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Inherently interpretable machine learning (IML) models offer valuable support for clinical decision-making but face challenges when features contain missing values. Traditional approaches, such as imputation or discarding incomplete…

Machine Learning · Computer Science 2025-02-12 Lena Stempfle , Arthur James , Julie Josse , Tobias Gauss , Fredrik D. Johansson

This article introduces the Python package gcimpute for missing data imputation. gcimpute can impute missing data with many different variable types, including continuous, binary, ordinal, count, and truncated values, by modeling data as…

Methodology · Statistics 2022-03-11 Yuxuan Zhao , Madeleine Udell

Return-to-baseline is an important method to impute missing values or unobserved potential outcomes when certain hypothetical strategies are used to handle intercurrent events in clinical trials. Current return-to-baseline approaches seen…

Methodology · Statistics 2021-11-19 Yongming Qu , Biyue Dai

Missing data are often dealt with multiple imputation. A crucial part of the multiple imputation process is selecting sensible models to generate plausible values for incomplete data. A method based on posterior predictive checking is…

Computation · Statistics 2026-05-14 Mingyang Cai , Stef van Buuren , Gerko Vink

In clinical trials, mixed effects models for repeated measures (MMRM) and pattern mixture models (PMM) are often used to analyze longitudinal continuous outcomes. We describe a simple missing data imputation algorithm for the MMRM that can…

Methodology · Statistics 2016-10-13 Yongqiang Tang

The Time Since Infection (TSI) models, which use disease surveillance data to model infectious diseases, have become increasingly popular due to their flexibility and capacity to address complex disease control questions. However, a notable…

Methodology · Statistics 2025-01-10 Jiasheng Shi , Yizhao Zhou , Jing Huang

We develop a novel doubly-robust (DR) imputation framework for longitudinal studies with monotone dropout, motivated by the informative dropout that is common in FDA-regulated trials for Alzheimer's disease. In this approach, the missing…

Methodology · Statistics 2023-05-05 Yuqi Qiu , Karen Messer

We present a simple yet novel time series imputation technique with the goal of constructing an irregular time series that is uniform across every sample in a data set. Specifically, we fix a grid defined by the midpoints of non-overlapping…

Machine Learning · Computer Science 2022-01-19 Andrew Baumgartner , Sevda Molani , Qi Wei , Jennifer Hadlock

Multiple imputation (MI) is a technique especially designed for handling missing data in public-use datasets. It allows analysts to perform incomplete-data inference straightforwardly by using several already imputed datasets released by…

Methodology · Statistics 2022-01-03 Kin Wai Chan

A foundational challenge in uncertainty quantification involves estimating a probability measure on the space of uncertain parameters such that its push-forward through a computational model matches an observed probability measure on the…

Optimization and Control · Mathematics 2026-04-21 Tianyi Jiang , Troy Butler , Timothy Wildey , Tim Kutta , Haonan Wang

Multiple imputation is a straightforward method for handling missing data in a principled fashion. This paper presents an overview of multiple imputation, including important theoretical results and their practical implications for…

Methodology · Statistics 2018-01-15 Jared S. Murray

A large fraction of the electronic health records (EHRs) consists of clinical measurements collected over time, such as lab tests and vital signs, which provide important information about a patient's health status. These sequences of…

Machine Learning · Statistics 2020-03-02 Karl Øyvind Mikalsen , Cristina Soguero-Ruiz , Robert Jenssen

Combining match scores from different biometric systems via fusion is a well-established approach to improving recognition accuracy. However, missing scores can degrade performance as well as limit the possible fusion techniques that can be…

Computer Vision and Pattern Recognition · Computer Science 2024-08-16 Melissa R Dale , Elliot Singer , Bengt J. Borgström , Arun Ross

Existing methods to characterise the evolving condition of traumatic brain injury (TBI) patients in the intensive care unit (ICU) do not capture the context necessary for individualising treatment. Here, we integrate all heterogenous data…

Electronic patient records (EPRs) produce a wealth of data but contain significant missing information. Understanding and handling this missing data is an important part of clinical data analysis and if left unaddressed could result in bias…

Machine Learning · Computer Science 2024-02-12 Neslihan Suzen , Evgeny M. Mirkes , Damian Roland , Jeremy Levesley , Alexander N. Gorban , Tim J. Coats

Missing data are ubiquitous in the era of big data and, if inadequately handled, are known to lead to biased findings and have deleterious impact on data-driven decision makings. To mitigate its impact, many missing value imputation methods…

Machine Learning · Computer Science 2021-10-26 Yiliang Zhang , Qi Long

Multivariate time series alignment is critical for ensuring coherent analysis across variables, but missing values and timestamp inconsistencies make this task highly challenging. Existing approaches often rely on prior imputation, which…

Databases · Computer Science 2025-12-23 Ding Jia , Jingyu Zhu , Yu Sun , Aoqian Zhang , Shaoxu Song , Haiwei Zhang , Xiaojie Yuan

We propose tensor time series imputation when the missing pattern in the tensor data can be general, as long as any two data positions along a tensor fibre are both observed for enough time points. The method is based on a tensor time…

Statistics Theory · Mathematics 2024-09-17 Zetai Cen , Clifford Lam

Irregular multivariate time series with missing values present significant challenges for predictive modeling in domains such as healthcare. While deep learning approaches often focus on temporal interpolation or complex architectures to…

Machine Learning · Computer Science 2026-03-16 Dingyi Nie , Yixing Wu , C. -C. Jay Kuo

A cornerstone of the worldwide transition to smart grids are smart meters. Smart meters typically collect and provide energy time series that are vital for various applications, such as grid simulations, fault-detection, load forecasting,…

Machine Learning · Computer Science 2021-08-11 Moritz Weber , Marian Turowski , Hüseyin K. Çakmak , Ralf Mikut , Uwe Kühnapfel , Veit Hagenmeyer
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