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We develop a simple model of ionic current through neuronal membranes as a function of membrane potential and extracellular ion concentration. The model combines a simplified Poisson-Nernst-Planck (PNP) model of ion transport through…

Biological Physics · Physics 2023-09-06 Linda Werneck , Mertcan Han , Erdost Yildiz , Marc-André Keip , Metin Sitti , Michael Ortiz

In this article we propose and investigate a hierarchy of mathematical models based on partial differential equations (PDE) and ordinary differential equations (ODE) for the simulation of the biophysical phenomena occurring in the…

Numerical Analysis · Mathematics 2016-01-20 Emanuela Abbate , Matteo Porro , Thierry Nieus , Riccardo Sacco

A new computational method is presented for study suspensions of charged soft particles undergoing fluctuating hydrodynamic and electrostatic interactions. The proposed model is appropriate for polymers, proteins and porous particles…

Soft Condensed Matter · Physics 2015-04-14 Juan P. Hernandez-Ortiz , Juan J. de Pablo

We present two dimensional (2D) particle-in-cell (PIC) simulations of 2D Bernstein-Greene-Kruskal (BGK) modes, which are exact nonlinear steady-state solutions of the Vlasov-Poisson equations, on a 2D plane perpendicular to a background…

Plasma Physics · Physics 2024-04-09 J. McClung , M. T. Franciscovich , K. Germaschewski , C. S. Ng

First-order energy dissipative schemes in time are available in literature for the Poisson-Nernst-Planck (PNP) equations, but second-order ones are still in lack. This work proposes novel second-order discretization in time and finite…

Numerical Analysis · Mathematics 2023-09-08 Jie Ding , Shenggao Zhou

An efficient surface integral equation-based method is proposed for the analysis of electromagnetic scattering from multilayered media containing complex periodic inclusions. The proposed method defines equivalent currents at the interfaces…

Optics · Physics 2014-08-19 Nilufer A. Ozdemir , Christophe Craeye

A model of a finite cylindrical ion channel through a phospholipid membrane of width $L$ separating two electrolyte reservoirs is studied. Analytical solution of the Poisson equation is obtained for an arbitrary distribution of ions inside…

Soft Condensed Matter · Physics 2009-11-11 Yan Levin

The Poisson-Boltzmann equation offers an efficient way to study electrostatics in molecular settings. Its numerical solution with the boundary element method is widely used, as the complicated molecular surface is accurately represented by…

Numerical Analysis · Mathematics 2021-08-25 Stefan D. Search , Christopher D. Cooper , Elwin van't Wout

In this paper, based on geometric singular perturbation analysis of a quasi-one dimensional Poisson-Nernst-Planck model for ionic flows, we study the problem of zero current condition for ionic flows through membrane channels with a simple…

Dynamical Systems · Mathematics 2020-09-22 Hamid Mofidi , Weishi Liu

The Poisson-Nernst-Planck (PNP) equations are one of the most effective model for describing electrostatic interactions and diffusion processes in ion solution systems, and have been widely used in the numerical simulations of biological…

Numerical Analysis · Mathematics 2023-12-19 Yang Liu , Shi Shu , Ying Yang

Effects of the adsorption-desorption process on the immittance response of an electrolytic cell are theoretically investigated in the framework of the diffusional Poisson-Nernst-Planck (PNP) continuum model, when the generation and…

This paper presents a general high-order kernel regularization technique applicable to all four integral operators of Calder\'on calculus associated with linear elliptic PDEs in two and three spatial dimensions. Like previous density…

Numerical Analysis · Mathematics 2021-03-02 Luiz M. Faria , Carlos Pérez-Arancibia , Marc Bonnet

In this paper, we introduce and analyze a class of numerical schemes that demonstrate remarkable superiority in terms of efficiency, the preservation of positivity, energy stability, and high-order precision to solve the time-dependent…

Numerical Analysis · Mathematics 2025-07-01 Waixiang Cao , Yuzhe Qin , Minqiang Xu

The ion distribution around charged colloids in solution has been investigated intensely during the last decade. However, few theoretical approaches have included the influence of variation in the dielectric permittivity within the system,…

Soft Condensed Matter · Physics 2015-06-18 Florian Fahrenberger , Zhenli Xu , Christian Holm

We present a 3D finite element solver for the nonlinear Poisson-Nernst-Planck (PNP) equations for electrodiffusion, coupled to the Stokes system of fluid dynamics. The model serves as a building block for the simulation of macromolecule…

Computational Physics · Physics 2017-04-05 Gregor Mitscha-Baude , Andreas Buttinger-Kreuzhuber , Gerhard Tulzer , Clemens Heitzinger

A path integral Monte Carlo method (PIMC) based on Feynman-Kac formula for mixed boundary conditions of elliptic equations is proposed to solve the forward problem of electrical impedance tomography (EIT) on the boundary to obtain…

Numerical Analysis · Mathematics 2019-08-01 Yijing Zhou , Wei Cai

We develop a boundary integral equation-based numerical method to solve for the electrostatic potential in two dimensions, inside a medium with piecewise constant conductivity, where the boundary condition is given by the complete electrode…

Numerical Analysis · Mathematics 2024-03-28 Teemu Tyni , Adam R Stinchcombe , Spyros Alexakis

We study the geometric particle-in-cell methods for an electrostatic hybrid plasma model. In this model, ions are described by the fully kinetic equations, electron density is determined by the Boltzmann relation, and space-charge effects…

Numerical Analysis · Mathematics 2026-03-26 Yingzhe Li

Ion transport, the movement of ions across a cellular membrane, plays a crucial role in a wide variety of biological processes and can be described by the Poisson-Nernst-Planck equations with steric effects (PNP-steric equations). In this…

Analysis of PDEs · Mathematics 2019-07-16 Li-Chang Hung , Mach Nguyet Minh

In this paper, we solve the linearized Poisson-Boltzmann equation, used to model the electric potential of macromolecules in a solvent. We derive a corrected trapezoidal rule with improved accuracy for a boundary integral formulation of the…

Numerical Analysis · Mathematics 2022-10-10 Federico Izzo , Yimin Zhong , Olof Runborg , Richard Tsai