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Modeling viral dynamics in HIV/AIDS studies has resulted in a deep understanding of pathogenesis of HIV infection from which novel antiviral treatment guidance and strategies have been derived. Viral dynamics models based on nonlinear…

Applications · Statistics 2010-10-08 Hua Liang , Hongyu Miao , Hulin Wu

Instrumental variable (IV) methods are central to causal inference from observational data, particularly when a randomized experiment is not feasible. However, of the three conventional core IV identification conditions, only one, IV…

Methodology · Statistics 2025-09-23 Zhonghua Liu , Baoluo Sun , Ting Ye , David Richardson , Eric Tchetgen Tchetgen

The increasing availability of experimental data has intensified interest in calibrating stochastic models, raising fundamental questions about parameter identifiability. Structural identifiability determines whether parameters can be…

Methodology · Statistics 2026-05-14 Arianna Ceccarelli , Alexander P. Browning , Ruth E. Baker

We consider a dynamic method, based on synchronization and adaptive control, to estimate unknown parameters of a nonlinear dynamical system from a given scalar chaotic time series. We present an important extension of the method when time…

Chaotic Dynamics · Physics 2009-10-31 Anil Maybhate , R. E. Amritkar

We study identifiability of the parameters in autoregressions defined on a network. Most identification conditions that are available for these models either rely on the network being observed repeatedly, are only sufficient, or require…

Econometrics · Economics 2022-06-06 Federico Martellosio

Machine learning (ML) and deep learning models are extensively used for parameter optimization and regression problems. However, not all inverse problems in ML are ``identifiable,'' indicating that model parameters may not be uniquely…

Machine Learning · Computer Science 2023-07-24 Reza Sameni

Given a collection of features available for inclusion in a predictive model, it may be of interest to quantify the relative importance of a subset of features for the prediction task at hand. For example, in HIV vaccine trials, participant…

Methodology · Statistics 2025-03-27 Charles J. Wolock , Peter B. Gilbert , Noah Simon , Marco Carone

We address the issue of the testability of instrumental variables derived from observational data. Most existing testable implications are centered on scenarios where the treatment is a discrete variable, e.g., instrumental inequality…

Methodology · Statistics 2026-03-13 Xichen Guo , Zheng Li , Biwei Huang , Yan Zeng , Zhi Geng , Feng Xie

This paper studies linear time-invariant descriptor systems which are not necessarily regular. We introduce the notion of partial detectability and characterize this concept by means of a simple rank criterion involving the system…

Optimization and Control · Mathematics 2023-01-25 Juhi Jaiswal , Thomas Berger , Nutan Kumar Tomar

This erratum highlights a very serious error in a paper published by SIAM Review in 2011. The error is in Section 6.2 of [1]. It is very important to notify this error because of the following two reasons: (i) [1] is one of the most cited…

Optimization and Control · Mathematics 2024-03-26 Agostino Martinelli

Identifiability is a desirable property of a statistical model: it implies that the true model parameters may be estimated to any desired precision, given sufficient computational resources and data. We study identifiability in the context…

Machine Learning · Statistics 2020-07-09 Geoffrey Roeder , Luke Metz , Diederik P. Kingma

Researchers develop models to explain the unknowns. These models typically involve parameters that capture tangible quantities, the estimation of which is desired. Parameter identifiability investigates the recoverability of the unknown…

Optimization and Control · Mathematics 2024-07-01 Anuththara Sarathchandra , Azadeh Aghaeeyan , Pouria Ramazi

The identifiability analysis of linear Ordinary Differential Equation (ODE) systems is a necessary prerequisite for making reliable causal inferences about these systems. While identifiability has been well studied in scenarios where the…

Machine Learning · Statistics 2024-10-31 Yuanyuan Wang , Biwei Huang , Wei Huang , Xi Geng , Mingming Gong

We study causal representation learning, the task of inferring latent causal variables and their causal relations from high-dimensional mixtures of the variables. Prior work relies on weak supervision, in the form of counterfactual pre- and…

Dynamical systems, for instance in model predictive control, often contain unknown parameters, which must be determined during system operation. Online or on-the-fly parameter identification methods are therefore necessary. The challenge of…

Optimization and Control · Mathematics 2021-04-05 Barbara Kaltenbacher , Tram Thi Ngoc Nguyen

Identifiability is the property in mathematical modelling that determines if model parameters can be uniquely estimated from data. For infectious disease models, failure to ensure identifiability can lead to misleading parameter estimates…

Methodology · Statistics 2025-06-10 Fanny Bergström , Martina Favero , Tom Britton

It is hard to identify nonlinear biological models strictly from data, with results that are often sensitive to experimental conditions. Automated experimental workflows and liquid handling enables unprecedented throughput, as well as the…

Dynamical Systems · Mathematics 2019-09-17 Nibodh Boddupalli , Aqib Hasnain , Sai Pushpak Nandanoori , Enoch Yeung

This paper considers the problem of identifying the parameters of an uncertain linear system by means of feedback control. The problem is approached by considering time-varying controllers. It is shown that even when the uncertainty set is…

Systems and Control · Computer Science 2015-04-17 G. Battistelli , P. Tesi

Structural identifiability is an important property of parametric ODE models. When conducting an experiment and inferring the parameter value from the time-series data, we want to know if the value is globally, locally, or non-identifiable.…

Discrete Mathematics · Computer Science 2024-06-25 Natali Gogishvili

Non-stationary systems are found throughout the world, from climate patterns under the influence of variation in carbon dioxide concentration, to brain dynamics driven by ascending neuromodulation. Accordingly, there is a need for methods…

Data Analysis, Statistics and Probability · Physics 2024-07-15 Kieran S. Owens , Ben D. Fulcher