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Convolutional neural networks can be trained to perform histology slide classification using weak annotations with multiple instance learning (MIL). However, given the paucity of labeled histology data, direct application of MIL can easily…

Computer Vision and Pattern Recognition · Computer Science 2019-11-05 Ming Y. Lu , Richard J. Chen , Jingwen Wang , Debora Dillon , Faisal Mahmood

Whole-slide image classification represents a key challenge in computational pathology and medicine. Attention-based multiple instance learning (MIL) has emerged as an effective approach for this problem. However, the effect of attention…

Quantitative Methods · Quantitative Biology 2025-03-14 Rajiv Krishnakumar , Julien Baglio , Frederik F. Flöther , Christian Ruiz , Stefan Habringer , Nicole H. Romano

The work discusses the use of machine learning algorithms for anomaly detection in medical image analysis and how the performance of these algorithms depends on the number of annotators and the quality of labels. To address the issue of…

Computer Vision and Pattern Recognition · Computer Science 2023-03-30 Hieu H. Pham , Khiem H. Le , Tuan V. Tran , Ha Q. Nguyen

Multiple instance learning (MIL) has emerged as a popular method for classifying histopathology whole slide images (WSIs). Existing approaches typically rely on frozen pre-trained models to extract instance features, neglecting the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-20 Yi Lin , Zhengjie Zhu , Kwang-Ting Cheng , Hao Chen

We address the problem of \emph{instance label stability} in multiple instance learning (MIL) classifiers. These classifiers are trained only on globally annotated images (bags), but often can provide fine-grained annotations for image…

Computer Vision and Pattern Recognition · Computer Science 2017-03-16 Veronika Cheplygina , Lauge Sørensen , David M. J. Tax , Marleen de Bruijne , Marco Loog

Various multi-instance learning (MIL) based approaches have been developed and successfully applied to whole-slide pathological images (WSI). Existing MIL methods emphasize the importance of feature aggregators, but largely neglect the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Yicheng Song , Tiancheng Lin , Die Peng , Su Yang , Yi Xu

Automated disease diagnosis using medical image analysis relies on deep learning, often requiring large labeled datasets for supervised model training. Diseases like Acute Myeloid Leukemia (AML) pose challenges due to scarce and costly…

Computer Vision and Pattern Recognition · Computer Science 2024-08-26 Salome Kazeminia , Max Joosten , Dragan Bosnacki , Carsten Marr

Multiple Instance Learning (MIL) is a weakly-supervised problem in which one label is assigned to the whole bag of instances. An important class of MIL models is instance-based, where we first classify instances and then aggregate those…

Image and Video Processing · Electrical Eng. & Systems 2024-03-13 Łukasz Struski , Dawid Rymarczyk , Arkadiusz Lewicki , Robert Sabiniewicz , Jacek Tabor , Bartosz Zieliński

The vast majority of semantic segmentation approaches rely on pixel-level annotations that are tedious and time consuming to obtain and suffer from significant inter and intra-expert variability. To address these issues, recent approaches…

Training high-quality instance segmentation models requires an abundance of labeled images with instance masks and classifications, which is often expensive to procure. Active learning addresses this challenge by striving for optimum…

Computer Vision and Pattern Recognition · Computer Science 2023-09-29 Ke Yu , Stephen Albro , Giulia DeSalvo , Suraj Kothawade , Abdullah Rashwan , Sasan Tavakkol , Kayhan Batmanghelich , Xiaoqi Yin

Multiple instance learning (MIL) is a variation of traditional supervised learning problems where data (referred to as bags) are composed of sub-elements (referred to as instances) and only bag labels are available. MIL has a variety of…

Machine Learning · Computer Science 2018-05-02 Han Bao , Tomoya Sakai , Issei Sato , Masashi Sugiyama

Annotation cost is a bottleneck for collecting massive data in mammography, especially for training deep neural networks. In this paper, we study the use of heterogeneous levels of annotation granularity to improve predictive performances.…

Image and Video Processing · Electrical Eng. & Systems 2019-09-13 Thi-Lam-Thuy Le , Nicolas Thome , Sylvain Bernard , Vincent Bismuth , Fanny Patoureaux

Whole body magnetic resonance imaging (WB-MRI) is the recommended modality for diagnosis of multiple myeloma (MM). WB-MRI is used to detect sites of disease across the entire skeletal system, but it requires significant expertise and is…

While huge volumes of unlabeled data are generated and made available in many domains, the demand for automated understanding of visual data is higher than ever before. Most existing machine learning models typically rely on massive amounts…

Computer Vision and Pattern Recognition · Computer Science 2021-12-14 Youshan Zhang

Cell detection in histopathology images is of great value in clinical practice. \textit{Convolutional neural networks} (CNNs) have been applied to cell detection to improve the detection accuracy, where cell annotations are required for…

Computer Vision and Pattern Recognition · Computer Science 2021-07-01 Zipei Zhao , Fengqian Pang , Zhiwen Liu , Chuyang Ye

The success of deep convolutional neural networks (DCNNs) benefits from high volumes of annotated data. However, annotating medical images is laborious, expensive, and requires human expertise, which induces the label scarcity problem.…

Image and Video Processing · Electrical Eng. & Systems 2022-03-24 Ziyuan Zhao , Kaixin Xu , Shumeng Li , Zeng Zeng , Cuntai Guan

Domain adaptation (DA) is transfer learning which aims to learn an effective predictor on target data from source data despite data distribution mismatch between source and target. We present in this paper a novel unsupervised DA method for…

Computer Vision and Pattern Recognition · Computer Science 2018-02-23 Lingkun Luo , Liming Chen , Ying lu , Shiqiang Hu

Multi-instance learning (MIL) is a form of weakly supervised learning where a single class label is assigned to a bag of instances while the instance-level labels are not available. Training classifiers to accurately determine the bag label…

Computer Vision and Pattern Recognition · Computer Science 2020-06-11 Bin Li , Kevin W. Eliceiri

Labeling data for classification requires significant human effort. To reduce labeling cost, instead of labeling every instance, a group of instances (bag) is labeled by a single bag label. Computer algorithms are then used to infer the…

Machine Learning · Statistics 2014-11-18 Anh T. Pham , Raviv Raich , Xiaoli Z. Fern

The application of AI in oncology has been limited by its reliance on large, annotated datasets and the need for retraining models for domain-specific diagnostic tasks. Taking heed of these limitations, we investigated in-context learning…

Image and Video Processing · Electrical Eng. & Systems 2025-05-15 Mobina Shrestha , Bishwas Mandal , Vishal Mandal , Asis Shrestha