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Deep neural networks have introduced significant advancements in the field of machine learning-based analysis of digital pathology images including prostate tissue images. With the help of transfer learning, classification and segmentation…

Post-hoc attribution methods aim to explain deep learning predictions by highlighting influential input pixels. However, these explanations are highly non-robust: small, imperceptible input perturbations can drastically alter the…

Machine Learning · Computer Science 2025-06-19 Alaa Anani , Tobias Lorenz , Mario Fritz , Bernt Schiele

Saliency methods are widely used to interpret neural network predictions, but different variants of saliency methods often disagree even on the interpretations of the same prediction made by the same model. In these cases, how do we…

Computation and Language · Computer Science 2021-04-14 Shuoyang Ding , Philipp Koehn

Understanding how deep neural networks make decisions is crucial for analyzing their behavior and diagnosing failure cases. In computer vision, a common approach to improve interpretability is to assign importance to individual pixels using…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Kagan Ozturk , Aman Bhatta , Haiyu Wu , Patrick Flynn , Kevin W. Bowyer

Deep learning models have achieved remarkable success across various domains, yet their learned representations and decision-making processes remain largely opaque and hard to interpret. This work introduces HOLE (Homological Observation of…

Machine Learning · Computer Science 2026-04-08 Sudhanva Manjunath Athreya , Paul Rosen

Recent developments in machine learning have introduced models that approach human performance at the cost of increased architectural complexity. Efforts to make the rationales behind the models' predictions transparent have inspired an…

Computation and Language · Computer Science 2020-09-29 Pepa Atanasova , Jakob Grue Simonsen , Christina Lioma , Isabelle Augenstein

Deep neural networks are starting to show their worth in critical applications such as assisted cancer diagnosis. However, for their outputs to get accepted in practice, the results they provide should be explainable in a way easily…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Martin Krebs , Jan Obdržálek , Vít Musil , Tomáš Brázdil

Although deep reinforcement learning has become a promising machine learning approach for sequential decision-making problems, it is still not mature enough for high-stake domains such as autonomous driving or medical applications. In such…

Machine Learning · Computer Science 2022-02-25 Claire Glanois , Paul Weng , Matthieu Zimmer , Dong Li , Tianpei Yang , Jianye Hao , Wulong Liu

An important part of breast cancer staging is the assessment of the sentinel axillary node for early signs of tumor spreading. However, this assessment by pathologists is not always easy and retrospective surveys often requalify the status…

Quantitative Methods · Quantitative Biology 2024-04-30 Eric Bonnet

Convolutional neural networks (CNNs) have shown exceptional performance for a range of medical imaging tasks. However, conventional CNNs are not able to explain their reasoning process, therefore limiting their adoption in clinical…

Computer Vision and Pattern Recognition · Computer Science 2022-08-02 Linde S. Hesse , Ana I. L. Namburete

Deep neural networks are very successful on many vision tasks, but hard to interpret due to their black box nature. To overcome this, various post-hoc attribution methods have been proposed to identify image regions most influential to the…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Sukrut Rao , Moritz Böhle , Bernt Schiele

Accurate diagnosis of breast cancer in histopathology images is challenging due to the heterogeneity of cancer cell growth as well as of a variety of benign breast tissue proliferative lesions. In this paper, we propose a practical and…

Computer Vision and Pattern Recognition · Computer Science 2020-05-06 Xingyu Li , Marko Radulovic , Ksenija Kanjer , Konstantinos N. Plataniotis

A major challenge in Explainable AI is in correctly interpreting activations of hidden neurons: accurate interpretations would help answer the question of what a deep learning system internally detects as relevant in the input, demystifying…

Artificial Intelligence · Computer Science 2026-02-23 Abhilekha Dalal , Rushrukh Rayan , Adrita Barua , Eugene Y. Vasserman , Md Kamruzzaman Sarker , Pascal Hitzler

Despite the tremendous achievements of deep convolutional neural networks (CNNs) in many computer vision tasks, understanding how they actually work remains a significant challenge. In this paper, we propose a novel two-step understanding…

Computer Vision and Pattern Recognition · Computer Science 2019-04-02 Heyi Li , Yunke Tian , Klaus Mueller , Xin Chen

Convolutional neural networks (CNNs) have been recently used for a variety of histology image analysis. However, availability of a large dataset is a major prerequisite for training a CNN which limits its use by the computational pathology…

Computer Vision and Pattern Recognition · Computer Science 2018-03-07 Ruqayya Awan , Navid Alemi Koohbanani , Muhammad Shaban , Anna Lisowska , Nasir Rajpoot

Deep models based on vision transformer (ViT) and convolutional neural network (CNN) have demonstrated remarkable performance on natural datasets. However, these models may not be similar in medical imaging, where abnormal regions cover…

Computer Vision and Pattern Recognition · Computer Science 2026-02-11 Ahmad Chaddad , Yihang Wu , Xianrui Chen

This position paper defends post-hoc explainability methods as legitimate tools for scientific knowledge production in machine learning. Addressing criticism of these methods' reliability and epistemic status, we develop a philosophical…

Machine Learning · Computer Science 2025-10-31 Nick Oh

Deep learning methods are widely used for medical applications to assist medical doctors in their daily routines. While performances reach expert's level, interpretability (highlight how and what a trained model learned and why it makes a…

Computer Vision and Pattern Recognition · Computer Science 2020-09-30 Antoine Pirovano , Hippolyte Heuberger , Sylvain Berlemont , Saïd Ladjal , Isabelle Bloch

Deep neural networks that yield human interpretable decisions by architectural design have lately become an increasingly popular alternative to post hoc interpretation of traditional black-box models. Among these networks, the arguably most…

Computer Vision and Pattern Recognition · Computer Science 2021-06-24 Adrian Hoffmann , Claudio Fanconi , Rahul Rade , Jonas Kohler

Deep neural networks for medical image classification often fail to generalize consistently in clinical practice due to violations of the i.i.d. assumption and opaque decision-making. This paper examines interpretability in deep neural…

Computer Vision and Pattern Recognition · Computer Science 2025-04-09 Mohammad Hossein Najafi , Mohammad Morsali , Mohammadreza Pashanejad , Saman Soleimani Roudi , Mohammad Norouzi , Saeed Bagheri Shouraki
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