar Tahernejad , Ted K. Ralphs , Scott T. DeNegre

There has been a surge of interest in learning optimal decision trees using mixed-integer programs (MIP) in recent years, as heuristic-based methods do not guarantee optimality and find it challenging to incorporate constraints that are…

Machine Learning · Computer Science 2023-02-15 Shivaram Subramanian , Wei Sun

In this paper, we explore model-based approach to training robust and interpretable binarized regression models for multiclass classification tasks using Mixed-Integer Programming (MIP). Our MIP model balances the optimization of prediction…

Machine Learning · Computer Science 2022-03-22 Sanjana Tule , Nhi Ha Lan Le , Buser Say

Decision trees are a popular machine learning model which are traditionally trained by heuristic methods. Massive improvements in computing power and optimisation techniques has led to renewed interest in learning globally optimal decision…

Optimization and Control · Mathematics 2025-11-25 Mitchell Keegan , Michael Forbes , Paul Corry , Mahdi Abolghasemi

Mixed-integer programming (MIP) is a well-established framework for computer-aided molecular design (CAMD). By precisely encoding the molecular space and score functions, e.g., a graph neural network, the molecular design problem is…

Computational Engineering, Finance, and Science · Computer Science 2024-11-26 Shiqiang Zhang , Christian W. Feldmann , Frederik Sandfort , Miriam Mathea , Juan S. Campos , Ruth Misener

We consider online wireless network virtualization (WNV) in a multi-cell multiple-input multiple output (MIMO) system with delayed feedback of channel state information (CSI). Multiple service providers (SPs) simultaneously share the base…

Information Theory · Computer Science 2022-02-22 Juncheng Wang , Ben Liang , Min Dong , Gary Boudreau , Hatem Abou-zeid

Mixed-integer programming (MIP) extends linear programming by incorporating both continuous and integer decision variables, making it widely used in production planning, logistics scheduling, and resource allocation. However, MIP remains…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-14 Jinyu Zhang , Di Huang , Yue Liu , Shuo Wang , Zhenyu Pu , Zhiyuan Liu

With the abundance of available data, many enterprises seek to implement data-driven prescriptive analytics to help them make informed decisions. These prescriptive policies need to satisfy operational constraints, and proactively eliminate…

Optimization and Control · Mathematics 2022-07-22 Shivaram Subramanian , Wei Sun , Youssef Drissi , Markus Ettl

Mixed-Integer Linear Programs (MIPs) are powerful and flexible tools for modeling a wide range of real-world combinatorial optimization problems. Predict-and-Search methods operate by using a predictive model to estimate promising variable…

Artificial Intelligence · Computer Science 2026-04-21 Junyang Cai , El Mehdi Er Raqabi , Pascal Van Hentenryck , Bistra Dilkina

Mixed-integer optimization solvers often find optimal solutions early in the search, yet spend the majority of computation time proving optimality. We exploit this by learning when to terminate solvers early on distributions of similar…

Optimization and Control · Mathematics 2026-02-03 Stefan Clarke , Bartolomeo Stellato

Recent work has shown potential in using Mixed Integer Programming (MIP) solvers to optimize certain aspects of neural networks (NNs). However the intriguing approach of training NNs with MIP solvers is under-explored.…

Machine Learning · Computer Science 2023-04-03 Tómas Thorbjarnarson , Neil Yorke-Smith
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