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In this study we propose a deformation-based framework to jointly model the influence of aging and Alzheimer's disease (AD) on the brain morphological evolution. Our approach combines a spatio-temporal description of both processes into a…

Neurons and Cognition · Quantitative Biology 2019-05-27 Raphaël Sivera , Hervé Delingette , Marco Lorenzi , Xavier Pennec , Nicholas Ayache

Characterizing the subtle changes of functional brain networks associated with the pathological cascade of Alzheimer's disease (AD) is important for early diagnosis and prediction of disease progression prior to clinical symptoms. We…

Neurons and Cognition · Quantitative Biology 2020-11-12 Mengjia Xu , David Lopez Sanz , Pilar Garces , Fernando Maestu , Quanzheng Li , Dimitrios Pantazis

Structures of brain arterial networks (BANs) - that are complex arrangements of individual arteries, their branching patterns, and inter-connectivities - play an important role in characterizing and understanding brain physiology. One would…

Computer Vision and Pattern Recognition · Computer Science 2022-03-23 Xiaoyang Guo , Aditi Basu Bal , Tom Needham , Anuj Srivastava

Brain imaging has allowed neuroscientists to analyze brain morphology in genetic and neurodevelopmental disorders, such as Down syndrome, pinpointing regions of interest to unravel the neuroanatomical underpinnings of cognitive impairment…

Computer Vision and Pattern Recognition · Computer Science 2024-09-23 Jordi Malé , Juan Fortea , Mateus Rozalem Aranha , Yann Heuzé , Neus Martínez-Abadías , Xavier Sevillano

The human brain displays rich communication dynamics that are thought to be particularly well-reflected in its marked community structure. Yet, the precise relationship between community structure in structural brain networks and the…

Neurons and Cognition · Quantitative Biology 2020-12-23 Shubhankar P. Patankar , Jason Z. Kim , Fabio Pasqualetti , Danielle S. Bassett

Graph theoretical methods have proven valuable for investigating alterations in both anatomical and functional brain connectivity networks during Alzheimer's disease (AD). Recent studies suggest that representing brain networks in a…

Neurons and Cognition · Quantitative Biology 2025-04-04 Alice Longhena , Martin Guillemaud , Fabrizio De Vico Fallani , Raffaella Lara Migliaccio , Mario Chavez

Recent advances in neuroimaging along with algorithmic innovations in statistical learning from network data offer a unique pathway to integrate brain structure and function, and thus facilitate revealing some of the brain's organizing…

Signal Processing · Electrical Eng. & Systems 2021-12-21 Yang Li , Gonzalo Mateos , Zhengwu Zhang

The structure and variability of the brain's connections can be investigated via prediction of non-imaging phenotypes using neural networks. However, known neuroanatomical relationships between input features are generally ignored in…

Image and Video Processing · Electrical Eng. & Systems 2023-01-06 Yuqian Chen , Fan Zhang , Leo R. Zekelman , Tengfei Xue , Chaoyi Zhang , Yang Song , Nikos Makris , Yogesh Rathi , Weidong Cai , Lauren J. O'Donnell

Alzheimer's Disease (AD) is an irreversible neurodegenerative disorder affecting millions of individuals today. The prognosis of the disease solely depends on treating symptoms as they arise and proper caregiving, as there are no current…

Image and Video Processing · Electrical Eng. & Systems 2024-12-17 Prayas Sanyal , Srinjay Mukherjee , Arkapravo Das , Anindya Sen

Alzheimer's disease (AD) and Lewy body dementia (LBD) present overlapping clinical features yet require distinct diagnostic strategies. While neuroimaging-based brain network analysis is promising, atlas-based representations may obscure…

Neurons and Cognition · Quantitative Biology 2026-02-25 Minheng Chen , Tong Chen , Chao Cao , Jing Zhang , Tianming Liu , Li Su , Dajiang Zhu

Brain connectivity networks, derived from magnetic resonance imaging (MRI), non-invasively quantify the relationship in function, structure, and morphology between two brain regions of interest (ROIs) and give insights into gender-related…

Image and Video Processing · Electrical Eng. & Systems 2020-09-25 Ahmed Nebli , Islem Rekik

Cognition is supported by neurophysiological processes that occur both in local anatomical neighborhoods and in distributed large-scale circuits. Recent evidence from network control theory suggests that white matter pathways linking…

Neurons and Cognition · Quantitative Biology 2016-06-30 John D. Medaglia , Shi Gu , Fabio Pasqualetti , Rebecca L. Ashare , Caryn Lerman , Joseph Kable , Danielle S. Bassett

A major challenge in neuroimaging is understanding the mapping of neurophysiological dynamics onto cognitive functions. Traditionally, these maps have been constructed by examining changes in the activity magnitude of regions related to…

This article introduces a predictor-dependent joint modeling framework for network data obtained from multiple subjects over a shared set of nodes with spatial co-ordinates and spatially correlated nodal attributes. The framework is highly…

Network data are increasingly collected along with other variables of interest. Our motivation is drawn from neurophysiology studies measuring brain connectivity networks for a sample of individuals along with their membership to a low or…

Methodology · Statistics 2018-09-11 Daniele Durante , David B. Dunson

In this work, we introduce a technique of deriving symmetric connectivity matrices from regional histograms of grey-matter volume estimated from T1-weighted MRIs. We then validated the technique by inputting the connectivity matrices into a…

Quantitative Methods · Quantitative Biology 2020-05-28 Matthew Leming , Simon Baron-Cohen , John Suckling

To improve the statistical power for imaging biomarker detection, we propose a latent variable-based statistical network analysis (LatentSNA) that combines brain functional connectivity with internalizing psychopathology, implementing…

Methodology · Statistics 2023-09-21 Selena Wang , Yunhe Liu , Wanwan Xu , Xinyuan Tian , Yize Zhao

Some evidence suggests that people with autism spectrum disorder exhibit patterns of brain functional dysconnectivity relative to their typically developing peers, but specific findings have yet to be replicated. To facilitate this…

Methodology · Statistics 2025-03-03 Hyoshin Kim , Sujit K. Ghosh , Emily C. Hector

With distinct advantages in power over behavioral phenotypes, brain imaging traits have become emerging endophenotypes to dissect molecular contributions to behaviors and neuropsychiatric illnesses. Among different imaging features, brain…

Applications · Statistics 2022-12-05 Yize Zhao , Changgee Chang , Jingwen Zhang , Zhengwu Zhang

We tackle classification based on brain connectivity derived from diffusion magnetic resonance images. We propose a machine-learning model inspired by graph convolutional networks (GCNs), which takes a brain connectivity input graph and…

Neurons and Cognition · Quantitative Biology 2023-09-21 Anees Kazi , Jocelyn Mora , Bruce Fischl , Adrian V. Dalca , Iman Aganj
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