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Multiple instance learning (MIL) was a weakly supervised learning approach that sought to assign binary class labels to collections of instances known as bags. However, due to their weak supervision nature, the MIL methods were susceptible…

Computer Vision and Pattern Recognition · Computer Science 2024-05-27 Wenhui Zhu , Peijie Qiu , Xiwen Chen , Oana M. Dumitrascu , Yalin Wang

Recent deep learning methods for object detection rely on a large amount of bounding box annotations. Collecting these annotations is laborious and costly, yet supervised models do not generalize well when testing on images from a different…

Computer Vision and Pattern Recognition · Computer Science 2019-10-25 Han-Kai Hsu , Chun-Han Yao , Yi-Hsuan Tsai , Wei-Chih Hung , Hung-Yu Tseng , Maneesh Singh , Ming-Hsuan Yang

To learn target discriminative representations, using pseudo-labels is a simple yet effective approach for unsupervised domain adaptation. However, the existence of false pseudo-labels, which may have a detrimental influence on learning…

Computer Vision and Pattern Recognition · Computer Science 2019-08-02 Jaehoon Choi , Minki Jeong , Taekyung Kim , Changick Kim

Automated skin lesion analysis is very crucial in clinical practice, as skin cancer is among the most common human malignancy. Existing approaches with deep learning have achieved remarkable performance on this challenging task, however,…

Computer Vision and Pattern Recognition · Computer Science 2019-09-06 Xueying Shi , Qi Dou , Cheng Xue , Jing Qin , Hao Chen , Pheng-Ann Heng

Pathology image classification plays a crucial role in accurate medical diagnosis and treatment planning. Training high-performance models for this task typically requires large-scale annotated datasets, which are both expensive and…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Lanfeng Zhong , Xin Liao , Shichuan Zhang , Shaoting Zhang , Guotai Wang

Deep learning for medical image classification faces three major challenges: 1) the number of annotated medical images for training are usually small; 2) regions of interest (ROIs) are relatively small with unclear boundaries in the whole…

Computer Vision and Pattern Recognition · Computer Science 2019-10-23 Shaohua Li , Yong Liu , Xiuchao Sui , Cheng Chen , Gabriel Tjio , Daniel Shu Wei Ting , Rick Siow Mong Goh

Cancer diagnosis has greatly benefited from the integration of whole-slide images (WSIs) with multiple instance learning (MIL), enabling high-resolution analysis of tissue morphology. Graph-based MIL (GNN-MIL) approaches have emerged as…

Computer Vision and Pattern Recognition · Computer Science 2025-08-27 Jongwoo Kim , Bryan Wong , Huazhu Fu , Willmer Rafell Quiñones , Youngsin Ko , Mun Yong Yi

Multiple Instance Learning (MIL) is a cornerstone approach in computational pathology (CPath) for generating clinically meaningful slide-level embeddings from gigapixel tissue images. However, MIL often struggles with small, weakly…

Computer Vision and Pattern Recognition · Computer Science 2025-06-12 Daniel Shao , Richard J. Chen , Andrew H. Song , Joel Runevic , Ming Y. Lu , Tong Ding , Faisal Mahmood

Small sample instance segmentation is a very challenging task, and many existing methods follow the training strategy of meta-learning which pre-train models on support set and fine-tune on query set. The pre-training phase, which is highly…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Ruting Chi , Zhiyi Huang , Yuexing Han

Accurate gross tumor volume segmentation on multi-modal medical data is critical for radiotherapy planning in nasopharyngeal carcinoma and glioblastoma. Recent advances in deep neural networks have brought promising results in medical image…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Jingyun Yang , Guoqing Zhang , Jingge Wang , Yang Li

Pixel-wise segmentation is one of the most data and annotation hungry tasks in our field. Providing representative and accurate annotations is often mission-critical especially for challenging medical applications. In this paper, we propose…

Computer Vision and Pattern Recognition · Computer Science 2021-04-28 Simon Reiß , Constantin Seibold , Alexander Freytag , Erik Rodner , Rainer Stiefelhagen

Deep learning-based methods are gaining traction in digital pathology, with an increasing number of publications and challenges that aim at easing the work of systematically and exhaustively analyzing tissue slides. These methods often…

Image and Video Processing · Electrical Eng. & Systems 2020-06-25 Ting-An Yen , Hung-Chun Hsu , Pushpak Pati , Maria Gabrani , Antonio Foncubierta-Rodríguez , Pau-Choo Chung

The rapidly emerging field of computational pathology has the potential to enable objective diagnosis, therapeutic response prediction and identification of new morphological features of clinical relevance. However, deep learning-based…

Image and Video Processing · Electrical Eng. & Systems 2020-05-25 Ming Y. Lu , Drew F. K. Williamson , Tiffany Y. Chen , Richard J. Chen , Matteo Barbieri , Faisal Mahmood

Self-training approach recently secures its position in domain adaptive semantic segmentation, where a model is trained with target domain pseudo-labels. Current advances have mitigated noisy pseudo-labels resulting from the domain gap.…

Computer Vision and Pattern Recognition · Computer Science 2023-08-14 Dongyu Yao , Boheng Li

Compared with multi-class classification, multi-label classification that contains more than one class is more suitable in real life scenarios. Obtaining fully labeled high-quality datasets for multi-label classification problems, however,…

Computer Vision and Pattern Recognition · Computer Science 2022-10-26 Xin Zhang , Rabab Abdelfattah , Yuqi Song , Xiaofeng Wang

We propose a novel scalable end-to-end pipeline that uses symbolic domain knowledge as constraints for learning a neural network for classifying unlabeled data in a weak-supervised manner. Our approach is particularly well-suited for…

Machine Learning · Computer Science 2023-10-23 Sudhir Agarwal , Anu Sreepathy , Lalla Mouatadid

Multi-instance learning (MIL) deals with objects represented as bags of instances and can predict instance labels from bag-level supervision. However, significant performance gaps exist between instance-level MIL algorithms and supervised…

Machine Learning · Computer Science 2022-10-06 Weijia Zhang , Xuanhui Zhang , Han-Wen Deng , Min-Ling Zhang

Domain shift is a significant challenge in machine learning, particularly in medical applications where data distributions differ across institutions due to variations in data collection practices, equipment, and procedures. This can…

Machine Learning · Computer Science 2025-06-30 Takumi Okuo , Shinnosuke Matsuo , Shota Harada , Kiyohito Tanaka , Ryoma Bise

Automatic medical image segmentation plays a critical role in scientific research and medical care. Existing high-performance deep learning methods typically rely on large training datasets with high-quality manual annotations, which are…

Image and Video Processing · Electrical Eng. & Systems 2021-11-17 Shanshan Wang , Cheng Li , Rongpin Wang , Zaiyi Liu , Meiyun Wang , Hongna Tan , Yaping Wu , Xinfeng Liu , Hui Sun , Rui Yang , Xin Liu , Jie Chen , Huihui Zhou , Ismail Ben Ayed , Hairong Zheng

Multiple Instance Learning (MIL) methods allow for gigapixel Whole-Slide Image (WSI) analysis with only slide-level annotations. Interpretability is crucial for safely deploying such algorithms in high-stakes medical domains. Traditional…

Computer Vision and Pattern Recognition · Computer Science 2025-01-07 Susu Sun , Leslie Tessier , Frédérique Meeuwsen , Clément Grisi , Dominique van Midden , Geert Litjens , Christian F. Baumgartner