A Simple Quantitative Model of Neuromodulation. Part I: Ion Flow Through Neural Ion Channels
Abstract
We develop a simple model of ionic current through neuronal membranes as a function of membrane potential and extracellular ion concentration. The model combines a simplified Poisson-Nernst-Planck (PNP) model of ion transport through individual mechanosensitive ion channels with channel activation functions calibrated from ad hoc in-house experimental data. The simplified PNP model is validated against bacterial Gramicidin A ion channel data. The calibrated model accounts for the transport of calcium, sodium, potassium, and chloride and exhibits remarkable agreement with the experimentally measured current-voltage curves for the differentiated human neural cells. All relevant data and code related to the ion flow models are available at DaRUS.
Keywords
Cite
@article{arxiv.2309.01393,
title = {A Simple Quantitative Model of Neuromodulation. Part I: Ion Flow Through Neural Ion Channels},
author = {Linda Werneck and Mertcan Han and Erdost Yildiz and Marc-André Keip and Metin Sitti and Michael Ortiz},
journal= {arXiv preprint arXiv:2309.01393},
year = {2023}
}
Comments
17 pages, 8 figures