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Supervised learning tasks such as cancer survival prediction from gigapixel whole slide images (WSIs) are a critical challenge in computational pathology that requires modeling complex features of the tumor microenvironment. These learning…

Image and Video Processing · Electrical Eng. & Systems 2022-11-22 Iain Carmichael , Andrew H. Song , Richard J. Chen , Drew F. K. Williamson , Tiffany Y. Chen , Faisal Mahmood

Multiple instance learning (MIL) is concerned with learning from sets (bags) of objects (instances), where the individual instance labels are ambiguous. In this setting, supervised learning cannot be applied directly. Often, specialized MIL…

Machine Learning · Statistics 2014-12-04 Veronika Cheplygina , David M. J. Tax , Marco Loog

Area under the receiver operating characteristics curve (AUC) is an important metric for a wide range of signal processing and machine learning problems, and scalable methods for optimizing AUC have recently been proposed. However, handling…

Machine Learning · Computer Science 2018-06-01 San Gultekin , Avishek Saha , Adwait Ratnaparkhi , John Paisley

Multiple instance learning (MIL) stands as a powerful approach in weakly supervised learning, regularly employed in histological whole slide image (WSI) classification for detecting tumorous lesions. However, existing mainstream MIL methods…

Image and Video Processing · Electrical Eng. & Systems 2024-07-08 Wenhui Zhu , Xiwen Chen , Peijie Qiu , Aristeidis Sotiras , Abolfazl Razi , Yalin Wang

We propose a novel pooling strategy that learns how to adaptively rank deep convolutional features for selecting more informative representations. To this end, we exploit discriminative analysis to project the features onto a space spanned…

Machine Learning · Computer Science 2017-10-23 Arash Shahriari , Fatih Porikli

Real-world large-scale medical image analysis (MIA) datasets have three challenges: 1) they contain noisy-labelled samples that affect training convergence and generalisation, 2) they usually have an imbalanced distribution of samples per…

Computer Vision and Pattern Recognition · Computer Science 2022-08-23 Fengbei Liu , Yuanhong Chen , Yu Tian , Yuyuan Liu , Chong Wang , Vasileios Belagiannis , Gustavo Carneiro

Stochastic gradient descent-based algorithms are widely used for training deep neural networks but often suffer from slow convergence. To address the challenge, we leverage the framework of the alternating direction method of multipliers…

Machine Learning · Computer Science 2025-02-03 Ouya Wang , Shenglong Zhou , Geoffrey Ye Li

Multiple Instance Learning (MIL) is a popular weakly-supervised method for various applications, with a particular interest in histological whole slide image (WSI) classification. Due to the gigapixel resolution of WSI, applications of MIL…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Wenhui Zhu , Peijie Qiu , Xiwen Chen , Zhangsihao Yang , Aristeidis Sotiras , Abolfazl Razi , Yalin Wang

This paper presents a weakly supervised image segmentation method that adopts tight bounding box annotations. It proposes generalized multiple instance learning (MIL) and smooth maximum approximation to integrate the bounding box tightness…

Computer Vision and Pattern Recognition · Computer Science 2021-10-25 Juan Wang , Bin Xia

Compute-in-memory (CIM) is an efficient method for implementing deep neural networks (DNNs) but suffers from substantial overhead from analog-to-digital converters (ADCs), especially as ADC precision increases. Low-precision ADCs can reduce…

Hardware Architecture · Computer Science 2025-03-14 Jiyoon Kim , Kang Eun Jeon , Yulhwa Kim , Jong Hwan Ko

Multi-instance learning (MIL) deals with tasks where data is represented by a set of bags and each bag is described by a set of instances. Unlike standard supervised learning, only the bag labels are observed whereas the label for each…

Machine Learning · Computer Science 2021-04-27 Weijia Zhang , Jiuyong Li , Lin Liu

As the size of modern data sets exceeds the disk and memory capacities of a single computer, machine learning practitioners have resorted to parallel and distributed computing. Given that optimization is one of the pillars of machine…

Machine Learning · Statistics 2017-04-18 Alexandros Nathan , Diego Klabjan

In many real-world tasks, particularly those involving data objects with complicated semantics such as images and texts, one object can be represented by multiple instances and simultaneously be associated with multiple labels. Such tasks…

Machine Learning · Computer Science 2020-07-07 Sheng-Jun Huang , Zhi-Hua Zhou

Weakly supervised instance segmentation (WSIS) using only image-level labels is a challenging task due to the difficulty of aligning coarse annotations with the finer task. However, with the advancement of deep neural networks (DNNs), WSIS…

Computer Vision and Pattern Recognition · Computer Science 2024-02-13 Zecheng Li , Zening Zeng , Yuqi Liang , Jin-Gang Yu

Fine-tuning pretrained language models (PLMs) for downstream tasks is a large-scale optimization problem, in which the choice of the training algorithm critically determines how well the trained model can generalize to unseen test data,…

Machine Learning · Computer Science 2023-10-27 Guangliang Liu , Zhiyu Xue , Xitong Zhang , Kristen Marie Johnson , Rongrong Wang

Machine learning models have become integral to many fields, but their reliability, defined as producing dependable, trustworthy, and domain-consistent predictions, remains a critical concern. Multiple Instance Learning (MIL) models…

Computer Vision and Pattern Recognition · Computer Science 2025-12-10 Hassan Keshvarikhojasteh , Marc Aubreville , Christof A. Bertram , Josien P. W. Pluim , Mitko Veta

A central goal in deep learning is to learn compact representations of features at every layer of a neural network, which is useful for both unsupervised representation learning and structured network pruning. While there is a growing body…

Machine Learning · Computer Science 2021-10-05 Jie Bu , Arka Daw , M. Maruf , Anuj Karpatne

Whole slide image (WSI) assessment is a challenging and crucial step in cancer diagnosis and treatment planning. WSIs require high magnifications to facilitate sub-cellular analysis. Precise annotations for patch- or even pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2023-11-20 Simon Holdenried-Krafft , Peter Somers , Ivonne A. Montes-Majarro , Diana Silimon , Cristina Tarín , Falko Fend , Hendrik P. A. Lensch

Multi-instance partial-label learning (MIPL) is an emerging learning framework where each training sample is represented as a multi-instance bag associated with a candidate label set. Existing MIPL algorithms often overlook the margins for…

Machine Learning · Computer Science 2025-01-23 Wei Tang , Yin-Fang Yang , Zhaofei Wang , Weijia Zhang , Min-Ling Zhang

We address the challenging problem of whole slide image (WSI) classification. WSIs have very high resolutions and usually lack localized annotations. WSI classification can be cast as a multiple instance learning (MIL) problem when only…

Computer Vision and Pattern Recognition · Computer Science 2021-04-05 Bin Li , Yin Li , Kevin W. Eliceiri
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