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Missing data in time series is a pervasive problem that puts obstacles in the way of advanced analysis. A popular solution is imputation, where the fundamental challenge is to determine what values should be filled in. This paper proposes…

Machine Learning · Computer Science 2023-07-06 Wenjie Du , David Cote , Yan Liu

We present a comprehensive analysis of deep learning approaches for Electronic Health Record (EHR) time-series imputation, examining how architectural and framework biases combine to influence model performance. Our investigation reveals…

Machine Learning · Computer Science 2025-02-05 Linglong Qian , Tao Wang , Jun Wang , Hugh Logan Ellis , Robin Mitra , Richard Dobson , Zina Ibrahim

Analyzing the health status of patients based on Electronic Health Records (EHR) is a fundamental research problem in medical informatics. The presence of extensive missing values in EHR makes it challenging for deep neural networks (DNNs)…

Machine Learning · Computer Science 2025-03-14 Weibin Liao , Yinghao Zhu , Zhongji Zhang , Yuhang Wang , Zixiang Wang , Xu Chu , Yasha Wang , Liantao Ma

Missing values in multivariate time series data can harm machine learning performance and introduce bias. These gaps arise from sensor malfunctions, blackouts, and human error and are typically addressed by data imputation. Previous work…

Machine Learning · Computer Science 2025-03-04 Mohammad Rafid Ul Islam , Prasad Tadepalli , Alan Fern

Missing data is a significant problem impacting all domains. State-of-the-art framework for minimizing missing data bias is multiple imputation, for which the choice of an imputation model remains nontrivial. We propose a multiple…

Machine Learning · Computer Science 2018-02-20 Lovedeep Gondara , Ke Wang

Regular medical records are useful for medical practitioners to analyze and monitor patient health status especially for those with chronic disease, but such records are usually incomplete due to unpunctuality and absence of patients. In…

Causal inference is fundamental to empirical scientific discoveries in natural and social sciences; however, in the process of conducting causal inference, data management problems can lead to false discoveries. Two such problems are (i)…

Databases · Computer Science 2023-05-16 Brit Youngmann , Michael Cafarella , Babak Salimi , Anna Zeng

Electronic health records (EHR) often contain varying levels of missing data. This study compared different imputation strategies to identify the most suitable approach for predicting central line-associated bloodstream infection (CLABSI)…

Multiple imputation has become one of the standard methods in drawing inferences in many incomplete data applications. Applications of multiple imputation in relatively more complex settings, such as high-dimensional clustered data, require…

Methodology · Statistics 2025-04-08 Qiushuang Li , Recai Yucel

Missing data is a common problem in clinical data collection, which causes difficulty in the statistical analysis of such data. In this article, we consider the problem under a framework of a semiparametric partially linear model when…

Methodology · Statistics 2022-06-13 Zishu Zhan , Xiangjie Li , Jingxiao Zhang

Handling missing data in time series is a complex problem due to the presence of temporal dependence. General-purpose imputation methods, while widely used, often distort key statistical properties of the data, such as variance and…

Methodology · Statistics 2026-03-18 Guilherme Pumi , Taiane Schaedler Prass , Douglas Krauthein Verdum

Missing values of varying patterns and rates in real-world tabular data pose a significant challenge in developing reliable data-driven models. The most commonly used statistical and machine learning methods for missing value imputation may…

Machine Learning · Computer Science 2025-03-26 Ibna Kowsar , Shourav B. Rabbani , Yina Hou , Manar D. Samad

Targeted Maximum Likelihood Estimation (TMLE) is increasingly used for doubly robust causal inference, but how missing data should be handled when using TMLE with data-adaptive approaches is unclear. Based on the Victorian Adolescent Health…

Missing data is a pervasive issue in statistical analyses, affecting the reliability and validity of research across diverse scientific disciplines. Failure to adequately address missing data can lead to biased estimates and consequently…

Methodology · Statistics 2025-05-06 Asmaa Ahmad , Eric J Rose , Michael Roy , Edward Valachovic

Medical time series datasets feature missing values that need data imputation methods, however, conventional machine learning models fall short due to a lack of uncertainty quantification in predictions. Among these models, the CATSI…

Machine Learning · Computer Science 2024-10-07 Omkar Kulkarni , Rohitash Chandra

Three-level data structures arising from repeated measures on individuals clustered within larger units are common in health research studies. Missing data are prominent in such studies and are often handled via multiple imputation (MI).…

Sensor data has been playing an important role in machine learning tasks, complementary to the human-annotated data that is usually rather costly. However, due to systematic or accidental mis-operations, sensor data comes very often with a…

Machine Learning · Computer Science 2017-11-22 Jingguang Zhou , Zili Huang

Imputing missing values in multivariate time series remains challenging, especially under diverse missing patterns and heavy missingness. Existing methods suffer from suboptimal performance as corrupted temporal features hinder effective…

Machine Learning · Computer Science 2026-04-07 Dongik Park , Hyunwoo Ryu , Suahn Bae , Keondo Park , Hyung-Sin Kim

Missing values or data is one popular characteristic of real-world datasets, especially healthcare data. This could be frustrating when using machine learning algorithms on such datasets, simply because most machine learning models perform…

Machine Learning · Computer Science 2024-03-25 Luke Oluwaseye Joel , Wesley Doorsamy , Babu Sena Paul

Externally controlled trials (ECTs) compare outcomes between a single-arm trial and external controls drawn from sources such as historical trials, registries, or observational studies. In survival analysis, a major challenge arises when…

Methodology · Statistics 2025-09-18 Q. Le Coent , G. L. Rosner , M-C. Wang , C. Hu
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