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Generative modeling of peptide sequences requires navigating a discrete and highly constrained space in which many intermediate states are chemically implausible or unstable. Existing discrete diffusion and flow-based methods rely on…

Biomolecules · Quantitative Biology 2026-02-02 Shrey Goel , Pranam Chatterjee

In this work, we revisit the discrete-time Schr\"{o}dinger Bridge (SB) and Density Steering (DS) problems for Gaussian mixture model (GMM) boundary distributions. Building on the existing literature, we construct a set of feasible Markovian…

Systems and Control · Electrical Eng. & Systems 2026-04-02 George Rapakoulias , Fengjiao Liu , Panagiotis Tsiotras

Schr\"odinger bridge (SB) has emerged as the go-to method for optimizing transportation plans in diffusion models. However, SB requires estimating the intractable forward score functions, inevitably resulting in the costly implicit training…

Machine Learning · Computer Science 2025-05-27 Wei Deng , Weijian Luo , Yixin Tan , Marin Biloš , Yu Chen , Yuriy Nevmyvaka , Ricky T. Q. Chen

We survey continuous-time generative modeling methods based on transporting a simple reference distribution to a data distribution via stochastic or deterministic dynamics. We present a unified framework in which diffusion models,…

Machine Learning · Computer Science 2026-05-11 Aditya Ranganath , Mukesh Singhal

We study Diffusion Schr\"odinger Bridge (DSB) models in the context of dynamical astrophysical systems, specifically tackling observational inverse prediction tasks within Giant Molecular Clouds (GMCs) for star formation. We introduce the…

Instrumentation and Methods for Astrophysics · Physics 2025-11-13 Ye Zhu , Duo Xu , Zhiwei Deng , Jonathan C. Tan , Olga Russakovsky

We consider the problem to identify the most likely flow in phase space, of (inertial) particles under stochastic forcing, that is in agreement with spatial (marginal) distributions that are specified at a set of points in time. The…

Optimization and Control · Mathematics 2019-02-25 Yongxin Chen , Giovanni Conforti , Tryphon T. Georgiou , Luigia Ripani

Solving inverse problems -- recovering signals from incomplete or noisy measurements -- is fundamental in science and engineering. Score-based generative models (SGMs) have recently emerged as a powerful framework for this task. Two main…

Machine Learning · Computer Science 2025-10-27 Bartlomiej Sobieski , Matthew Tivnan , Yuang Wang , Siyeop Yoon , Pengfei Jin , Dufan Wu , Quanzheng Li , Przemyslaw Biecek

There has been a recent surge in learning generative models for graphs. While impressive progress has been made on static graphs, work on generative modeling of temporal graphs is at a nascent stage with significant scope for improvement.…

Machine Learning · Computer Science 2022-08-26 Shubham Gupta , Sahil Manchanda , Srikanta Bedathur , Sayan Ranu

A Schr\"{o}dinger bridge establishes a dynamic transport map between two target distributions via a reference process, simultaneously solving an associated entropic optimal transport problem. We consider the setting where samples from the…

Machine Learning · Computer Science 2025-01-22 Stefano Peluchetti

Population dynamics is the study of temporal and spatial variation in the size of populations of organisms and is a major part of population ecology. One of the main difficulties in analyzing population dynamics is that we can only obtain…

Machine Learning · Computer Science 2023-02-28 Takeshi Koshizuka , Issei Sato

Modern distribution matching algorithms for training diffusion or flow models directly prescribe the time evolution of the marginal distributions between two boundary distributions. In this work, we consider a generalized distribution…

Scientists often want to make predictions beyond the observed time horizon of "snapshot" data following latent stochastic dynamics. For example, in time course single-cell mRNA profiling, scientists have access to cellular transcriptional…

Machine Learning · Statistics 2025-05-23 Renato Berlinghieri , Yunyi Shen , Jialong Jiang , Tamara Broderick

We explore whether useful temporal neural generative models can be learned from sequential data without back-propagation through time. We investigate the viability of a more neurocognitively-grounded approach in the context of unsupervised…

Machine Learning · Computer Science 2017-12-01 Alexander G. Ororbia , Patrick Haffner , David Reitter , C. Lee Giles

Generative models for images have gained significant attention in computer vision and natural language processing due to their ability to generate realistic samples from complex data distributions. To leverage the advances of image-based…

Machine Learning · Computer Science 2023-09-01 Justin Hellermann , Stefan Lessmann

Temporal link prediction in dynamic graphs is a fundamental problem in many real-world systems. Existing temporal graph neural networks mainly focus on learning representations of historical interactions. Despite their strong performance,…

Machine Learning · Computer Science 2026-02-02 Nguyen Minh Duc , Viet Cuong Ta

Inferring cellular trajectories from destructive snapshots is complicated by the challenges of stochasticity and non-conservative mass dynamics such as cell proliferation and apoptosis. Existing unbalanced Optimal Transport (OT) methods…

Machine Learning · Computer Science 2026-05-04 Junda Ying , Yuxuan Wang , Bowen Yang , Peijie Zhou , Lei Zhang

The Schr\"odinger bridge problem is concerned with finding a stochastic dynamical system bridging two marginal distributions that minimises a certain transportation cost. This problem, which represents a generalisation of optimal transport…

Machine Learning · Computer Science 2026-03-03 Kirill Tamogashev , Nikolay Malkin

Mass transport problems arise in many areas of machine learning whereby one wants to compute a map transporting one distribution to another. Generative modeling techniques like Generative Adversarial Networks (GANs) and Denoising Diffusion…

Machine Learning · Computer Science 2024-09-17 Valentin De Bortoli , Iryna Korshunova , Andriy Mnih , Arnaud Doucet

Consider a reference Markov process with initial distribution $\pi_{0}$ and transition kernels $\{M_{t}\}_{t\in[1:T]}$, for some $T\in\mathbb{N}$. Assume that you are given distribution $\pi_{T}$, which is not equal to the marginal…

Computation · Statistics 2020-01-01 Espen Bernton , Jeremy Heng , Arnaud Doucet , Pierre E. Jacob

In image generation, Schr\"odinger Bridge (SB)-based methods theoretically enhance the efficiency and quality compared to the diffusion models by finding the least costly path between two distributions. However, they are computationally…

Computer Vision and Pattern Recognition · Computer Science 2025-03-05 Xingyu Qiu , Mengying Yang , Xinghua Ma , Fanding Li , Dong Liang , Gongning Luo , Wei Wang , Kuanquan Wang , Shuo Li