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Alcohol misuse is a key target of public health strategies aimed at reducing cardiovascular risk. The effect of excessive alcohol consumption on blood pressure may vary systematically with individuals' unobserved propensity to engage in…

Methodology · Statistics 2026-03-11 Ashish Patel , Francis J DiTraglia , Stephen Burgess

In pharmacoepidemiology research, instrumental variables (IVs) are variables that strongly predict treatment but have no causal effect on the outcome of interest except through the treatment. There remain concerns about the inclusion of IVs…

Missing values are common in real-world time series, and multivariate time series forecasting with missing values (MTSF-M) has become a crucial area of research for ensuring reliable predictions. To address the challenge of missing data,…

Machine Learning · Computer Science 2026-02-03 Jie Yang , Yifan Hu , Kexin Zhang , Luyang Niu , Philip S. Yu , Kaize Ding

Outstanding achievements of graph neural networks for spatiotemporal time series analysis show that relational constraints introduce an effective inductive bias into neural forecasting architectures. Often, however, the relational…

Machine Learning · Computer Science 2023-08-03 Andrea Cini , Daniele Zambon , Cesare Alippi

The role of epidemiological models is crucial for informing public health officials during a public health emergency, such as the COVID-19 pandemic. However, traditional epidemiological models fail to capture the time-varying effects of…

Methodology · Statistics 2022-06-17 Adam Spannaus , Theodore Papamarkou , Samantha Erwin , J. Blair Christian

To reduce the complexity of infrared spectroscopy hardware while maintaining performance, a data informed, task-specific, spectral collection approach termed Sparse Infrared Spectroscopy (SIRS) is developed. Using a numerically based…

Chemical Physics · Physics 2025-06-27 Mira Welner , Andre Hazbun , Thomas Beechem

Latent variables often mask cause-effect relationships in observational data which provokes spurious links that may be misinterpreted as causal. This problem sparks great interest in the fields such as climate science and economics. We…

Machine Learning · Computer Science 2022-11-21 Violeta Teodora Trifunov , Maha Shadaydeh , Joachim Denzler

Instrumental variable (IV) methods are widely used to infer treatment effects in the presence of unmeasured confounding. In this paper, we study nonparametric inference with an IV under a separable binary treatment choice model, which…

Methodology · Statistics 2026-02-03 Chan Park , Eric Tchetgen Tchetgen

Mendelian randomization is an instrumental variable method that utilizes genetic information to investigate the causal effect of a modifiable exposure on an outcome. In most cases, the exposure changes over time. Understanding the…

Methodology · Statistics 2024-03-11 Haodong Tian , Ashish Patel , Stephen Burgess

With the increased availability of large databases of electronic health records (EHRs) comes the chance of enhancing health risks screening. Most post-marketing detections of adverse drug reaction (ADR) rely on physicians' spontaneous…

Applications · Statistics 2018-01-29 Maryan Morel , Emmanuel Bacry , Stéphane Gaïffas , Agathe Guilloux , Fanny Leroy

As a popular tool for producing meaningful and interpretable models, large-scale sparse learning works efficiently when the underlying structures are indeed or close to sparse. However, naively applying the existing regularization methods…

Methodology · Statistics 2017-10-10 Zemin Zheng , Jinchi Lv , Wei Lin

People with Type 1 diabetes (T1D) require regular exogenous infusion of insulin to maintain their blood glucose concentration in a therapeutically adequate target range. Although the artificial pancreas and continuous glucose monitoring…

Signal Processing · Electrical Eng. & Systems 2020-09-08 Taiyu Zhu , Kezhi Li , Pau Herrero , Pantelis Georgiou

Identifying variables responsible for changes to a biological system enables applications in drug target discovery and cell engineering. Given a pair of observational and interventional datasets, the goal is to isolate the subset of…

Machine Learning · Computer Science 2025-06-02 Menghua Wu , Umesh Padia , Sean H. Murphy , Regina Barzilay , Tommi Jaakkola

Insulin resistance (IR) is a key precursor to diabetes and a significant risk factor for cardiovascular disease. Traditional IR assessment methods require multiple blood tests. We developed a simple AI model using only fasting blood glucose…

Machine Learning · Computer Science 2025-03-10 Weihao Gao , Zhuo Deng , Zheng Gong , Ziyi Jiang , Lan Ma

In the presence of grouped covariates, we propose a framework for boosting that allows to enforce sparsity within and between groups. By using component-wise and group-wise gradient boosting at the same time with adjusted degrees of…

Methodology · Statistics 2024-04-09 Fabian Obster , Christian Heumann

Instrumental variables (IVs) are crucial for addressing unobservable confounders, yet their stringent exogeneity assumptions pose significant challenges in networked data. Existing methods typically rely on modelling neighbour information…

Artificial Intelligence · Computer Science 2026-02-10 Zhirong Huang , Debo Cheng , Guixian Zhang , Yi Wang , Jiuyong Li , Shichao Zhang

Sparse autoencoders (SAEs) improve interpretability in multimodal models, but it remains unclear whether SAE features form modular, composable units for reasoning-an assumption underlying many intervention-based steering methods. We test…

Artificial Intelligence · Computer Science 2026-03-27 Yunpeng Zhou

At the heart of causal structure learning from observational data lies a deceivingly simple question: given two statistically dependent random variables, which one has a causal effect on the other? This is impossible to answer using…

Machine Learning · Computer Science 2020-10-13 Nikolaos Nikolaou , Konstantinos Sechidis

This paper describes an approach to simultaneously identify clusters and estimate cluster-specific regression parameters from the given data. Such an approach can be useful in learning the relationship between input and output when the…

Statistical Finance · Quantitative Finance 2024-01-02 Udai Nagpal , Krishan Nagpal

Causality lays the foundation for the trajectory of our world. Causal inference (CI), which aims to infer intrinsic causal relations among variables of interest, has emerged as a crucial research topic. Nevertheless, the lack of observation…

Machine Learning · Computer Science 2024-06-21 Yaochen Zhu , Yinhan He , Jing Ma , Mengxuan Hu , Sheng Li , Jundong Li
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