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Functional connectivity (FC) refers to the investigation of interactions between brain regions to understand integration of neural activity in several regions. FC is often estimated using functional magnetic resonance images (fMRI). There…

Applications · Statistics 2023-01-24 Nathan Tung , Jerome Sanes , Eli Upfal , Ani Eloyan

Spontaneous brain activity generically displays transient spatiotemporal coherent structures, which can selectively be affected in various neurological and psychiatric pathologies. Here we model the full brain's electroencephalographic…

Neurons and Cognition · Quantitative Biology 2025-02-25 Annalisa Caligiuri , David Papo , Görsev Yener , Bahar Güntekin , Tobias Galla , Lucas Lacasa , Massimiliano Zanin

Brain connectivity analysis is crucial for understanding brain structure and neurological function, shedding light on the mechanisms of mental illness. To study the association between individual brain connectivity networks and the clinical…

We present a novel method for quantifying the microscopic structure of brain tissue. It is based on the automated recognition of interpretable features obtained by analyzing the shapes of cells. This contrasts with prevailing methods of…

Computer Vision and Pattern Recognition · Computer Science 2024-04-10 Kui Qian , Litao Qiao , Beth Friedman , Edward O'Donnell , David Kleinfeld , Yoav Freund

Early brain development is characterized by the formation of a highly organized structural connectome. The interconnected nature of this connectome underlies the brain's cognitive abilities and influences its response to diseases and…

Neurons and Cognition · Quantitative Biology 2023-08-24 Yihan Wu , Lana Vasung , Camilo Calixto , Ali Gholipour , Davood Karimi

The application of machine learning algorithms to the diagnosis and analysis of Alzheimer's disease (AD) from multimodal neuroimaging data is a current research hotspot. It remains a formidable challenge to learn brain region information…

Image and Video Processing · Electrical Eng. & Systems 2022-08-11 Yongcheng Zong , Changhong Jing , Qiankun Zuo

Brain network analysis is a useful approach to studying human brain disorders because it can distinguish patients from healthy people by detecting abnormal connections. Due to the complementary information from multiple modal neuroimages,…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Qiankun Zuo , Yanfei Zhu , Libin Lu , Zhi Yang , Yuhui Li , Ning Zhang

Understanding the dynamic reorganization of brain networks is critical for predicting cognitive decline, neurological progression, and individual variability in clinical outcomes. This work proposes a multimodal graph neural network…

Machine Learning · Computer Science 2026-02-11 Preksha Girish , Rachana Mysore , Kiran K. N. , Hiranmayee R. , Shipra Prashanth , Shrey Kumar

The spatial topography of functional brain organization is increasingly recognized to play an important role in cognition and disease. Accounting for individual differences in functional topography is also crucial for accurately…

Accurately modeling longitudinal brain MRI progression is crucial for understanding neurodegenerative diseases and predicting individualized structural changes. Existing state-of-the-art approaches, such as Brain Latent Progression (BrLP),…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Cheng Wan , Bahram Jafrasteh , Ehsan Adeli , Miaomiao Zhang , Qingyu Zhao

Generative modeling frameworks have emerged as an effective approach to capture high-dimensional image distributions from large datasets without requiring domain-specific knowledge, a capability essential for longitudinal disease…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Ayantika Das , Arunima Sarkar , Keerthi Ram , Mohanasankar Sivaprakasam

In this study, we proposed and evaluated a graph-based framework to assess variations in Alzheimer's disease (AD) neuropathologies, focusing on classic (cAD) and rapid (rpAD) progression forms. Histopathological images are converted into…

Image and Video Processing · Electrical Eng. & Systems 2024-07-08 Gabriel Jimenez , Leopold Hebert-Stevens , Benoit Delatour , Lev Stimmer , Daniel Racoceanu

Small-world structures are often used to describe structural connections in the brain. In this work, we compare the structural connection of cortical areas of a healthy brain and a brain affected by Alzheimer's disease with artificial…

Neurons and Cognition · Quantitative Biology 2020-04-22 José C. P. Coninck , Fabiano A. S. Ferrari , Adriane S. Reis , Kelly C. Iarosz , Antonio M. Batista , Ricardo L. Viana

Alzheimer's disease (AD) progresses from asymptomatic changes to clinical symptoms, emphasizing the importance of early detection for proper treatment. Functional magnetic resonance imaging (fMRI), particularly dynamic functional network…

Computational Engineering, Finance, and Science · Computer Science 2024-08-02 Yuxiang Wei , Anees Abrol , James Lah , Deqiang Qiu , Vince D. Calhoun

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, structural brain changes, and genetic predispositions. This study leverages machine-learning and statistical techniques to investigate…

Applications · Statistics 2025-10-29 Riddhik Basu , Arkaprava Roy

Small sample sizes in neuroimaging in general, and in structural connectome (SC) studies in particular limit the development of reliable biomarkers for neurological and psychiatric disorders - such as Alzheimer's disease and schizophrenia -…

Unveiling pathological brain changes associated with Alzheimer's disease (AD) is a challenging task especially that people do not show symptoms of dementia until it is late. Over the past years, neuroimaging techniques paved the way for…

Quantitative Methods · Quantitative Biology 2018-08-07 Mayssa Soussia , Islem Rekik

Complex multilayer network datasets have become ubiquitous in various applications, including neuroscience, social sciences, economics, and genetics. Notable examples include brain connectivity networks collected across multiple patients or…

Social and Information Networks · Computer Science 2026-03-06 Alexander Kagan , Peter W. MacDonald , Elizaveta Levina , Ji Zhu

A central idea in understanding brains and building artificial intelligence is that structure determines function. Yet, how the brain's complex structure arises from a limited set of genetic instructions remains a key question. The ultra…

Neurons and Cognition · Quantitative Biology 2026-01-28 Xingyu Liu , Yubin Li , Guozhang Chen

The number of samples in structural brain MRI studies is often too small to properly train deep learning models. Generative models show promise in addressing this issue by effectively learning the data distribution and generating…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Wei Peng , Tian Xia , Fabio De Sousa Ribeiro , Tomas Bosschieter , Ehsan Adeli , Qingyu Zhao , Ben Glocker , Kilian M. Pohl