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Discovering novel catalysts requires complex reasoning involving multiple chemical properties and resultant trade-offs, leading to a combinatorial growth in the search space. While large language models (LLM) have demonstrated novel…

Artificial Intelligence · Computer Science 2023-11-07 Henry W. Sprueill , Carl Edwards , Mariefel V. Olarte , Udishnu Sanyal , Heng Ji , Sutanay Choudhury

Accurate prediction of the physicochemical properties of molecular mixtures using graph neural networks remains a significant challenge, as it requires simultaneous embedding of intramolecular interactions while accounting for mixture…

Chemical Physics · Physics 2026-03-04 Jinming Fan , Chao Qian , Wilhelm T. S. Huck , William E. Robinson , Shaodong Zhou

This paper presents a Large Language Model (LLM) based conversational agent system designed to enhance human-machine collaboration in Machine Learning Operations (MLOps). We introduce the Swarm Agent, an extensible architecture that…

Artificial Intelligence · Computer Science 2025-11-11 George Fatouros , Georgios Makridis , George Kousiouris , John Soldatos , Anargyros Tsadimas , Dimosthenis Kyriazis

Molecular property prediction and generative design via deep learning models has been the subject of intense research given its potential to accelerate development of new, high-performance materials. More recently, these workflows have been…

Artificial Intelligence · Computer Science 2024-12-16 Nathaniel H. Park , Tiffany J. Callahan , James L. Hedrick , Tim Erdmann , Sara Capponi

Large language models (LLMs) have demonstrated remarkable potential in solving complex tasks across diverse domains, typically by employing agentic workflows that follow detailed instructions and operational sequences. However, constructing…

We use prompt engineering to guide ChatGPT in the automation of text mining of metal-organic frameworks (MOFs) synthesis conditions from diverse formats and styles of the scientific literature. This effectively mitigates ChatGPT's tendency…

Information Retrieval · Computer Science 2023-10-04 Zhiling Zheng , Oufan Zhang , Christian Borgs , Jennifer T. Chayes , Omar M. Yaghi

Recent advancements in Large Language Models (LLMs) have spurred interest in deploying LLM agents to undertake tasks in the world. LLMs are often deployed in agent systems: code that orchestrates LLM calls and provides them with tools. We…

Artificial Intelligence · Computer Science 2025-05-20 Maxime Robeyns , Martin Szummer , Laurence Aitchison

The emergence of agent-based systems represents a significant advancement in artificial intelligence, with growing applications in automated data extraction. However, chemical information extraction remains a formidable challenge due to the…

Large Language Models (LLMs) stand at the forefront of a number of Natural Language Processing (NLP) tasks. Despite the widespread adoption of LLMs in NLP, much of their potential in broader fields remains largely unexplored, and…

Machine Learning · Computer Science 2024-03-11 Zhiqiang Zhong , Kuangyu Zhou , Davide Mottin

The increasing complexity of computer science research projects demands more effective tools for deploying code repositories. Large Language Models (LLMs), such as Anthropic Claude and Meta Llama, have demonstrated significant advancements…

Software Engineering · Computer Science 2025-02-13 Yijia Xiao , Runhui Wang , Luyang Kong , Davor Golac , Wei Wang

Since the introduction of the Model Context Protocol (MCP), the number of available tools for Large Language Models (LLMs) has increased significantly. These task-specific tool sets offer an alternative to general-purpose tools such as web…

Computation and Language · Computer Science 2025-12-12 Reza Esfandiarpoor , Vishwas Suryanarayanan , Stephen H. Bach , Vishal Chowdhary , Anthony Aue

The rapid advancement of large language models (LLMs) has created a diverse landscape of models, each excelling at different tasks. This diversity drives researchers to employ multiple LLMs in practice, leaving behind valuable multi-LLM log…

Machine Learning · Computer Science 2025-09-30 Tao Feng , Haozhen Zhang , Zijie Lei , Pengrui Han , Mostofa Patwary , Mohammad Shoeybi , Bryan Catanzaro , Jiaxuan You

The rapid evolution of large language models (LLMs) is transforming artificial intelligence into autonomous research partners, yet a critical gap persists in complex scientific domains such as combustion modeling. Here, practical AI…

Machine Learning · Computer Science 2026-01-06 Ke Xiao , Haoze Zhang , Runze Mao , Han Li , Zhi X. Chen

Large language models (LLMs) have been touted to enable increased productivity in many areas of today's work life. Scientific research as an area of work is no exception: the potential of LLM-based tools to assist in the daily work of…

Software Engineering · Computer Science 2024-04-24 Mohamed Nejjar , Luca Zacharias , Fabian Stiehle , Ingo Weber

Literature review requires researchers to synthesize a large amount of information and is increasingly challenging as the scientific literature expands. In this work, we investigate the potential of LLMs for producing hierarchical…

Computation and Language · Computer Science 2024-07-24 Chao-Chun Hsu , Erin Bransom , Jenna Sparks , Bailey Kuehl , Chenhao Tan , David Wadden , Lucy Lu Wang , Aakanksha Naik

Providing personalized assistance at scale is a long-standing challenge for computing educators, but a new generation of tools powered by large language models (LLMs) offers immense promise. Such tools can, in theory, provide on-demand help…

Computers and Society · Computer Science 2024-01-09 Brad Sheese , Mark Liffiton , Jaromir Savelka , Paul Denny

Molecular Relational Learning (MRL) aims to understand interactions between molecular pairs, playing a critical role in advancing biochemical research. With the recent development of large language models (LLMs), a growing number of studies…

Machine Learning · Computer Science 2025-06-03 Zhuo Chen , Yizhen Zheng , Huan Yee Koh , Hongxin Xiang , Linjiang Chen , Wenjie Du , Yang Wang

Molecular editing-modifying a given molecule to improve desired properties-is a fundamental task in drug discovery. While LLMs hold the potential to solve this task using natural language to drive the editing, straightforward prompting…

Machine Learning · Computer Science 2026-02-10 Khiem Le , Ting Hua , Nitesh V. Chawla

Large language model (LLM) agents rely on external tools to solve complex tasks, but real-world toolsets often contain redundant tools with overlapping names and descriptions, introducing ambiguity and reducing selection accuracy. LLMs also…

Computation and Language · Computer Science 2026-05-12 Marianne Menglin Liu , Daniel Garcia , Fjona Parllaku , Vikas Upadhyay , Syed Fahad Allam Shah , Dan Roth

Finetuning a Large Language Model (LLM) is crucial for generating results towards specific objectives. This research delves into the realm of drug optimization and introduce a novel reinforcement learning algorithm to finetune a drug…

Machine Learning · Computer Science 2025-02-12 Xuefeng Liu , Songhao Jiang , Siyu Chen , Zhuoran Yang , Yuxin Chen , Ian Foster , Rick Stevens
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